Neurogenetics in neurology: from molecular neuroscience to precision medicine

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Matthew James Farrer

University of Florida

McGill University

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Advances in neurogenetics, in linkage, association and massively parallel sequencing approaches have begun to define a precise molecular etiology of neurologic disorders. The findings have refined diagnoses, often challenging nosology, and have proven foundational for molecular neuroscience and modelling. Many discoveries have paved the way for novel therapeutic development and ‘precision medicine’ (where genotype informs treatment). This Research Topic will illustrate progress over the past 20 years in many specialty areas of neurology, from neurometabolic disorders in neonates to age-associated neurodegeneration. The challenges are profound, and much of the work is ongoing, but each article will serve to provide an authoritative introspective critique of prior success and failure, postulating the underlying reasons. Each article must be balanced and well referenced and should also reflect the opinion of its author(s) so as to provide their insight/strategy to help direct their field. Articles may be focused on a single gene, subsequent research and therapeutic development, or they may take a lateral perspective. The overall objective of the Research Topic, and each article within it, is to inform future molecular therapeutic efforts aimed at mitigating neurologic disease.

Advances in neurogenetics, in linkage, association and massively parallel sequencing approaches have begun to define a precise molecular etiology of neurologic disorders. The findings have refined diagnoses, often challenging nosology, and have proven foundational for molecular neuroscience and modelling. Many discoveries have paved the way for novel therapeutic development and ‘precision medicine’ (where genotype informs treatment). This Research Topic will illustrate progress over the past 20 years in many specialty areas of neurology, from neurometabolic disorders in neonates to age-associated neurodegeneration. The challenges are profound, and much of the work is ongoing, but each article will serve to provide an authoritative introspective critique of prior success and failure, postulating the underlying reasons. Each article must be balanced and well referenced and should also reflect the opinion of its author(s) so as to provide their insight/strategy to help direct their field. Articles may be focused on a single gene, subsequent research and therapeutic development, or they may take a lateral perspective. The overall objective of the Research Topic, and each article within it, is to inform future molecular therapeutic efforts aimed at mitigating neurologic disease.

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Editors

Matthew James Farrer

University of Florida

McGill University

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Frontiers in Neurology

Movement Disorders, Neurogenetics, Pediatric Neurology, Stroke, Dementia and Neurodegenerative Diseases

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Frontiers in Pediatrics

Pediatric Neurology

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