About this Research Topic
The signals that determine which DSB repair pathway is used at a given time in a given DNA lesion are still not completely understood. Cellular features, such as cell cycle phase, or local chromatin cues that we are only now starting to understand, play important roles during the choice of the appropriate DNA repair mechanism. In this collection of articles, we aim to expose our current understanding of these local signals that impact the way a DSB is repaired. These include chromatin environment and epigenetic marks, local levels of gene expression, the interference of DNA: RNA hybrids, the presence of atypical DNA conformations close to the breaks or the chemical and physical signatures of the DNA ends themselves. In this Research Topic, we will review how these local cues affect the recognition, signalling and repair of chromosome breaks, how they impact genomic stability, cell viability or organismal fitness and their relationship with human pathologies such as inherited rare diseases, neurodegeneration and cancer.
Keywords: DNA repair, Recombination, NHEJ, Chromatin, Epigenetic marks
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.