Research Topic

Molecular Mechanisms of Thiol-Based Redox Homeostasis and Signaling in the Brain

About this Research Topic

It is becoming increasingly clear that thiols play a central role in maintenance of redox homeostasis in living systems. Thiols undergo a myriad of redox reactions which contribute to a rich array of signaling molecules. Thus, cells are endowed with a multitude of sulfur containing molecules such as cysteine, ...

It is becoming increasingly clear that thiols play a central role in maintenance of redox homeostasis in living systems. Thiols undergo a myriad of redox reactions which contribute to a rich array of signaling molecules. Thus, cells are endowed with a multitude of sulfur containing molecules such as cysteine, homocysteine, lanthionine and taurine, peptides such as glutathione and gaseous signaling molecules such as hydrogen sulfide. Cysteine residues on proteins undergo the maximum number of posttranslational modifications, which include but is not limited to nitrosylation, persulfidation, sumoylation and palmitoylation. These modifications play vital roles in cellular physiology and fine tune responses to stress stimuli as well as normal cellular processes. Redox signaling is especially important in the brain, which is metabolically highly active. Disruption of redox signaling is a hallmark of several neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis and Ataxias. Emerging evidence suggests that redox imbalances contribute to disease progression and pathophysiology of these diseases. Redox signaling in the brain has been relatively less studies as compared to that in peripheral tissues.

In this Research Topic, we bring together, a collection of articles that highlight the signal transduction cascades operating in the brain, their derangement in neurodegeneration and methods to quantify and detect these processes as well as points of therapeutic intervention.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 September 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 September 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..