About this Research Topic
Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis. This bacterium, together with Mycobacterium tuberculosis, the etiological agent of human TB, belongs to the M. tuberculosis complex and both are responsible for a similar pulmonary disease. M. bovis can be transmitted to humans through the consumption of unpasteurized milk and derivatives. Furthermore, this pathogen is a potential risk to workers in close contact with infected animals, especially in slaughterhouses. The impact of bTB in the meat and dairy industries results in serious economical losses. As a zoonotic disease and a human health hazard, bTB is considered a One Health issue.
This Research Topic is focused towards the scientific community working on bTB. It will address recent and original studies about new candidate vaccines, diagnostic and immune response in relation to this zoonotic disease. Results obtained in the natural host, cattle, will be appreciated, although studies conducted in other animal models like mice or guinea pigs will also be considered. Immunopathology and studies of natural infected animals will be also in consideration to gain knowledge on the evolution of the disease and factors involving natural resistance and behavior of the different M. bovis isolates. The main goal of the present issue is to gather recent information and new approaches in this research field. We want to encourage our colleagues to present their new results in this special dedicated and exclusive issue on bTB around themes including, but not limited to, the following:
• Original research articles about advances in bTB diagnostic and biomarkers.
• New candidate vaccines against bTB tested in field trials or animal models.
• Immune response and cellular biology in M. bovis infection, preferentially studies in the natural host.
• Immunopathology and histological findings of bTB associated lesions in infected cattle or animal models.
• Review articles of the mentioned topics will be also considered.
Keywords: bovine, tuberculosis, bTB, mycobacterium
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.