Research Topic

Aurora kinases: classical mitotic roles, non-canonical functions and translational views

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Aurora kinases are key mitotic regulators that have been also associated with tumor development and progression. The interest on this highly conserved family of protein kinases has grown exponentially since they were discovered in the 90’s. Despite the big number of research groups involved in this field and ...

Aurora kinases are key mitotic regulators that have been also associated with tumor development and progression. The interest on this highly conserved family of protein kinases has grown exponentially since they were discovered in the 90’s. Despite the big number of research groups involved in this field and the amount of papers produced, new discoveries come to light frequently. As a consequence, the research in Aurora kinases has become a very dynamic area in which new perspectives are continuously opening to the scientific community. Importantly, many Aurora kinase inhibitors have been developed during the last years and are currently being tested in preclinical and clinical assays for cancer treatment.
Here we would like to create a forum in which Aurora kinase researchers can review and revisit different aspects of the Aurora research field and also make public their latest discoveries. We also want to welcome researchers to contribute their opinions and new views, paying special attention to those that can create new avenues for the investigation of Aurora kinase function through multidisciplinary approaches.
Topics will include: (i) latest advances on Aurora kinase mitotic functions; (ii) non-mitotic roles of Aurora kinases; (iii) mechanisms underlying the malignant phenotype induced by Aurora kinases; (iv) therapeutical opportunities associated with Aurora inhibition.


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