About this Research Topic
Redox reactions play an essential role in the regulation of physiological processes and maintenance of cellular homeostasis. Current concepts in redox biology also emphasize that increased oxidant production and redox dysregulation are involved in the development of inflammatory and immune-related pathologies through many different and diverse pathways. During evolution, specific strategies have been developed by mammalian cells to manage pro-oxidant conditions, maintain redox balance and utilize these agents for the regulation of biochemical pathways. Physiologic antioxidant strategies comprise of (i) agents that catalytically remove oxidants; (ii) molecules that decrease the production of reactive oxygen species; (iii) proteins that physically protect biomolecules against oxidative damage and (iv) enzymes that catalyze reduction of cofactors to preserve reduced states of important biomolecules. Application of small molecules specifically targeting enzymatic sources of reactive oxygen species, antioxidants, and pharmacological or genetic modulation of dysregulated redox signaling cascades are currently available tools to restore redox homeostasis in pathological processes. Despite recent advances in the field of redox biology, much remains unknown about the specific mechanisms by which redox pathways are regulated and their pathological role in inflammatory and immune disorders.
This Research Topic aims to provide researchers with a forum to publish original, innovative, and state-of-the art research articles in the area of redox regulation of inflammatory diseases. The overall goals of this Research Topic are (i) to summarize evidence that mechanistically links reactive oxygen species and dysregulation of redox signaling pathways to inflammatory processes and immune disorders, (ii) to provide data supporting the contribution of specific oxidant-generating enzymatic pathways, such as NADPH oxidase, to dysregulation of redox signaling processes in vitro and in vivo; (iii) to describe novel redox sensitive pathways in inflammatory and immune disorders; and (iv) to demonstrate new genetic approaches, pharmacological tools, and methodologies to study redox signaling.
We welcome the submission of Original Research, Methods, Review, Mini-Review and Perspective articles that fit within the framework of this Research Topic.