Nanotechnology has revolutionized various fields, particularly in healthcare, with its potential for precise diagnosis and treatment. In diagnostics, nanotechnology offers unparalleled sensitivity and specificity through nanoparticle-based assays, biomarker detection, and point-of-care diagnostics. These advancements enable early disease detection and personalized medicine, ultimately improving patient outcomes. Integrating nanotechnology with imaging techniques enhances visualization of molecular events, aiding in disease diagnosis and monitoring. Additionally, combining diagnostics and therapy through theranostics shows promise in targeted drug delivery and responsive treatment approaches. This Research Topic highlights the presentations from the 2023 and 2024 NanoBioTech Conference on the advancements in Nano-based Diagnostics for Health and Disease made by researchers in both industry and academia, in conjunction with the materials and computational research that make these technologies possible.While the field of Nano-based Diagnostics for Health and Disease continues to evolve, challenges such as clinical translation and regulatory considerations persist. Nonetheless, the impact of nano-based diagnostics is already felt in society, with improved disease management, reduced healthcare costs, and enhanced quality of life for individuals worldwide. Exploring further advancements in nanoparticle engineering, miniaturized sensor platforms, and regulatory frameworks will propel this research toward even greater societal benefits.This Research Topic seeks to draw attention to nanobiotechnology research at any level of technology readiness that has the goal of developing diagnostic approaches for monitoring health and disease at home or in the clinical laboratory. The research can range from technology concept development to proof of concept validation all the way to prototype presentation and validation. Innovations in education to improve capability in nano-diagnostic research and diversification of researchers in nano-theranostics are also of interest to this Research Topic. We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:• Nanoparticle-based assays: Surface functionalization, Signal amplification, Multiplexed detection, Microfluidic integration, Quantum dots & gold nanoparticles.• Biomarker detection: Biomarker identification & validation, Sensing mechanisms, Signal pathways, Miniaturized sensors, Clinical validation challenges.• Point-of-care diagnostics: Handheld device design, Sample preparation methods, Nano-microfluidic integration, User-friendly interfaces, Regulatory considerations.• Imaging techniques: Molecular contrast agents, Nanotech-enabled high-resolution imaging, Functionalized nanoparticle imaging, In vivo modalities, Image analysis for diagnosis.• Theranostics: Imaging & therapy nanomaterials, Targeted drug delivery, Controlled release platforms, In vitro & in vivo evaluations, Clinical trial challenges.• Nano-Theranostics education: Innovative pedagogies in multi-dimensional research training, Interdisciplinary education programs in preparation for graduate research, Multidisciplinary approaches
Nanotechnology has revolutionized various fields, particularly in healthcare, with its potential for precise diagnosis and treatment. In diagnostics, nanotechnology offers unparalleled sensitivity and specificity through nanoparticle-based assays, biomarker detection, and point-of-care diagnostics. These advancements enable early disease detection and personalized medicine, ultimately improving patient outcomes. Integrating nanotechnology with imaging techniques enhances visualization of molecular events, aiding in disease diagnosis and monitoring. Additionally, combining diagnostics and therapy through theranostics shows promise in targeted drug delivery and responsive treatment approaches. This Research Topic highlights the presentations from the 2023 and 2024 NanoBioTech Conference on the advancements in Nano-based Diagnostics for Health and Disease made by researchers in both industry and academia, in conjunction with the materials and computational research that make these technologies possible.While the field of Nano-based Diagnostics for Health and Disease continues to evolve, challenges such as clinical translation and regulatory considerations persist. Nonetheless, the impact of nano-based diagnostics is already felt in society, with improved disease management, reduced healthcare costs, and enhanced quality of life for individuals worldwide. Exploring further advancements in nanoparticle engineering, miniaturized sensor platforms, and regulatory frameworks will propel this research toward even greater societal benefits.This Research Topic seeks to draw attention to nanobiotechnology research at any level of technology readiness that has the goal of developing diagnostic approaches for monitoring health and disease at home or in the clinical laboratory. The research can range from technology concept development to proof of concept validation all the way to prototype presentation and validation. Innovations in education to improve capability in nano-diagnostic research and diversification of researchers in nano-theranostics are also of interest to this Research Topic. We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:• Nanoparticle-based assays: Surface functionalization, Signal amplification, Multiplexed detection, Microfluidic integration, Quantum dots & gold nanoparticles.• Biomarker detection: Biomarker identification & validation, Sensing mechanisms, Signal pathways, Miniaturized sensors, Clinical validation challenges.• Point-of-care diagnostics: Handheld device design, Sample preparation methods, Nano-microfluidic integration, User-friendly interfaces, Regulatory considerations.• Imaging techniques: Molecular contrast agents, Nanotech-enabled high-resolution imaging, Functionalized nanoparticle imaging, In vivo modalities, Image analysis for diagnosis.• Theranostics: Imaging & therapy nanomaterials, Targeted drug delivery, Controlled release platforms, In vitro & in vivo evaluations, Clinical trial challenges.• Nano-Theranostics education: Innovative pedagogies in multi-dimensional research training, Interdisciplinary education programs in preparation for graduate research, Multidisciplinary approaches