Nanomedicine and nanotherapy have revolutionized cancer treatment, offering unprecedented precision and effectiveness compared to conventional therapies. Leveraging the unique properties of nanoparticles, these advanced modalities aim to improve drug delivery, enhance therapeutic efficacy, and minimize side effects, marking significant strides in oncological care.
Nanomedicine employs nanoparticles as carriers for anticancer drugs, allowing for targeted delivery to tumor sites. Due to their small size and high surface area-to-volume ratio, nanoparticles can be engineered to evade the immune system and accumulate preferentially in tumors via the enhanced permeability and retention (EPR) effect. This targeting capability reduces systemic toxicity and enhances drug concentration at the tumor site, improving therapeutic outcomes. Various types of nanoparticles, including liposomes, dendrimers, polymeric nanoparticles, and inorganic nanoparticles such as gold and silica, have been developed for cancer therapy. Each type offers unique advantages in terms of drug loading capacity, release kinetics, and biocompatibility. For instance, liposomes can encapsulate both hydrophilic and hydrophobic drugs, providing a versatile platform for cancer treatment.
Nanotherapy encompasses not only drug delivery but also innovative therapeutic approaches such as photothermal therapy (PTT) and photodynamic therapy (PDT). In PTT, nanoparticles like gold nanorods absorb near-infrared light and convert it into heat, selectively destroying cancer cells. PDT involves photosensitizer-loaded nanoparticles that produce reactive oxygen species upon light activation, inducing cell death in targeted cancer cells.
Nanomedicine and Nanotherapy represent cutting-edge research in treatment. Therefore, this Research Topic will focus on recent advancements in nanotechnology for cancer treatment. We welcome Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, Data notes, and technical notes.
• Investigating the design and efficacy of multifunctional nanoparticles capable of delivering a combination of chemotherapy.
• Developing nanoparticles functionalized with targeting ligands (e.g., antibodies, peptides) for specific delivery to cancer cells.
• Exploring the use of nanoparticles for the delivery of genetic material (e.g., siRNA, CRISPR-Cas9) to silence oncogenes or repair tumor suppressor genes in cancer cells.
• Developing nanoparticle formulations that can bypass mechanisms of drug resistance in cancer cells.
Nanomedicine and nanotherapy have revolutionized cancer treatment, offering unprecedented precision and effectiveness compared to conventional therapies. Leveraging the unique properties of nanoparticles, these advanced modalities aim to improve drug delivery, enhance therapeutic efficacy, and minimize side effects, marking significant strides in oncological care.
Nanomedicine employs nanoparticles as carriers for anticancer drugs, allowing for targeted delivery to tumor sites. Due to their small size and high surface area-to-volume ratio, nanoparticles can be engineered to evade the immune system and accumulate preferentially in tumors via the enhanced permeability and retention (EPR) effect. This targeting capability reduces systemic toxicity and enhances drug concentration at the tumor site, improving therapeutic outcomes. Various types of nanoparticles, including liposomes, dendrimers, polymeric nanoparticles, and inorganic nanoparticles such as gold and silica, have been developed for cancer therapy. Each type offers unique advantages in terms of drug loading capacity, release kinetics, and biocompatibility. For instance, liposomes can encapsulate both hydrophilic and hydrophobic drugs, providing a versatile platform for cancer treatment.
Nanotherapy encompasses not only drug delivery but also innovative therapeutic approaches such as photothermal therapy (PTT) and photodynamic therapy (PDT). In PTT, nanoparticles like gold nanorods absorb near-infrared light and convert it into heat, selectively destroying cancer cells. PDT involves photosensitizer-loaded nanoparticles that produce reactive oxygen species upon light activation, inducing cell death in targeted cancer cells.
Nanomedicine and Nanotherapy represent cutting-edge research in treatment. Therefore, this Research Topic will focus on recent advancements in nanotechnology for cancer treatment. We welcome Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, Data notes, and technical notes.
• Investigating the design and efficacy of multifunctional nanoparticles capable of delivering a combination of chemotherapy.
• Developing nanoparticles functionalized with targeting ligands (e.g., antibodies, peptides) for specific delivery to cancer cells.
• Exploring the use of nanoparticles for the delivery of genetic material (e.g., siRNA, CRISPR-Cas9) to silence oncogenes or repair tumor suppressor genes in cancer cells.
• Developing nanoparticle formulations that can bypass mechanisms of drug resistance in cancer cells.