About this Research Topic
Cancer biology has expanded from the study of cancer cells in isolation to more broadly studying cancer cells in their tumor micro and macroenvironment. We are learning how cancer thrives in the host ecosystem and for example now understand that the extracellular matrix is reprogrammed by cancer cells to allow invasion and metastasis. Cancer cells release cytokines and growth factors that alter cancer-associated stromal cells which in turn transform the extracellular matrix. More recent work has focused on intratumoral metabolic interactions and how different tumor cell populations obtain high energy catabolites from other cells in tumors to promote their growth. We are also learning that there are redox differences in the different cell populations in tumors and that there is intratumoral compartmentalization of autophagy and senescence.
Articles will include original research articles and reviews that focus on research that has the potential for clinical applications targeting cancer micro and macroenvironments. Articles should discuss potential applications of the knowledge in cancer ecosystems to allow for precision medicine in oncology based on the interactions between different molecules, organelles, cells and orgains withn the context of patients living with cancer. The focus of articles will be to evaluate molecular, cellular, tissue, organ and organismal responses to perturbations in the ecosystem. Studying how the different cancer compartments support growth from a metabolic, redox and cell signaling perspective is novel and a focused forum is needed.
The aim of the Research Topics is to provide novel mechanistic insights into interactions in the tumor and at a distance. Heterogeneous topics in all areas of cancer pathophysiology spanning from in vitro experimental work to clinical trials would be covered. Important topics to include are:
• Intratumoral Metabolic Interactions
• Mitochondria and Cancer Ecosystems
• Multicompartment redox modulation in tumors
• Intratumoral compartmentalization of autophagy and senescence
• Matrix-cancer interactions
• Immune-cancer cell interactions
• Soluble elements that regulate cancer ecosystems
• Genetic regulators of cancer ecosystems
• Epigenetic regulators of cancer ecosystems
• Vasculature and cancer ecosystems
• Microbiota and cancer ecosystems
Keywords: Metabolism, microenvironment, redox-state, glycolysis, mitochondria
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.