5-Hydroxymethyl-2-Furfural Oxidation Over Au/CexZr1-xO2 Catalysts

Introduction

The oxidation of 5-hydroxymethyl-2-furfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is widely recognized as a potential process to replace petroleum-derived chemical, terephthalic acid, with a biorefinery-derived one (Zhang and Deng, 2015). Due to its chemical similarity, the polymerization of FDCA (concretely the dimethyl ester of FDCA) with ethylene glycol forms polyethylene furanoate (PEF), a plastic based polymer comparable to polyethylene terephthalate (PET) (Gandini et al., 2008). Certainly, recent studies have focused on the comparison of PEF and PET overall performances, revealing PEF's superiority in terms of physical, mechanical, and thermal properties (Burgess et al., 2014). The latter has motivated the scientific community to investigate FDCA production processes, mainly based on the efficient transformation of 5-hydroxymethyl-2-furfural (HMF). Most research focused on the catalytic screening of several systems, mainly based on noble metals, under different reaction conditions, being Ru (Nie et al., 2013; Yi et al., 2016), Pd (Siyo et al., 2014; Liu et al., 2015; Zhang et al., 2015), Pt (Siankevich et al., 2014; Ait Rass et al., 2015; Han et al., 2016), and Au (Lolli et al., 2015; Masoud et al., 2018; Megías-Sayago et al., 2018) the most reported. The HMF oxidation performances, logically, depend on the used metal, the support's chemical nature and the employed reaction conditions, with a special emphasis on the presence or absence of base (Zope et al., 2010; Pasini et al., 2011; Ardemani et al., 2015; Menegazzo et al., 2015; Du et al., 2018; Ferraz et al., 2018). Among the noble metals, gold has demonstrated to be alike to the others, more resistant to deactivation by overoxidation (Zhang and Deng, 2015) and sometimes even more active (Davis et al., 2011, 2012; Zhang and Deng, 2015).

The HMF molecule possesses two side chain functional groups, aldehyde and alcohol, and their cascade oxidation leads to the dicarboxylic acid, i.e., FDCA. The general reaction network (Scheme 1) includes 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), 2,5-diformylfuran (DFF), 5-formyl-2-furancarboxylic acid (FFCA), and final 2,5-furandicarboxylic acid (FDCA). The use of gold orientate the HMF oxidation via HMFCA pathway, DFF is never detected, being the rate-limiting step the HMFCA to FFCA oxidation (Casanova et al., 2009; Albonetti et al., 2012; Lolli et al., 2015).

SCHEME 1

Scheme 1. General reaction network for HMF oxidation.

Interesting studies concerning mechanistic aspects have been carried out by Davis' group (Zope et al., 2010; Davis et al., 2012). They proved, by means of labeling experiments, that gold/water interfaces in presence of oxygen participate in the formation of hydroxyl ions from dioxygen and water, being the formed ions included in the reaction. Both hydroxyl species and HMF adsorb on gold surface without a direct support contribution in this mechanism. On the other hand, a recent study of our group (Megías-Sayago et al., 2018) reported a key role for the support surface in the rate-limiting step, particularly of support's Brönsted acidity and its participation in the reaction mechanism. Although reported as a key factor influencing the activity, the acidity is not the only one. The active sites access, reactive adsorption, product desorption, and selectivity are influenced by support's textural, redox, and electronic properties. There is actually a lack of studies relating all support properties to HMF conversion and FDCA yield over gold-based catalysts. That is why the present work aims to give more insights on the influence of the support's properties in the HMF oxidation reaction over a series of Au/Ce_xZr_1−xO₂ catalysts.

Experimental

Materials

HAuCl₄ (Johnson Matthey), Ce(NO₃)₃·6H₂O (Sigma Aldrich), and ZrN₂O₇·xH₂O (Sigma Aldrich) were used as precursors for the preparation of catalyst series. The following products were used for the reaction: sodium hydroxide (Sigma Aldrich), 5-hydroxymethyl-2-furfural (AVA Biochem), 2,5-furandicarboxylic acid, 5-hydroxymethyl-2-furancarboxylic acid, 5-formyl-2-furancarboxylic acid, and 2,5-diformylfuran (the last three from Toronto Research Chemicals).

Catalyst Preparation

Homemade supports were prepared according to coprecipitation method (Letichevsky et al., 2005), using the appropriate precursor quantities to obtain Ce-Zr mixed systems of 25 and 50 wt% in CeO₂ (named as Ce25Zr and Ce50Zr, respectively). Zirconium precursor was dissolved in hot water and then mixed with cerium precursor under continuous stirring at pH 9, adjusted with NH₃ (Panreac). Solids were dried at 110°C during 4 h and calcined in static air at 500°C for 1 h, with a heat ramp of 10°C/min. Analogous procedure was used for pure oxides, CeO₂ and ZrO₂ (named Ce and Zr, respectively). All the solids were powdered in an agate mortar with the fraction of 100–200 mm used for gold deposition. Gold (2 wt% nominal value) was deposited on the four different supports according to the Direct Anionic Exchange (DAE) method assisted by ammonia, proposed previously by Ivanova et al. (2004). In a typical procedure, a solution of the gold precursor (around 10⁻⁴ M) was heated to 70°C, and contacted with the support for 20 min. After that, a suitable amount of NH₃ was added. The final solid was filtered, dried at 100°C overnight and calcined at 300°C for 4 h. This method was chosen for its relative reproducibility in loadings and particles size for supports with similar isoelectric point and chemical compositions.

Characterization Techniques

XRD measurements were performed at room temperature on Panalitycal X'Pert Pro diffractometer, equipped with Cu anode. All diffractograms were recorded in 5–90°2θ range, with 0.05° step size and 300 s acquisition time.

BET specific surface areas and pore diameters, calculated by the BJH method, were obtained using a Micromeritics Tristar II equipment. Prior to the analysis, the samples were outgassed at 250°C in vacuum.

TEM micrographs were performed both with a HRTEM Jeol 2010F and a TEM/STEM FEI TECNAI F20 using a high-angle annular dark field (HAADF) imaging mode at 200 kV.

Gold contents were determined by X Ray Fluorescence (XRF) using Panalitycal AXIOS spectrometer with Rh tube of radiation.

Temperature programmed reduction experiments (TPR-H₂) were carried out over ~50 mg of sample charged in a conventional U-shaped reactor under heating at constant rate of 10°C/min till 900°C under 50 mL/min certified 5% H₂ in Ar gas mixture. H₂ consumption was followed by TCD detector and quantified by using CuO (99.999%) standard.

For the Oxygen Storage Complete Capacity (OSCC) 100 mg of catalyst were loaded into the same U-shaped quartz reactor. Every sample was pretreated in 50 mL/min He flow at 300°C for 2 h and after cooled down to the desired temperature. For each temperature, 10 O₂ pulses of 1 mL were injected every 2 min. After that, the sample was submitted to 10 equivalent CO pulses. The OSCC is obtained from the total CO₂ produced in all CO pulses. The sample was then degassed during 10 min in a He flow and subjected to a new series of oxidizing pulses (ten O₂ pulses) and subsequently to six alternating pulses (CO–O₂-CO–O₂-CO–O₂). The OSC is determined by the average amount of CO₂ per pulse formed after the first CO pulse of the alternated ones. This method is based on that proposed by Kacimi et al. (1993) and Royer and Duprez (2011). The gas composition at the exit of the reactor was analyzed by a mass spectrometer PFEIFFER Vacuum PrismaPlus controlled by Quadera® software.

Catalytic Tests

The oxidation of HMF was performed in an autoclave reactor of 100 mL of capacity, provided with a mechanical stirrer (0–600 rpm) and measurement tools for temperature and pressure. The reactor was charged with an aqueous solution of HMF (~25 mL), the necessary amount of NaOH and the catalyst in a HMF:Au:NaOH of 1:0.01:2. Before the test, the reactor was purged two times with pure O₂ (10 bar) and finally pressurized to 10 bar. Temperature was increased to 70°C and the reaction mixture was stirred at ~400 rpm for 4 h. The reaction starts (t = 0) when the temperature reached 70°C (about 10 min). After 4 h, the reactor was cooled down to room temperature in an ice bath and the reaction mixture centrifuged and filtered. A sample was taken and diluted before analysis with an Agilent Infinity 1260 liquid chromatograph equipped with an Aminex HPX-87H 300 mm × 7.8 mm column using 0.005 M H₂SO₄ as eluent. Conversion, selectivity and yield were calculated from peak areas, after calibration using reference commercial samples, according to the following equations:

$\begin{array}{ll}Conversion(\%)=\frac{{\left[HMF\right]}_I-{\left[HMF\right]}_F}{{\left[HMF\right]}_I}x100& (1)\end{array}$

$\begin{array}{ll}FDCASelectivity(\%)=\frac{FDCAmoles}{{HMFmoles}_I-{HMFmoles}_F}x100& (2)\end{array}$

$\begin{array}{ll}FDCAYield(\%)=\frac{Conversion}{100}xSelectivity& (3)\end{array}$

Results and Discussion

Catalysts Characterization

Table 1 summarizes the chemical composition of the samples estimated by X-Ray Fluorescence (XRF), the gold particles sizes estimated by TEM and the calculated gold dispersions. The composition of the mixed oxides results to be very close to all targeted values, being 44.7 and 24.2 wt% CeO₂ for Ce50Zr and Ce25Zr samples, respectively. Regarding the gold loadings, out of AuCe sample that shows unexpectedly high amount, all other samples demonstrate good approximation to the targeted values. Considering that the gold deposition was carried out with the same procedure for all the samples (same precursor to support ratio), the doubled Au loading for the AuCe sample indicates analysis problem or a probable matrix effect. The same was observed for a series of Au/CeZr catalysts prepared over commercial supports with similar composition, reported elsewhere (Megías-Sayago et al., 2018).

TABLE 1

Table 1. Chemical compositions and dispersion of the selected solids.

CeO₂ sample presents a set of intense diffractions (Figure 1) corresponding to the cubic fluorite structure (ICSD #00-034-0394). For the mixed oxides, the zirconia introduction induces two evident effects. Firstly, the formation of homogeneous solid solution, predicted based on the diffraction pattern shift: Ce (111) shifts from 28.7° 2Θ to 29.3 and 29.8 for Ce50Zr and Ce25Zr samples, respectively. All binary systems present typical diffraction patterns of Ce_xZr_1−xO₂ solid solutions (Thammachart et al., 2001; Gutiérrez-ortiz et al., 2004) with absence of pure CeO₂ and ZrO₂ segregated phases. After 50% zirconia addition, the diffractions of CeO₂ fluorite structure move to higher angles, because of ceria lattice shrinkage, caused by the substitution of Ce⁴⁺ (0.098 nm ionic radii) with smaller Zr⁴⁺ cations (0.084 nm) (Gutiérrez-ortiz et al., 2004). This effect confirms the formation of a solid solution. The introduction of 75% zirconia, however, induces even higher diffraction shifts attributed to the zirconia lattice expansion due, in this case, to the replacement of Zr⁴⁺ cations with bigger Ce⁴⁺ cations. Actually and according to the literature (Gutiérrez-ortiz et al., 2004) Ce50Zr sample has a cubic structure (ICSD #00-028-0271) whereas Ce25Zr sample presents tetragonal one (ICSD #01-080-0785). Pure ZrO₂ solid shows the presence of both, cubic (ICSD #00-003-0640) and monoclinic (predominant, ICSD #00-007-0343) structures. Furthermore, the second effect induced by Zr introduction concerns particles size diminution, evidenced by the diffractions broadening in zirconia containing samples. Reina et al. (2013) observed similar effect with the introduction of defects for the cerium iron mixed oxides. This effect could be ascribed to the different nucleation rate between ZrO₂ and CeO₂-rich phases. Regarding gold catalysts, no diffraction attributed to gold (vertical dashed lines) appears suggesting small gold particles size.

FIGURE 1

Figure 1. X-ray diffraction patterns of Ce_xZr_1−x O₂ supports and its corresponding gold catalysts. Main gold diffractions are marked as .

Indeed, a small average gold particle size is estimated using High-resolution transmission electron microscopy (HR-TEM) combined with high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM). Due to the similar atomic weight of gold and cerium, their individual identification often becomes a difficult task. For this reason, both techniques were combined to get the best possible contrast. Representative micrographs and particle size distributions are presented in Figure 2.

FIGURE 2

Figure 2. TEM/STEM images and particle size distributions of prepared samples.

The mean gold particle size ranges 2.1–3.7 nm (Table 1) with a typical Gaussian like distribution. On pure CeO₂ and ZrO₂ the supported gold particles present higher average size and larger distribution, while for the mixed oxides the opposite is observed. The presence of higher Zr content seems to promote gold average particle size decrease. A plausible explication of this fact is the increase of the defect population in the mixed samples and facilitated gold nucleation over the defects sites (Hernández et al., 2010; Menegazzo et al., 2015).

Table 2 compares the specific surface area, average pore size and pore volume of Au-supported samples.

TABLE 2

Table 2. Textural properties of the studied Au catalysts.

All prepared catalysts are mesoporous solids with areas ranging from 49 to 82 m²/g, being that of pure oxides a half of the area of the mixed oxides. The solids present pore sizes around 3 nm exception made by the AuCe sample with considerately superior size (9.9 nm). The differences are also noticeable regarding the pore volume distributions, highest the average pore size highest the corresponding pore volume. We can suppose that the higher surface area for low pore size and volume for the mixed oxides corresponds to the interparticular surface, and lower the particle size (evidenced by XRD) higher the area and lower the pore size.

The catalyst's redox properties were investigated by means of temperature-programmed reduction (TPR). H₂ consumption profiles as a function of the temperature for the prepared series are presented in Figure 3. Bare ceria sample shows only one zone of reduction centered at 749°C, assigned to the reduction of surface ceria. A typical ceria samples reduction profile is characterized by two zones, surface ceria at lower temperatures and bulk ceria at higher temperatures (Gutiérrez-ortiz et al., 2004). The appearance of only one reduction zone suggests a probable bulk ceria reduction at higher temperatures (>900°C) that cannot be registered by our equipment which is consistent with some literature reports (Kaspar et al., 1999).

FIGURE 3

Figure 3. TPR-H₂ profiles of the supports (dashed lines) and their corresponding gold catalysts (full lines).

In contrast, the TPR profiles of the mixed oxides are much complex. The introduction of ZrO₂ into ceria and vice versa leads to lattice deformation, as revealed by XRD, and as a consequence, the reduction process is not limited to the surface but also involves more easily the bulk (Gutiérrez-ortiz et al., 2004). The oxide reduction (understood as loss of oxygen atoms) is strongly influenced by the oxygen mobility, utterly boosted by the presence of zirconia. Therefore, the mixed oxides reduction zones shift to lower temperatures and the reduction percentage increases. Now, it is possible to distinguish three reduction zones, attributed to oxygen atoms from different layers stuck between surface and bulk. As for ZrO₂ profile no clear reduction process is detected in agreement with the literature (Kaspar et al., 1999), although some hydrogen consumption is registered, most probably caused by hydrogen adsorption/desorption processes (Kondo et al., 1990).

When gold is introduced to the systems the reduction process is apparently more complete (higher area of the zones) and shifts to lower temperature. Presumably the hydrogen mobility is facilitated by the metal and the reduction rate rises significantly in the presence of gold (Jacobs et al., 2004). In a similar manner, the low temperature reduction zone is assigned to the noble metal promoted ceria surface reduction and the high temperature reduction process to the ceria bulk reduction. The AuCe25Zr sample shows only one reduction event centered at 163°C. It appears that the redox behavior of the mixed oxides depends on zirconia content, higher the content narrower the reduction zone at lower temperatures.

The reducibility percentages (RP) are calculated according to the following equation:

$\begin{array}{ll}RP=\frac{E_{HC}}{T_{HC}}x100& (4)\end{array}$

The RP relates the experimentally measured H₂ consumption (E_HC) to the total theoretical H₂ consumption (T_HC). The T_HC depends on the oxidation state and the number of considered reducible species. For all samples, Ce⁴⁺ species are considered reducible to Ce³⁺ species (Equation 5), whereas the Zr⁴⁺ remain irreducible under H₂ flow. As for gold, due to the auto-reduction capability of gold species during the calcination process, gold is presumably metallic, and therefore non-reducible species. The results are presented in Figure 4.

$\begin{array}{ll}2Ce{O}_2+H_2\to C{e}_2{O}_3+H_{2}O.& (5)\end{array}$

The samples of pure ceria show 50% of total reduction degree in the temperature range considered in this study. However, the mixed oxide samples present higher RP due most probably to the higher oxygen mobility. The RP decreases as following:

$\begin{array}{l}\text{AuCe}50\text{Zr}>\text{AuCe}25\text{Zr}>\text{AuCe}>\text{AuZr}\end{array}$

FIGURE 4

Figure 4. Reducibility percentage (RP) of the prepared solids.

Catalytic Tests

Before testing the catalysts, the blank tests of the supports resulted in the formation only of by-products, due to HMF degradation in the presence of NaOH. The supports were not able to convert catalytically HMF to the desired product. On the contrary, the presence of gold promoted the HMF conversion and its selective oxidation to 2,5-furandicarboxylic acid (FDCA) and 5-hydroxymethyl-2-furancaboxylic acid (HMFCA). The latter is the first reaction intermediate as shown in Scheme 1, which converts lately to 5-formylfuran-2-carboxylic acid (FFCA) and finally to FDCA. FFCA is detected only in negligible amounts due to its rapid conversion to the final product. In fact, the rate-limiting step of the reaction is the alcohol group oxidation (Siyo et al., 2014; Albonetti et al., 2015). This is the preferred pathway for HMF oxidation in presence of NaOH, diformylfuran (DFF) is never formed (Lolli et al., 2015). All catalysts showed nearly 100% of HMF conversion (Figure 5), AuZr and AuCe exhibiting higher FDCA yield than that of gold supported over mixed oxides.

FIGURE 5

Figure 5. Catalytic activity of the prepared samples. Reaction conditions: 4h, 70°C, 10 bar O₂, HMF:Au:NaOH 1:0.01:2, Legend: HMF conversion (■), HMFCA yield ($\text{■}$),FFCA yield ($\text{■}$), FDCA yield ($\text{■}$).

The catalytic behavior could be influenced by the presence of CeO₂ and its redox nature, acidity, and textural properties, or by gold dispersion. Considering ZrO₂ irreducible, the catalysts' oxygen mobility should arise from CeO₂ and collaborative CeO₂-Au or Ce-Zr-O interactions.

The oxygen storage ability can be quantified by means of oxygen storage capacity (OSC) and oxygen storage complete capacity (OSCC) measurements. The OSCC offers information about the total oxygen species available within the sample and is estimated from the formed CO₂ during 10 consecutive CO pulses. On the other hand, OSC corresponds to the most accessible species and is calculated from the average of CO₂ species formed under sample's exposure to consecutive CO – O₂ pulse sequences. The redox processes involved in the oxygen storage are:

$\begin{array}{l}\text{Ce}{\text{O}}_2+\text{xCO}\to \text{Ce}{\text{O}}_{2-\text{x}}+\text{xC}{\text{O}}_2(\text{reduction})\\ 2\text{Ce}{\text{O}}_{2-\text{x}}+{\text{O}}_2\to 2\text{Ce}{\text{O}}_2(\text{oxidation})\\ \text{C}{\text{e}}_{\text{x}}\text{Z}{\text{r}}_{1-\text{x}}{\text{O}}_2+\text{δCO}\to \text{C}{\text{e}}_{\text{x}}\text{Z}{\text{r}}_{1-\text{x}}{\text{O}}_{2-\text{δ}}+\text{δC}{\text{O}}_2(\text{reduction})\\ \text{C}{\text{e}}_{\text{x}}\text{Z}{\text{r}}_{1-\text{x}}{\text{O}}_{2-\text{δ}}+{\text{O}}_2\to \text{C}{\text{e}}_{\text{x}}\text{Z}{\text{r}}_{1-\text{x}}{\text{O}}_2(\text{oxidation})\end{array}$

The OSCC measurements expressed in μmol formed CO₂ are presented in Figure 6. For the bare supports, the measured temperatures are 200 and 250°C, whereas for the catalysts are 70°C (the reaction temperature) and 200°C (a temperature that allows support/catalyst comparison). As a general trend, the increase of the temperature increases the OSCC value. The bare support follows the O₂ mobility trend Ce > Ce50Zr > Ce25Zr at 200°C and Ce50Zr ~ Ce>> Ce25Zr at 250°C. Zirconia presence improves ceria's oxygen mobility, being the Ce50Zr the optimal composition, in agreement with TPR analysis, where zirconium introduction caused an increase of the reducibility of the system.

FIGURE 6

Figure 6. OSCC for the supports (A, 200 and 250°C) and for the catalysts (B, 70 °C and 200°C).

The oxygen mobility is promoted even more in the presence of gold, being noticeable even at 70°C (reaction temperature). Here the tendency differs from that of supports, being AuCe50Zr > AuCe > AuCe25Zr the one at low temperatures and AuCe50Zr > AuCe25Zr > AuCe at high temperatures. The latter is consistent with previous studies, in which it was demonstrated that the oxygen storage capacity depends on zirconia content and a maximal value is obtained for 25–50 mol% of Zr (Kaspar et al., 1999). Considering only the OSCC at the reaction temperature (70°C), the oxygen mobility does not correspond to the observed activity. If we consider the information received by the OSC measurements, the number of the atomic oxygen layers (NL) directly involved in the process can be calculated, according to Equation 6.

$\begin{array}{ll}NL=\frac{OS{C}_{experimental}}{OS{C}_{surface}}.& (6)\end{array}$

where OSC_experimental is the that obtained experimentally and OSC_surface accounts for the theoretically reducible oxygen on the surface. The OSC_surface is calculated by equation 7.

$\begin{array}{ll}OS{C}_{surface}\mu molC{O}_2{g}^{-1}=N_{0}x{S}_{BET}x\frac{1}{N_A}x\frac{1}{a^2}x10^6.& (7)\end{array}$

where S_BET is the specific surface area of the sample, N_A is Avogadro's number, a is the ceria lattice parameter (5.413 Å) and N₀ is the number of oxygen atoms of the ceria lattice that participate in the process. This number depends on the exposed CeO₂ lattice planes. In this study an average of the exposed oxygen from the (001), (110), and (111) faces has been assumed for the calculations resulting in a N₀ value of 1. Indeed, only one oxygen is participating in both redox processes expressed above. It is worth to clarify that NL <1 means that only oxygen from the surface is playing a role in the reduction process while NL >1 indicates the participation of bulk oxygen.

The calculations of OSC are based on the methodology proposed by Madier et al. (1999). More precisely, it is considered that (i) only oxygen atoms bonded to cerium participate in the storage process; (ii) the surface is homogeneous (iii) only one of four oxygen atoms is involved in the storage (CeO₂ Ce₂O₃ + “O”); and (iv) null gold metal contribution to the reduction, e.g., the gold metal cannot re-oxidize. For the OSC theoretical calculations, the number of surface oxygen atoms and BET area of each sample are considered.

For the supports (Table 3), similar to OSCC higher the temperature higher the fraction of layer (and therefore the OSC) involved in the reduction. Similarly to OSCC, the OSC decreases in order Ce > Ce50Zr > Ce25Zr at 200 and 250°C. The addition of gold changes dramatically the oxygen mobility at 200°C (Table 4) as well as the OSC tendency. At the reaction temperature, the oxygen dynamics is 16 times higher for AuCe50Zr that for the support at 200°C. The oxygen involved in the OSC is the surface oxygen (NL < 1) for the majority of samples no matter the temperature, exception made by AuCe50Zr at 200°C where the bulk oxygen also participates.

TABLE 3

Table 3. Oxygen storage capacity (OSC), expressed as (μmol CO₂/g), and number of oxygen layers (NL) for the supports as a function of the temperature.

TABLE 4

Table 4. Oxygen storage capacity (OSC), expressed as (μmol CO₂/g), and number of oxygen layers (NL) for the catalysts as a function of the temperature.

The trend found for oxygen mobility AuCe50Zr > AuCe > AuCe25Zr, differs from the activity relation. Therefore, although the ability of the support to transfer oxygen could influence the activity, is neither the only factor involved nor the most important one. It is logical to consider that the catalytic activity is affected by a combination of other factors.

The chemical composition of the samples is very similar to a series of catalysts prepared over commercial supports in our previous study (Megías-Sayago et al., 2018). But the activity order in this study do not repeat the order in the previous study, and lower yields of FDCA are produced. If we suppose that, their acid properties are comparable (same Ce/Zr ratio) the difference in activity could be due either to a difference in gold particle size or to catalysts textural properties.

If we compare both series (over commercial Megías-Sayago et al., 2018 and homemade supports) considering dispersion, pore size and volume, acidity, redox properties, and FDCA yield we should be able to conclude on the parameter that influences the activity in greater extent (Figure 7). The data used for this figure are listed in supporting information (Table S1).

FIGURE 7

Figure 7. Multiple parameters plot over the as prepared series and a series over commercial supports (Megías-Sayago et al., 2018).

The dispersion of gold and the redox properties of the supports (expressed as NL number) do to not fit very well the observed yields, however, the acidity and especially the textural properties, pore size, and volume suits the observed trend. The samples separate in two groups, the commercial with higher pore diameter producing higher FDCA yields, and the samples from this study, with half of pores diameter and lower FDCA yield. It is very interesting to underline that the AuCe sample from the actual series presents higher pore size and as a consequence present activity closer to the group of the commercial samples.

The obtained relation suggests that (i) gold nanoparticles may be located in the pores (ii) the FDCA production occurs in the pores. Both suggestions imply that in small pores solids diffusional limitations could appear.

Deducing which diffusion step is the limiting one is very difficult, due to the multiple mass-transfer processes involved in the reaction, such as (i) the oxygen dissolution in the HMF solution (gas-liquid transfer); (ii) the oxygen and reactants diffusion from the liquid bulk toward the outer surface of the catalyst grain (external diffusion); (iii) the transfer of the substrates from the outer surface inside the catalyst pores toward active sites of the reaction (internal reactant diffusion) and (iv) the transport of the reaction product from the pores to the outer surface of the catalyst grain (internal product diffusion).

In order to verify the presence of external diffusional limitations, different experiments were carried out by changing the stirring rates, at 200 and 600 rpm over both AuCe50Zr and AuCe25Zr samples (Figure 8).

FIGURE 8

Figure 8. Stirring rate dependence of FDCA yield. (A) AuCe50Zr and (B) AuCe25Zr. Reaction conditions: HMF:Au:NaOH molar ratio 1:0.01:2, 10 bar O₂, 70°C.

In both cases the FDCA yield decreases at 200 rpm (5%), resulting also in an important carbon loss of 40–45%. It seems that the low stirring rate prevents the proper diffusion of the HMF molecule to the active sites, being promoted the HMF degradation (via Cannizzaro reaction), resulting in byproducts formation and low carbon balance. Increasing the stirring rate to 600 rpm causes a slight increase of FDCA yield. However, the yields of the FDCA are still lower than those over commercial supports suggesting internal diffusion being present and indicating that an optimal pore size is necessary for the reaction (being the minimum size situated around 12 nm).

It has been demonstrated previously, that the surface Brönsted acidity of gold supported on Ce_xZr_1−xO₂ oxides plays a pivotal role in the reaction mechanism, being extremely beneficial for the FDCA production. We can assume that increasing the Zr/Ce ratio increases the number of surface hydroxyl groups, deprotonated in basic medium, and also promotes the formation of the alkoxy intermediate of HMFCA, favoring FFCA formation and, therefore, the total oxidation toward FDCA (Megías-Sayago et al., 2018). However, for this mechanism to occur the distribution of the support's non-isolated Brönsted sites situated in the vicinity of gold metal sites have to be fully accessible for adsorption/desorption which is only possible for specific pore size and volume. It seems that 12 nm pore size is the minimum size needed to avoid any of the mass-transfer processes involved, being possible to establish it as a general requirement for the liquid phase HMF oxidation.

Conclusions

A series of gold catalysts supported on metal oxides have been prepared and tested in HMF oxidation reaction. All catalysts exhibit high catalytic activity (100% HMF conversion) and important selectivity to FDCA. The bare supports do not participate in the reaction; only byproducts via Cannizzaro reaction are formed. However, when gold is present the HMF conversion reaches 100% without byproducts formation. Products distribution changes with the support change as expected, however, the observed trend cannot be related to gold particle size or support redox properties. The Brönsted acidity of the samples is very important for the mechanism of reaction, however the reaction is limited by the catalysts pore size and a minimum pore size of 12 nm is established to avoid internal diffusional limitations during the oxidation process.

Data Availability Statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation, to any qualified researcher.

Author Contributions

CM-S: Conceptualization, methodology, data curation, formal analysis, visualization, investigation, writing-original draft, writing-review, and editing. DB: Methodology, data curation, and formal analysis. AL: Supervision, validation, and investigation. SI: Supervision, conceptualization, methodology, data curation, formal analysis, visualization, investigation, writing-review, and editing. SA and FC: Supervision and validation. JO: Supervision, validation, and funding acquisition.

Funding

Financial support for this work has been obtained from the Spanish Ministerio de Economía y Competitividad (MINECO) (Project ENE2017-82451-C3-3-R) co-financed by FEDER funds from European Union.

Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Supplementary Material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fchem.2020.00461/full#supplementary-material

References

Ait Rass, H., Essayem, N., and Besson, M. (2015). Selective aerobic oxidation of 5-HMF into 2,5-furandicarboxylic acid with Pt catalysts supported on TiO2- and ZrO2-based selective aerobic oxidation of 5-HMF into 2,5-furandicarboxylic acid with Pt catalysts supported. ChemSusChem. 8, 1206–1217. doi: 10.1002/cssc.201403390

PubMed Abstract | CrossRef Full Text | Google Scholar

Albonetti, S., Lolli, A., Morandi, V., Migliori, A., Lucarelli, C., and Cavani, F. (2015). Conversion of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid over Au-based catalysts: optimization of active phase and metal – support interaction. Appl. Catal. B Environ. 163, 520–530. doi: 10.1016/j.apcatb.2014.08.026

CrossRef Full Text | Google Scholar

Albonetti, S., Pasini, T., Lolli, A., Blosi, M., Piccinini, M., Dimitratos, N., et al. (2012). Selective oxidation of 5-hydroxymethyl-2-furfural over TiO 2 -supported gold – copper catalysts prepared from preformed nanoparticles: effect of Au / Cu ratio. Catal. Today 195, 120–126. doi: 10.1016/j.cattod.2012.05.039

CrossRef Full Text | Google Scholar

Ardemani, L., Cibin, G., Dent, A. J., Isaacs, M. A., Kyriakou, G., Lee, A. F., et al. (2015). Solid base catalysed 5-HMF oxidation to 2,5-FDCA over Au/hydrotalcites: fact or fiction? Chem. Sci. 6, 4940–4945. doi: 10.1039/C5SC00854A

CrossRef Full Text | Google Scholar

Burgess, S. K., Leisen, J. E., Kraftschik, B. E., and Mubarak, C. R. (2014). Chain mobility, thermal, and mechanical properties of poly(ethylene furanoate) compared to poly(ethylene terephthalate). Macromolecules 47, 1383–1391. doi: 10.1021/ma5000199

CrossRef Full Text | Google Scholar

Casanova, O., Iborra, S., and Corma, A. (2009). Biomass into chemicals : aerobic oxidation of 5-hydroxy- methyl-2-furfural into 2,5-furandicarboxylic acid with gold nanoparticle catalysts. ChemSusChem 2, 1138–1144. doi: 10.1002/cssc.200900137

PubMed Abstract | CrossRef Full Text | Google Scholar

Davis, S. E., Houk, L. R., Tamargo, E. C., Datye, A. K., and Davis, R. J. (2011). Oxidation of 5-hydroxymethylfurfural over supported Pt, Pd and Au catalysts. Catal. Today 160, 55–60. doi: 10.1016/j.cattod.2010.06.004

CrossRef Full Text | Google Scholar

Davis, S. E., Zope, B. N., and Davis, R. J. (2012). On the mechanism of selective oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid over supported Pt and Au catalysts. Green Chem. 14, 143–147. doi: 10.1039/C1GC16074E

CrossRef Full Text | Google Scholar

Du, J., Fang, H., Qu, H., Zhang, J., Duan, X., and Yuan, Y. (2018). Fabrication of supported Au-CuOx nanohybrids by reduction-oxidation strategy for efficient oxidative esterification of 5-hydroxymethyl-2-furfural into dimethyl furan-2,5-dicarboxylate. Appl. Catal. A Gen. 567, 80–89. doi: 10.1016/j.apcata.2018.09.004

CrossRef Full Text | Google Scholar

Ferraz, C. P., Zielinski, M., Pietrowski, M., Heyte, S., Dumeignil, F., Rossi, L. M., et al. (2018). Influence of support basic sites in green oxidation of biobased substrates using Au-promoted catalysts. ACS Sustain. Chem. Eng. 6, 16332–16340. doi: 10.1021/acssuschemeng.8b03330

CrossRef Full Text | Google Scholar

Gandini, A. A., Silvestre, J. D., Neto, C. P., Sousa, A. F., and Gomes, M. (2008). The furan counterpart of poly(ethylene terephthalate): an alternative material based on renewable resources. J. Polym. Sci. A Polym. Chem. 47, 295–298. doi: 10.1002/pola.23130

CrossRef Full Text | Google Scholar

Gutiérrez-ortiz, J. I., De Rivas, B., López-fonseca, R., and González-Velasco, J. R. (2004). Combustion of aliphatic C2 chlorohydrocarbons over ceria – zirconia mixed oxides catalysts. Appl. Catal. A Gen. 269, 147–155. doi: 10.1016/j.apcata.2004.04.014

CrossRef Full Text | Google Scholar

Han, X., Geng, L., Guo, Y., Jia, R., Liu, X., Zhang, Y., et al. (2016). Base-free aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid over a Pt/C–O–Mg catalyst. Green Chem. 18, 1597–1604. doi: 10.1039/C5GC02114F

CrossRef Full Text | Google Scholar

Hernández, W. Y., Romero-Sarria, F., Centeno, M. Á., and Odriozola, J. A. (2010). in situ characterization of the dynamic gold–support interaction over ceria modified Eu3+. Influence of the oxygen vacancies on the CO oxidation reaction. J. Phys. Chem. C 114, 10857–10865. doi: 10.1021/jp1013225

CrossRef Full Text | Google Scholar

Ivanova, S., Petit, C., and Pitchon, V. (2004). A new preparation method for the formation of gold nanoparticles on an oxide support. Appl. Catal. A Gen. 267, 191–201. doi: 10.1016/j.apcata.2004.03.004

CrossRef Full Text | Google Scholar

Jacobs, G., Chenu, E., Patterson, P. M., Williams, L., Sparks, D., Thomas, G., et al. (2004). Water-gas shift: comparative screening of metal promoters for metal/ceria systems and role of the metal. Appl. Catal. A Gen. 258, 203–214. doi: 10.1016/j.apcata.2003.09.007

CrossRef Full Text | Google Scholar

Kacimi, S. J. B. Jr., Taha, R., and Duprez, D. (1993). Oxygen storage capacity of promoted Rh/CeC2 catalysts. Exceptional behavior of RhCu/CeO2. Catal. Lett. 22, 343–350. doi: 10.1007/BF00807243

CrossRef Full Text | Google Scholar

Kaspar, J., Fornasiero, P., and Graziani, M. (1999). Use of CeO2-based oxides in the three-way catalysis. Catal. Today 50, 285–298. doi: 10.1016/S0920-5861(98)00510-0

CrossRef Full Text | Google Scholar

Kondo, J., Sakata, Y., Domen, K., Maruya, K., and Onishi, T. (1990). Infrared study of hydrogen adsorbed on ZrO2. J. Chem. Soc. Faraday Trans. 86, 397–401. doi: 10.1039/ft9908600397

CrossRef Full Text | Google Scholar

Letichevsky, S., Tellez, C. A., De Avillez, R. R., Isabel, M., Silva, P., Fraga, M. A., et al. (2005). Obtaining CeO2 – ZrO2 mixed oxides by coprecipitation: role of preparation conditions. Appl. Catal. B Environ. 58, 203–210. doi: 10.1016/j.apcatb.2004.10.014

CrossRef Full Text | Google Scholar

Liu, B., Rena, Y., and Zhang, Z. (2015). Aerobic oxidation of 5-hydroxymethylfurfural into 2,5-furandicarboxylic acid in water under mild conditions. Green Chem. 17, 1610–1617. doi: 10.1039/C4GC02019G

CrossRef Full Text | Google Scholar

Lolli, A., Albonetti, S., Utili, L., Amadori, R., Ospitali, F., Lucarelli, C., et al. (2015). Insights into the reaction mechanism for 5-hydroxymethylfurfural oxidation to FDCA on bimetallic Pd – Au nanoparticles. Appl. Catal. A Gen. 504, 408–419. doi: 10.1016/j.apcata.2014.11.020

CrossRef Full Text | Google Scholar

Madier, Y., Descorme, C., Le Govic, A. M., and Duprez, D. (1999). Oxygen mobility in CeO2 and CexZr(1-x)O2 compounds: study by CO transient oxidation and 18O/16O isotopic exchange. J. Phys. Chem. B 103, 10999–11006. doi: 10.1021/jp991270a

CrossRef Full Text | Google Scholar

Masoud, N., Donoeva, B., and Jongh, P. E. (2018). Stability of gold nanocatalysts supported on mesoporous silica for the oxidation of 5-hydroxymethyl furfural to furan-2,5-dicarboxylic acid. Appl. Catal. A Gen. 561, 150–157. doi: 10.1016/j.apcata.2018.05.027

CrossRef Full Text | Google Scholar

Megías-Sayago, C., Chakarova, K., Penkova, A., Lolli, A., Ivanova, S., Albonetti, S., et al. (2018). Understanding the role of the acid sites in 5-hydroxymethylfurfural oxidation to 2,5-furandicarboxylic acid reaction over gold catalysts: surface investigation on CexZr1–xO2 compounds. ACS Catal. 8, 11154–11164. doi: 10.1021/acscatal.8b02522

CrossRef Full Text | Google Scholar

Menegazzo, F., Signoretto, M., Marchese, D., Pinna, F., and Manzoli, M. (2015). Structure–activity relationships of Au/ZrO2 catalysts for 5-hydroxymethylfurfural oxidative esterification: effects of zirconia sulphation on gold dispersion, position and shape. J. Catal. 326, 1–8. doi: 10.1016/j.jcat.2015.03.006

CrossRef Full Text | Google Scholar

Nie, J., Xie, J., and Liu, H. (2013). Efficient aerobic oxidation of 5-hydroxymethylfurfural to 2,5-diformylfuran on supported Ru catalysts. J. Catal. 301, 83–91. doi: 10.1016/j.jcat.2013.01.007

CrossRef Full Text | Google Scholar

Pasini, T., Piccinini, M., Blosi, M., Bonelli, R., Albonetti, S., Dimitratos, N., et al. (2011). Selective oxidation of 5-hydroxymethyl-2-furfural using supported. Green Chem. 13, 2091–2099. doi: 10.1039/c1gc15355b

CrossRef Full Text | Google Scholar

Reina, T. R., Ivanova, S., Idakiev, V., Delgado, J. J., Ivanov, I., Tabakova, T., et al. (2013). Impact of Ce–Fe synergism on the catalytic behaviour of Au/CeO2–FeOx/Al2O3 for pure H2 production. Catal. Sci. Technol. 3, 779–787. doi: 10.1039/C2CY20537H

CrossRef Full Text | Google Scholar

Royer, S., and Duprez, D. (2011). Catalytic oxidation of carbon monoxide over transition metal oxides. ChemCatChem 3, 24–65. doi: 10.1002/cctc.201000378

CrossRef Full Text | Google Scholar

Siankevich, S., Savoglidis, G., Fei, Z., Laurenczy, G. D., Alexander, T. L., Yan, N., et al. (2014). A novel platinum nanocatalyst for the oxidation of 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic acid under mild conditions. J. Catal. 315, 67–74. doi: 10.1016/j.jcat.2014.04.011

CrossRef Full Text | Google Scholar

Siyo, B., Schneider, M., Radnik, J., Pohl, M.-M., Langer, P., and Steinfeldt, N. (2014). Influence of support on the aerobic oxidation of HMF into FDCA over preformed Pd nanoparticle based materials. Appl. Catal. A 478, 107–116. doi: 10.1016/j.apcata.2014.03.020

CrossRef Full Text | Google Scholar

Thammachart, M., Meeyoo, V., Risksomboon, T., and Osuwan, S. (2001). Catalytic activity of CeO2–ZrO2 mixed oxide catalysts prepared via sol–gel technique: CO oxidation. Catal. Today 68, 53–61. doi: 10.1016/S0920-5861(01)00322-4

CrossRef Full Text | Google Scholar

Yi, G., Teong, S. P., and Zhang, Y. (2016). Base-free conversion of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid over a Ru/C catalyst. Green Chem. 18, 979–983. doi: 10.1039/C5GC01584G

CrossRef Full Text | Google Scholar

Zhang, Z., and Deng, K. (2015). Recent advances in the catalytic synthesis of 2,5-furandicarboxylic acid and its derivatives. ACS Catal. 5, 6529–6544. doi: 10.1021/acscatal.5b01491

CrossRef Full Text | Google Scholar

Zhang, Z., Zhen, J., Liu, B., Lv, K., and Deng, K. (2015). Selective aerobic oxidation of the biomass-derived precursor 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid under mild conditions over a magnetic palladium nanocatalyst. Green Chem. 17, 1308–1317. doi: 10.1039/C4GC01833H

CrossRef Full Text | Google Scholar

Zope, B. N., Hibbitts, D. D., Neurock, M., and Davis, R. J. (2010). Reactivity of the gold / water interface during selective oxidation catalysis. Science 533, 74–79. doi: 10.1126/science.1195055

PubMed Abstract | CrossRef Full Text | Google Scholar