3xtg Ad Mice | List of Frontiers open access articles

Original Research

Published on 13 Aug 2021

IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer’s Disease Associated With Brain Weight

in Alzheimer's Disease and Related Dementias

Wendy Winslow
Ian McDonough
Savannah Tallino
Annika Decker
Austin S. Vural
Ramon Velazquez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.720214

6,444 views
24 citations

Original Research

Published on 18 Dec 2024

Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease

in Neurocognitive Aging and Behavior

Jessica M. Judd
Wendy Winslow
Ian McDonough
Faizan Mistry
Ramon Velazquez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1466415

2,399 views
2 citations

Original Research

Published on 06 Mar 2024

Slowing Alzheimer’s disease progression through probiotic supplementation

in Gut-Brain Axis

Destynie Medeiros
Kristina McMurry
Melissa Pfeiffer
Kayla Newsome
Todd Testerman
Joerg Graf
Adam C. Silver
Paola Sacchetti

Frontiers in Neuroscience

doi 10.3389/fnins.2024.1309075

9,215 views
15 citations

Original Research

Published on 12 Jun 2018

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

in Alzheimer's Disease and Related Dementias

Alice E. Kane
Sooyoun Shin
Aimee A. Wong
Emre Fertan
Natalia S. Faustova
Susan E. Howlett
Richard E. Brown

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2018.00172

9,772 views
62 citations

Original Research

Published on 27 Jan 2022

Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease

in Alzheimer's Disease and Related Dementias

Jana Tureckova
Monika Kamenicka
Denisa Kolenicova
Tereza Filipi
Zuzana Hermanova
Jan Kriska
Lenka Meszarosova
Barbora Pukajova
Lukas Valihrach
Peter Androvic

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.783120

6,919 views
8 citations

Original Research

Published on 18 Jan 2021

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

in Individual and Social Behaviors

Lydia Gimenez-Llort
Daniel Alveal-Mellado

Frontiers in Behavioral Neuroscience

doi 10.3389/fnbeh.2020.611384

6,300 views
15 citations

Original Research

Published on 19 Mar 2021

Translational Modeling of Psychomotor Function in Normal and AD-Pathological Aging With Special Concerns on the Effects of Social Isolation

in Interventions in Aging

Lidia Castillo-Mariqueo
Lydia Giménez-Llort

Frontiers in Aging

doi 10.3389/fragi.2021.648567

4,053 views
8 citations

Brief Research Report

Published on 15 Sep 2022

Crosstalk of Alzheimer’s disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach

in Alzheimer's Disease and Related Dementias

Aida Muntsant
Lydia Giménez-Llort

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.969381

6,500 views
16 citations

Original Research

Published on 29 Apr 2021

Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer’s Disease

in Neuroenergetics and Brain Health

Paola C. Bello-Medina
Fernando Hernández-Quiroz
Marcel Pérez-Morales
Diego A. González-Franco
Guadalupe Cruz-Pauseno
Jaime García-Mena
Sofía Díaz-Cintra
Gustavo Pacheco-López

Frontiers in Neuroscience

doi 10.3389/fnins.2021.595583

9,052 views
41 citations

Brief Research Report

Published on 20 Jul 2021

Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers

in Neurocognitive Aging and Behavior

Toni Cañete
Lydia Giménez-Llort

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.683412

3,979 views
7 citations

Original Research

Published on 11 Oct 2022

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

in Reproduction

Szidónia Farkas
Adrienn Szabó
Bibiána Török
Csenge Sólyomvári
Csilla Lea Fazekas
Krisztina Bánrévi
Pedro Correia
Tiago Chaves
Dóra Zelena

Frontiers in Endocrinology

doi 10.3389/fendo.2022.985424

7,949 views
11 citations

Original Research

Published on 05 May 2020

Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice

in Alzheimer's Disease and Related Dementias

Amy Christensen
Jiahui Liu
Christian J. Pike

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.00113

6,272 views
18 citations

Original Research

Published on 29 Jul 2022

Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice

in Alzheimer's Disease and Related Dementias

Pavithra Suresh
Sureka Jasmin
Yun Yen
Hao-Jen Hsu
Peeraporn Varinthra
Tanita Pairojana
Chien-Chang Chen
Ingrid Y. Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2022.916904

4,318 views
5 citations

Original Research

Published on 30 May 2014

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

in Alzheimer's Disease and Related Dementias

Yanxing Chen
Xiaoqin Run
Zhihou Liang
Yang Zhao
Chun-ling Dai
Khalid Iqbal
Fei Liu
Cheng-Xin Gong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2014.00100

8,387 views
45 citations

Original Research

Published on 10 Sep 2014

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice

in Alzheimer's Disease and Related Dementias

John F. Castro-Alvarez
S. Alejandro Uribe-Arias
Kenneth S. Kosik
Gloria P. Cardona-Gómez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2014.00243

6,228 views
39 citations

Original Research

Published on 15 Mar 2021

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease

in Molecular and Cellular Pathology

Xianfeng Huang
Jinyao Yang
Xi Huang
Zaijun Zhang
Jianjun Liu
Liangyu Zou
Xifei Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.632843

7,569 views
36 citations

Articles

IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer’s Disease Associated With Brain Weight

Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease

Slowing Alzheimer’s disease progression through probiotic supplementation

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease

Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born

Translational Modeling of Psychomotor Function in Normal and AD-Pathological Aging With Special Concerns on the Effects of Social Isolation

Crosstalk of Alzheimer’s disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach

Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer’s Disease

Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers

Ovariectomy-induced hormone deprivation aggravates Aβ1-42 deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer’s disease

Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice

Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease