Antibody Humanization | List of Frontiers open access articles

Review

Published on 16 Oct 2018

Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

in Vaccines and Molecular Therapeutics

Mathieu Dondelinger
Patrice Filée
Eric Sauvage
Birgit Quinting
Serge Muyldermans
Moreno Galleni
Marylène S. Vandevenne

Frontiers in Immunology

doi 10.3389/fimmu.2018.02278

96,461 views
103 citations

Original Research

Published on 24 Nov 2020

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

in Structural Biology

Monica L. Fernández-Quintero
Katharina B. Kroell
Martin C. Heiss
Johannes R. Loeffler
Patrick K. Quoika
Franz Waibl
Alexander Bujotzek
Ekkehard Moessner
Guy Georges
Klaus R. Liedl

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2020.609088

6,022 views
22 citations

Original Research

Published on 02 Sep 2022

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

in B Cell Biology

Monica L. Fernández-Quintero
Anna-Lena M. Fischer
Janik Kokot
Franz Waibl
Clarissa A. Seidler
Klaus R. Liedl

Frontiers in Immunology

doi 10.3389/fimmu.2022.953917

6,326 views
16 citations

Original Research

Published on 15 Jul 2024

Comparison of “framework Shuffling” and “CDR Grafting” in humanization of a PD-1 murine antibody

in B Cell Biology

Yongmei Wang
Yi-Li Chen
Hui Xu
Gul E. Rana
Xiaorong Tan
Mengying He
Qingqing Jing
Qi Wang
Guifeng Wang
Zuoquan Xie

Frontiers in Immunology

doi 10.3389/fimmu.2024.1395854

7,834 views
7 citations

Original Research

Accepted on 10 Oct 2025

Framework humanization enhances GM3(Neu5Gc)-targeting CAR-T cell function by reducing tonic signaling

in Cancer Immunity and Immunotherapy

Jiaxin Tu
Xinyu Li
Yuge Zhu
Shance Li
Guanyu Zhang
You He
Chaoting Zhang
Zheming Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697732

154 views

Original Research

Published on 02 Oct 2023

The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling

in Cancer Immunity and Immunotherapy

Song Li
Dianze Chen
Huiqin Guo
Dandan Liu
Chunmei Yang
Ruliang Zhang
Tianxiang Wang
Fan Zhang
Xing Bai
Yanan Yang

Frontiers in Oncology

doi 10.3389/fonc.2023.1240061

5,380 views
9 citations

Articles

Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

Surprisingly Fast Interface and Elbow Angle Dynamics of Antigen-Binding Fragments

The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles

Comparison of “framework Shuffling” and “CDR Grafting” in humanization of a PD-1 murine antibody

Framework humanization enhances GM3(Neu5Gc)-targeting CAR-T cell function by reducing tonic signaling

The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling