Interferonopathy | List of Frontiers open access articles

Original Research

Published on 04 Sep 2025

Novel USP18 mutations lead to severe interferonopathy responsive to JAK inhibitor

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Xiangwei Sun
Ming Li
Yiying Dou
Qintao Wang
Jianming Lai
Jia Zhu
Qing Zhou
Xiaomin Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646996

1,318 views

Original Research

Published on 05 Nov 2021

Changes in MDA5 and TLR3 Sensing of the Same Diabetogenic Virus Result in Different Autoimmune Disease Outcomes

in Immunological Tolerance and Regulation

Pamela J. Lincez
Iryna Shanina
Marc S. Horwitz

Frontiers in Immunology

doi 10.3389/fimmu.2021.751341

3,218 views
9 citations

Original Research

Published on 21 Feb 2025

Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome

in Primary Immunodeficiencies

Tamar Rubin
Stéphane Bernier
Lily Siok Hoon Lim
Michael S. Salman
Edward Leung
Aziz Mhanni
Sandra Marles
Cheryl Greenberg
Anna Perez
Yichun Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1557632

2,810 views
1 citation

Review

Published on 15 Jan 2021

Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy

in Inflammation

Holly A. Rutherford
Paul R. Kasher
Noémie Hamilton

Frontiers in Immunology

doi 10.3389/fimmu.2020.623650

6,005 views
10 citations

Brief Research Report

Published on 06 Mar 2023

Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Sarah E. Withers
Charlie F. Rowlands
Victor S. Tapia
Frances Hedley
Ioana-Emilia Mosneag
Siobhan Crilly
Gillian I. Rice
Andrew P. Badrock
Andrew Hayes
Stuart M. Allan

Frontiers in Immunology

doi 10.3389/fimmu.2023.1100967

4,720 views
6 citations

Mini Review

Published on 26 Aug 2021

Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease

in Cytokines and Soluble Mediators in Immunity

Alice Lepelley
Timothy Wai
Yanick J. Crow

Frontiers in Immunology

doi 10.3389/fimmu.2021.729763

11,231 views
26 citations

Original Research

Published on 24 Nov 2023

A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Beatriz Bernal-Bermúdez
Alicia Martínez-López
Francisco J. Martínez-Morcillo
Sylwia D. Tyrkalska
Teresa Martínez-Menchón
Pablo Mesa-del-Castillo
María L. Cayuela
Victoriano Mulero
Diana García-Moreno

Frontiers in Immunology

doi 10.3389/fimmu.2023.1294766

4,285 views
2 citations

Review

Published on 26 Nov 2019

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)

in Autoimmune and Autoinflammatory Disorders

Frédéric Ebstein
María Cecilia Poli Harlowe
Maja Studencka-Turski
Elke Krüger

Frontiers in Immunology

doi 10.3389/fimmu.2019.02756

12,933 views
71 citations

Systematic Review

Published on 02 Sep 2025

Anti-MDA5+ dermatomyositis following SARS-COV-2 infections: a systematic review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Simone Lattarulo
Francesca Centrone
Maria Chironna

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565803

2,387 views

Articles

Novel USP18 mutations lead to severe interferonopathy responsive to JAK inhibitor

Changes in MDA5 and TLR3 Sensing of the Same Diabetogenic Virus Result in Different Autoimmune Disease Outcomes

Two rare mutations in homozygosity synergize to silence TREX1 in Aicardi-Goutières syndrome

Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy

Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome

Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease

A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)

Anti-MDA5+ dermatomyositis following SARS-COV-2 infections: a systematic review