Preclinical Stage | List of Frontiers open access articles

Original Research

Accepted on 04 Sep 2025

The Hidden in Plain Sight: Global, Regional, and National Trends in the Pediatric Burden of Klinefelter Syndrome, 1990–2021

in Applied Genetic Epidemiology

Guoqian Ma
Yuan Li
Fan Jia

Frontiers in Genetics

doi 10.3389/fgene.2025.1639699

155 views

Clinical Trial

Accepted on 04 Sep 2025

Task-Specific Cortical Mechanisms of taVNS-Paired Task-Oriented Training for Post-Stroke Upper Extremity Dysfunction Under Cognitive Load: An fNIRS Study

in Brain Imaging and Stimulation

Shiyi Li
Ke Xu
Yixiu Wang
Menghuan Wang
Shushan Li
Feng LIN
Zhongli Jiang

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2025.1652612

194 views

Editorial

Accepted on 04 Sep 2025

Editorial: Dopaminoceptive Forebrain Regions: A Search for Structural and Functional Organization Underlying Normal and Impaired Social Adaptation

Loreta Medina
Andras Csillag

Frontiers in Neuroanatomy

doi 10.3389/fnana.2025.1694730

Editorial

Accepted on 04 Sep 2025

Editorial: Nature-based solutions for climate change adaptation

in Interdisciplinary Climate Studies

Nalini S. Rao
Emma Ferranti
Andrea Ghermandi
Petina Pert

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1672694

199 views

Mini Review

Accepted on 04 Sep 2025

Ontogeny Specification and Epigenetic Regulation of Macrophage Plasticity

in Cancer Immunity and Immunotherapy

Hanying Huang
Xin-nan Zheng
Lin Tian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676953

174 views

Editorial

Accepted on 04 Sep 2025

Editorial: Robotics Software Engineering

in Computational Intelligence in Robotics

Federico Ciccozzi
Ivano Malavolta
Christopher Timperley
Andreas Angerer
Alwin Hoffmann

Frontiers in Robotics and AI

doi 10.3389/frobt.2025.1686496

Original Research

Accepted on 04 Sep 2025

Risk factors for first-trimester spontaneous abortion and the role of preconception care

in Maternal Health

Yuliya Podilyakina
Leila Stabayeva
Dusentay Kulov
Yevgeniy Kamyshanskiy
Zhanna Amirbekova
Rasa Stundžienė
Olzhas Zhamantayev

Frontiers in Global Women's Health

doi 10.3389/fgwh.2025.1615983

120 views

Original Research

Accepted on 04 Sep 2025

Preliminary study on BRICS sequential therapeutic regimen as salvage treatment for refractory advanced colorectal cancer patients harboring pMMR status

in Cancer Immunity and Immunotherapy

Yonghai Peng
Jian Wang
Junhui Wang
Jianxin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670812

150 views

Review

Accepted on 04 Sep 2025

Lung cancer associated with cystic airspaces: current progress and future perspectives

in Oncology Reviews: Reviews

Jiarui Wang
Jie Dai

Oncology Reviews

doi 10.3389/or.2025.1615365

106 views

Original Research

Accepted on 04 Sep 2025

Combination Therapy with Nisin, Urolithin B, and Vincristine Exhibits Synergistic Antiproliferative and Pro-Apoptotic Effects Against Human Lymphoma Cells: Evidence From Proteomics

in Cancer Immunity and Immunotherapy

Ahmad Al-Khazaleh
Muhammad A Alsherbiny
Dennis Chang
Gerald Muench
Deep Jyoti Bhuyan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664468

Original Research

Accepted on 04 Sep 2025

Predictive Factors and Outcomes of Immune-Related Adverse Events in Chinese Patients Treated with Immune Checkpoint Inhibitors: A Real-World Retrospective Study

in Cancer Immunity and Immunotherapy

Haodong Kong
Rongjia Xie
Zhuqing Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655724

115 views

Original Research

Accepted on 04 Sep 2025

Deep Learning for 3D Reconstruction and Trajectory Prediction of Dust and Polluted Aerosols in Educational Environments

in Big Data, AI, and the Environment

Ruijuan Han

Frontiers in Environmental Science

doi 10.3389/fenvs.2025.1582806

236 views

Systematic Review

Accepted on 04 Sep 2025

A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD

in Pulmonary Medicine

Qi Muge
Suriguga Suriguga
Yuqing Yuqing
Aronggaowa Aronggaowa
Taojin Taojin
Lanying Chen

Frontiers in Medicine

doi 10.3389/fmed.2025.1640084

137 views

Original Research

Accepted on 04 Sep 2025

Associations of Nutritional Awareness, Body Mass Index, Mental Health, and Fitness Components Among Undergraduate University Students

in Nutrition, Psychology and Brain Health

Laila Fathi Zaid Alkilani
Salwa Saad Awad
Jozaa Z ALTamimi
Fatimah Sayer Alharbi

Frontiers in Nutrition

doi 10.3389/fnut.2025.1614296

186 views

Original Research

Accepted on 04 Sep 2025

Analysis of TGFβ1-Induced Activin A Gene Expression in Kidney Mesangial Cells

in Cellular Biochemistry

Asfia Soomro
Kennedy Nmecha
Jackie Trink
Renzhong Li
Joan Krepinsky

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1607043

107 views

Original Research

Accepted on 04 Sep 2025

The role of Intellectual Humility Leadership on Thriving at Work and Performance of New Generation Employees

in Organizational Psychology

Changchun Gao
Aiwen Niu
Chenhui Yu

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1673728

221 views

Articles

The Hidden in Plain Sight: Global, Regional, and National Trends in the Pediatric Burden of Klinefelter Syndrome, 1990–2021

Task-Specific Cortical Mechanisms of taVNS-Paired Task-Oriented Training for Post-Stroke Upper Extremity Dysfunction Under Cognitive Load: An fNIRS Study

Editorial: Dopaminoceptive Forebrain Regions: A Search for Structural and Functional Organization Underlying Normal and Impaired Social Adaptation

Editorial: Nature-based solutions for climate change adaptation

Ontogeny Specification and Epigenetic Regulation of Macrophage Plasticity

Editorial: Robotics Software Engineering

Risk factors for first-trimester spontaneous abortion and the role of preconception care

Preliminary study on BRICS sequential therapeutic regimen as salvage treatment for refractory advanced colorectal cancer patients harboring pMMR status

Lung cancer associated with cystic airspaces: current progress and future perspectives

Combination Therapy with Nisin, Urolithin B, and Vincristine Exhibits Synergistic Antiproliferative and Pro-Apoptotic Effects Against Human Lymphoma Cells: Evidence From Proteomics

Predictive Factors and Outcomes of Immune-Related Adverse Events in Chinese Patients Treated with Immune Checkpoint Inhibitors: A Real-World Retrospective Study

Deep Learning for 3D Reconstruction and Trajectory Prediction of Dust and Polluted Aerosols in Educational Environments

A meta-analysis of the effects of long-term oxygen therapy combined with exercise rehabilitation on exercise capacity, cardiopulmonary function, and quality of life in patients with COPD

Associations of Nutritional Awareness, Body Mass Index, Mental Health, and Fitness Components Among Undergraduate University Students

Analysis of TGFβ1-Induced Activin A Gene Expression in Kidney Mesangial Cells

The role of Intellectual Humility Leadership on Thriving at Work and Performance of New Generation Employees