With over 149,000 citations across more than 11,000 articles, Frontiers in Cell and Developmental Biology is the most cited journal in its field. Explore some of the journal's trending articles below.

Atorvastatin Induces Mitochondria-Dependent Ferroptosis via the Modulation of Nrf2-xCT/GPx4 Axis
This paper explores an innovative underlying pathophysiological mechanism of atorvastatin-induced myopathy and highlights that targeting ferroptosis serves as a protective strategy for clinical application.

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities
Study explores recent encouraging preclinical findings, discusses the apparent disagreement between preclinical and clinical results, and considers new opportunities to exploit the potential of integrin adhesion complexes as targets for cancer therapy.

Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration
Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in neural tissues. This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology.

Overcoming Cancer Drug Resistance Utilizing PROTAC Technology
This review focuses on analyzing the developments in PROTACs geared towards cancer resistance and targets that confer it in the search for new and successful therapies.

Extracellular Matrix Stiffness and TGFβ2 Regulate YAP/TAZ Activity in Human Trabecular Meshwork Cells
Study provides evidence for a pathologic role of aberrant YAP/TAZ signaling in glaucomatous HTM cell dysfunction, and may help inform strategies for the development of novel multifactorial approaches to prevent progressive ocular hypertension in glaucoma.

Cancer-associated fibroblasts: The chief architect in the tumor microenvironment
This reviews discusses the current understanding of the origin and heterogeneity of cancer-associated fibroblasts, their role in tumor progression, and altering the tumor response to therapeutic agents in breast cancer.

Cas13d: A New Molecular Scissor for Transcriptome Engineering
This review encompasses the structural and mechanistic properties of type VI CRISPR-Cas13d systems, an overview of the current reported various applications of Cas13d, and the prospects to improve Cas13d based tools for diagnostic and therapeutic purposes.

Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights
BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism. This review summarizes the clinical outcomes of the four FDA-approved PARPi in treating BRCA1/2 deficient cancers and more.

Mitochondrial calcium cycling in neuronal function and neurodegeneration
This review discusses the many roles of mitochondrial Ca2+ uptake and release mechanisms in normal neuronal function and highlight new insights into the Ca2+-dependent mechanisms that drive mitochondrial dysfunction in neurologic diseases.

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis
This review provides an in-depth overview of the characteristics of melanoma-derived EVs and their role in melanoma progression highlighting key advances and remaining open questions in the field.
Read other impactful articles published in Frontiers in Cell and Developmental Biology.