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ORIGINAL RESEARCH article
Front. Digit. Health
Sec. Health Informatics
Volume 6 - 2024 |
doi: 10.3389/fdgth.2024.1344103
Building National Patient Registries in Mexico: Insights from the MexOMICS Consortium. Short title: MexOMICS Consortium: National Patient Registries in Mexico
Provisionally accepted
Paula Reyes-Pérez
1*
Ana Laura Hernandez-Ledesma
1
Talía V. Román-López
2*
Brisa García-Vilchis
3*
Diego Ramírez-González
2
Alejandra Lázaro-Figueroa
3*
Domingo Martinez
1
Victor Flores-Ocampo
1*
Ian M. Espinosa-Méndez
2
Lizbet Tinajero-Nieto
4*
Angélica Peña-Ayala
4
Eugenia Morelos-Figaredo
5
Carlos M. Guerra-Galicia
6*
Estefania Torres-Valdez
7*
María Vanessa Gordillo-Huerta
8*
Nadia A. Gandarilla-Martínez
9*
Karla Salinas-Barboza
10*
Guillermo Félix-Rodríguez
11*
Gabriel Frontana-Vázquez
7
Yamil Matuk Perez
12
Ingrid Estrada-Bellmann
13
Deshire Alpizar-Rodriguez
14
Mayela Rodríguez-Violante
15
Miguel E. Rentería
16*
Alejandra E. Ruíz-Contreras
3*
Sarael Alcauter
2*
Alejandra Medina-Rivera
1*- 1 Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, Mexico
- 2 Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, National Autonomous University of Mexico, Juriquilla, Mexico
- 3 Faculty of Psychology, National Autonomous University of Mexico, Mexico City, México, Mexico
- 4 General Regional Hospital No.1 Dr. Carlos Mac Gregor Sanchez Navarro, Mexican Social Security Institute (IMSS), Mexico City, México, Mexico
- 5 Hospital regional 1° de Octubre ISSSTE, Mexico City, México, Mexico
- 6 Neurociencias PRISMA AC, San Luis Potosí, San Luis Potosí, Mexico
- 7 Independent researcher, Querétaro, Mexico
- 8 General Hospital Querétaro ISSSTE, Querétaro, Mexico
- 9 Centro Médico ABC, Mexico City, México, Mexico
- 10 General Hospital of Mexico, Mexico City, México, Mexico
- 11 Querétaro Star Medica Hospital, Queretaro, Mexico
- 12 Faculty of Medicine, Autonomous University of Querétaro, Querétaro, Mexico
- 13 Autonomous University of Nuevo León, San Nicolás de los Garza, Nuevo León4, Mexico
- 14 Colegio Mexicano de Reumatología AC, Mexico City, México, Mexico
- 15 Manuel Velasco Suárez National Institute of Neurology and Neurosurgery, Mexico City, México, Mexico
- 16 QIMR Berghofer Medical Research Institute, The University of Queensland, Herston, Queensland, Australia
To introduce MexOMICS, a Mexican Consortium focused on establishing electronic databases to collect, cross-reference, and share health-related and omics data on the Mexican population. METHODS: Since 2019, the MexOMICS Consortium has established three electronicbased registries: the Mexican Twin Registry (TwinsMX), Mexican Lupus Registry (LupusRGMX), and the Mexican Parkinson's Research Network (MEX-PD), designed and implemented using the Research Electronic Data Capture web-based application. Participants were enrolled through voluntary participation and on-site engagement with medical specialists. We also acquired DNA samples and Magnetic Resonance Imaging scans in subsets of participants. RESULTS: The registries have successfully enrolled a large number of participants from a variety of regions within Mexico: TwinsMX (n=2915), LupusRGMX (n=1761) and MEX-PD (n=750). In addition to sociodemographic, psychosocial, and clinical data, MexOMICS has collected DNA samples to study the genetic biomarkers across the three registries. Cognitive function has been assessed with the Montreal Cognitive Assessment in a subset of 376 MEX-PD participants. Furthermore, a subset of 267 twins have participated in cognitive evaluations with the Creyos platform and in MRI sessions acquiring structural, functional, and spectroscopy brain imaging; comparable evaluations are planned for LupusRGMX and MEX-PD. CONCLUSIONS: The MexOMICS registries offer a valuable repository of information concerning the potential interplay of genetic and environmental factors in health conditions among the Mexican population.
Keywords: keyword1, keyword2, keyword3, keyword4, keyword5. (Min.5-Max. 8)
Received: 27 Nov 2023; Accepted: 01 May 2024.
Copyright: © 2024 Reyes-Pérez, Hernandez-Ledesma, Román-López, García-Vilchis, Ramírez-González, Lázaro-Figueroa, Martinez, Flores-Ocampo, Espinosa-Méndez, Tinajero-Nieto, Peña-Ayala, Morelos-Figaredo, Guerra-Galicia, Torres-Valdez, Gordillo-Huerta, Gandarilla-Martínez, Salinas-Barboza, Félix-Rodríguez, Frontana-Vázquez, Matuk Perez, Estrada-Bellmann, Alpizar-Rodriguez, Rodríguez-Violante, Rentería, Ruíz-Contreras, Alcauter and Medina-Rivera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Paula Reyes-Pérez, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, Mexico
Talía V. Román-López, Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, National Autonomous University of Mexico, Juriquilla, Mexico
Brisa García-Vilchis, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, 04510, México, Mexico
Alejandra Lázaro-Figueroa, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, 04510, México, Mexico
Victor Flores-Ocampo, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, Mexico
Lizbet Tinajero-Nieto, General Regional Hospital No.1 Dr. Carlos Mac Gregor Sanchez Navarro, Mexican Social Security Institute (IMSS), Mexico City, 3103, México, Mexico
Carlos M. Guerra-Galicia, Neurociencias PRISMA AC, San Luis Potosí, San Luis Potosí, Mexico
Estefania Torres-Valdez, Independent researcher, Querétaro, Mexico
María Vanessa Gordillo-Huerta, General Hospital Querétaro ISSSTE, Querétaro, Mexico
Nadia A. Gandarilla-Martínez, Centro Médico ABC, Mexico City, México, Mexico
Karla Salinas-Barboza, General Hospital of Mexico, Mexico City, 06720, México, Mexico
Guillermo Félix-Rodríguez, Querétaro Star Medica Hospital, Queretaro, 76125, Mexico
Miguel E. Rentería, QIMR Berghofer Medical Research Institute, The University of Queensland, Herston, 4006, Queensland, Australia
Alejandra E. Ruíz-Contreras, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, 04510, México, Mexico
Sarael Alcauter, Department of Behavioral and Cognitive Neurobiology, Institute of Neurobiology, National Autonomous University of Mexico, Juriquilla, Mexico
Alejandra Medina-Rivera, Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, Mexico
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