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Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2018.00667

Zearalenone: a mycotoxin of stronger toxic effect in Equus asinus than in swine granulosa cells

Guoliang Zhang1, 2, Yulong Feng2,  Jun-Lin Song1* and Xiang-Shan Zhou2, 3*
  • 1Qingdao Agricultural University, China
  • 2National Engineering Research Center for Gelatin-based Traditional Chinese Medicine, China
  • 3State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (CAS), China

Zearalenone (ZEA), one of the most prevalent estrogenic mycotoxins, is mainly produced by Fusarium fungi and has been proven to affect the reproductive capacity of animals. Exposure of farm animals to ZEA is of public concern globally because of its toxicity and wide distribution in feeds. In vitro and in vivo experiments indicate that ZEA possesses estrogenic activity in mice, swine, Equus asinus, and cattle. The precise mechanism of the reproductive toxicity of ZEA has not been established yet. This article reviews evidence on the deleterious effects of ZEA on mammalian folliculogenesis from early to final oogenesis stages. Such effects include impaired granulosa cell (GC) development and follicle steroidogenesis, reduced oocyte nest breakdown, damaged meiotic progression, poor fetal oocyte survival, accelerated primordial follicle activation, , and enhanced follicle atresia. These phenomena may result in reproductive and non-reproductive problems in domestic animals. In addition, emerging data indicate that ZEA may cause mRNA expression changes in GCs. In general, E. asinus is more sensitive than swine to ZEA exposure. Finally, results of in vivo animal studies and in vitro tests are reported and discussed.

Keywords: Zearalenone, Toxicity, Swine, Equus asinus, Granulosa Cells

Received: 01 Oct 2018; Accepted: 04 Dec 2018.

Edited by:

Joao B. Rocha, Universidade Federal de Santa Maria, Brazil

Reviewed by:

Lizelle Zandberg, North-West University, South Africa
Agnieszka W. Piastowska-Ciesielska, Medical University of Lodz, Poland
Karolina Gromadzka, Poznan University of Life Sciences, Poland
Isis M. Hueza, Universidade Federal de São Paulo, Diadema, Brazil  

Copyright: © 2018 Zhang, Feng, Song and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Jun-Lin Song, Qingdao Agricultural University, Qingdao, China, 1136319073@qq.com
Prof. Xiang-Shan Zhou, National Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong'e County, Shandong Province, China, Zhouxs@dongeejiao.com