Frontiers in Genetics

Original Research

Published on 17 Aug 2026

Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer

in Cancer Genetics and Oncogenomics

Guijun Li
Jinhong Bai
Sai Hu
Xiuli Gao
Fang Wang
Song Li

Frontiers in Genetics

doi 10.3389/fgene.2026.1861806

303 views

Review

Published on 17 Aug 2026

Integrating single-cell transcriptomics with deep learning for glioblastoma treatment

in Computational Genomics

Marybeth G. Yonk
Mainak Mustafi
Megan A. Lim
Kimberly B. Hoang
William H. Delaney
Charee M. Thompson
Thais Federici
Yuhong Du
Nicholas M. Boulis
Antonina Mitrofanova

Frontiers in Genetics

doi 10.3389/fgene.2026.1813369

232 views

Hypothesis and Theory

Accepted on 14 Aug 2026

A Methodological Framework for Real-World Performance Studies of Clinical Variant Classification Platforms at Early Organizational Stages

in Human and Medical Genomics

Vladimir Mitev

Frontiers in Genetics

129 views

Original Research

Accepted on 14 Aug 2026

Development and validation of a machine learning scoring system based on multi-dimensional metabolic signatures for invasive examination triage in intestinal diseases

in Cancer Genetics and Oncogenomics

Jintao He
Jiaorong Chen
Yingbo Rao
Yong Zhang
Mengning He
Mingli Zhu

Frontiers in Genetics

139 views

Review

Accepted on 14 Aug 2026

Plant Stress Memory: Epigenetic Mechanisms for Abiotic Stress Acclimation

in Genomics of Plants and Plant-Associated Organisms

APURBA PAL
AWADHESH KUMAR PAL
Rajendragouda Patil
Sudip Das
Ajay Bhardwaj
Anil Kumar Singh
Duniya Ram Singh

Frontiers in Genetics

137 views

Technology and Code

Published on 14 Aug 2026

FastqCA: an effective FASTQ compressor through 2D spatial redundancy reduction

in Statistical Genetics and Methodology

Shiyang Long
Qingting Wei
Yanni Zou
Yirui Zhou
Jie Lei
Jiaxu Li

Frontiers in Genetics

doi 10.3389/fgene.2026.1827471

391 views

Original Research

Published on 14 Aug 2026

Reclassification of the GRIA3 splice-site variant in an X-linked family with intellectual disability and psychiatric symptoms

in Genetics of Common and Rare Diseases

Lina Hu
Yuqiong Chai
Xiaofei Liu
Yanan Wang
Hongwei Jiang

Frontiers in Genetics

doi 10.3389/fgene.2026.1914453

434 views

Original Research

Published on 14 Aug 2026

Genetic analysis of Behçet’s disease using whole-exome sequencing and bioinformatics analysis in Korean patients

in Genetics of Common and Rare Diseases

Enkhjargal Bayarsaikhan
Hyunsoo Ahn
Sanguk Kim
Yong-Beom Park
Jae Hoon Lee

Frontiers in Genetics

doi 10.3389/fgene.2026.1787087

489 views

Brief Research Report

Accepted on 13 Aug 2026

Opportunities to Cultivate Trust through Communication Behaviors

in ELSI in Science and Genetics

Mary Carol Barks
Claire Yballa
Alexandra Linker
Chau Huynh
Gabrielle Cua
Malley Craig
Bridget Hein
Thomas May

Frontiers in Genetics

194 views

Original Research

Published on 13 Aug 2026

Sex-dependent prediction of autism

in Computational Genomics

Catriona J. Miller
Theo Portlock
Denis M. Nyaga
Justin M. O’Sullivan

Frontiers in Genetics

doi 10.3389/fgene.2026.1799530

461 views

Brief Research Report

Published on 13 Aug 2026

Rare missense variants in NECTIN1 alter local protein structure and may contribute to non-syndromic cleft lip with or without palate

in Genetics of Common and Rare Diseases

Ana Luiza Meneguci Moreira Franco
Deborah Antunes
Ana Carolina Proença da Fonseca
Ana Clara Rodrigues Moreira Gomes
Ana Carolina Ramos Guimarães
Ieda Maria Orioli
Flavia Martinez de Carvalho

Frontiers in Genetics

doi 10.3389/fgene.2026.1894075

414 views

Review

Published on 13 Aug 2026

Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures

in Cancer Genetics and Oncogenomics

Yiming Yang

Frontiers in Genetics

doi 10.3389/fgene.2026.1882506

277 views

Original Research

Published on 12 Aug 2026

Benchmarking of Oxford Nanopore whole genome sequencing for germline variant and CpG methylation detection across Canada’s national platform for genome sequencing and analysis

in Human and Medical Genomics

Jose Hector Galvez
Scott Mastromatteo
Kieran O’Neill
Robert Eveleigh
Haig Djambazian
Bhooma Thiruvahindrapuram
Eric Chuah
Shu-Huang Chen
Amirhossein Hajianpour
Zhuozhi Wang

Frontiers in Genetics

doi 10.3389/fgene.2026.1863034

866 views

Original Research

Published on 12 Aug 2026

PySimi: a unified framework for similarity measure evaluation in spectral clustering with applications to omics data

in Computational Genomics

Tianyi Shi
Xiucai Ye
Zeng Zou
Wenyu Xi
Tetsuya Sakurai

Frontiers in Genetics

doi 10.3389/fgene.2026.1913487

472 views

Original Research

Published on 12 Aug 2026

OtoVCE: a mechanism-aware language-model evidence layer for hereditary hearing-loss variant interpretation

in Computational Genomics

Shaopei Ye
Lan Wang
Peng Chen

Frontiers in Genetics

doi 10.3389/fgene.2026.1880490

438 views

Original Research

Published on 12 Aug 2026

SEPTIN9 R106W in a Chinese family with hereditary neuralgic amyotrophy: phenotypic heterogeneity and rehabilitation in a pediatric case

in Genetics of Common and Rare Diseases

Jing Chen
Shuang Chen
Xin-yi Zhu
Wei Su
Wen-Han Zhang
Dan Gao
Zhi-sheng Liu
Jing-jing Li
Hong-min Zhu

Frontiers in Genetics

doi 10.3389/fgene.2026.1909402

395 views

Original Research

Published on 12 Aug 2026

Machine learning-based identification of hub genes and prognostic biomarkers in prostate cancer

in Cancer Genetics and Oncogenomics

Guquan Chen
Jiefeng Zhang
Linfu Zhao
Jianyou Zhu

Frontiers in Genetics

doi 10.3389/fgene.2026.1877595

498 views

Original Research

Published on 12 Aug 2026

TPI1 promotes malignant progression and ferroptosis resistance in head and neck squamous cell carcinoma

in Human and Medical Genomics

Rui Ye
Zhihua Xu
Yehai Liu

Frontiers in Genetics

doi 10.3389/fgene.2026.1889940

506 views

Original Research

Published on 12 Aug 2026

A circulating three-miRNA panel (hsa-miR-29b-3p, hsa-miR-19b-3p, hsa-miR-30e-5p) for early-stage ovarian cancer detection: a machine-learning bioinformatics approach

in Cancer Genetics and Oncogenomics

Ahmed El Hosseiny
Meriem Yagoubi
Ahmed Moustafa
Asma Amleh

Frontiers in Genetics

doi 10.3389/fgene.2026.1827636

482 views

Original Research

Published on 12 Aug 2026

A reproducible epithelial transcriptional state combines interferon-associated and secretory programs in pancreatic ductal adenocarcinoma

in Cancer Genetics and Oncogenomics

Xingyu Mi
Shifan Wu
Liang Xiao

Frontiers in Genetics

doi 10.3389/fgene.2026.1907806

347 views

Original Research

Accepted on 10 Aug 2026

Mechanisms of Acquired Resistance to Osimertinib in EGFR T790M-Positive Lung Adenocarcinoma

in Human and Medical Genomics

Kefan Cui
Renjie Zhu
Jingmeng Li

Frontiers in Genetics

253 views

Original Research

Accepted on 10 Aug 2026

Dose-dependent gibberellic acid and benzylaminopurine priming coordinates transcriptional and metabolic reprogramming, enhancing photochemical efficiency to confer drought tolerance in pigeonpea

in Genomics of Plants and Plant-Associated Organisms

Rekha Rani
Shivam Kumar
Akhil Singh
Rachapudi V Sreeharsha

Frontiers in Genetics

229 views

Original Research

Accepted on 10 Aug 2026

Tumor-Immune Microenvironment and Nutritional Status Biomarkers Predict Recurrence and Immunotherapy Response After Total Colectomy for Locally Advanced Colon Cancer: Development and Validation of a Nomogram in a Retrospective Clinical Cohort

in Cancer Genetics and Oncogenomics

Yanhui Yang
Meng Gao
Songchun Liu
Qiong Yang

Frontiers in Genetics

231 views

Review

Accepted on 10 Aug 2026

Beyond Local Control: Radiotherapy–Immunotherapy Combinations From In Situ Vaccination to Systemic Immune Remodeling

in Cancer Genetics and Oncogenomics

Yulong Wen
Nannan Cheng
Sheng Zhou
Haixia Zhu
Qin Ge

Frontiers in Genetics

232 views

17,043 articles

articles

Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer

Integrating single-cell transcriptomics with deep learning for glioblastoma treatment

A Methodological Framework for Real-World Performance Studies of Clinical Variant Classification Platforms at Early Organizational Stages

Development and validation of a machine learning scoring system based on multi-dimensional metabolic signatures for invasive examination triage in intestinal diseases

Plant Stress Memory: Epigenetic Mechanisms for Abiotic Stress Acclimation

FastqCA: an effective FASTQ compressor through 2D spatial redundancy reduction

Reclassification of the GRIA3 splice-site variant in an X-linked family with intellectual disability and psychiatric symptoms

Genetic analysis of Behçet’s disease using whole-exome sequencing and bioinformatics analysis in Korean patients

Opportunities to Cultivate Trust through Communication Behaviors

Sex-dependent prediction of autism

Rare missense variants in NECTIN1 alter local protein structure and may contribute to non-syndromic cleft lip with or without palate

Advances in the association between tumor immune microenvironment remodeling in osteosarcoma and the risk of pathological fractures

Benchmarking of Oxford Nanopore whole genome sequencing for germline variant and CpG methylation detection across Canada’s national platform for genome sequencing and analysis

PySimi: a unified framework for similarity measure evaluation in spectral clustering with applications to omics data

OtoVCE: a mechanism-aware language-model evidence layer for hereditary hearing-loss variant interpretation

SEPTIN9 R106W in a Chinese family with hereditary neuralgic amyotrophy: phenotypic heterogeneity and rehabilitation in a pediatric case

Machine learning-based identification of hub genes and prognostic biomarkers in prostate cancer

TPI1 promotes malignant progression and ferroptosis resistance in head and neck squamous cell carcinoma

A circulating three-miRNA panel (hsa-miR-29b-3p, hsa-miR-19b-3p, hsa-miR-30e-5p) for early-stage ovarian cancer detection: a machine-learning bioinformatics approach

A reproducible epithelial transcriptional state combines interferon-associated and secretory programs in pancreatic ductal adenocarcinoma

Mechanisms of Acquired Resistance to Osimertinib in EGFR T790M-Positive Lung Adenocarcinoma

Dose-dependent gibberellic acid and benzylaminopurine priming coordinates transcriptional and metabolic reprogramming, enhancing photochemical efficiency to confer drought tolerance in pigeonpea

Tumor-Immune Microenvironment and Nutritional Status Biomarkers Predict Recurrence and Immunotherapy Response After Total Colectomy for Locally Advanced Colon Cancer: Development and Validation of a Nomogram in a Retrospective Clinical Cohort

Beyond Local Control: Radiotherapy–Immunotherapy Combinations From In Situ Vaccination to Systemic Immune Remodeling