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Front. Genet. | doi: 10.3389/fgene.2019.00395

Combining understanding of immunological mechanisms and genetic variants towards development of personalized medicine for psoriasis patients

  • 1School of Biosciences, Taylor's University, Malaysia

Psoriasis is multifactorial disease with complex genetic predisposition. Recent advances in genetics and genomics analyses have provided many insights into the relationship between specific genetic predisposition and the immunopathological mechanisms driving psoriasis manifestation. Novel approaches which utilize array-based genotyping technologies such as genome-wide association studies and bioinformatics tools for transcriptomics analysis have identified single nucleotide polymorphisms, genes and pathways that are associated with psoriasis. The discovery of these psoriasis-associated susceptibility loci, autoimmune targets and altered signaling pathways have provided opportunities to bridge the gap of knowledge from sequence to consequence, allowing new therapeutic strategies for the treatment of psoriasis to be developed. Here, we discuss recent advances in the field by highlighting how immune functions associated with psoriasis susceptibility loci may contribute to disease pathogenesis in different populations. Understanding the genetic variations in psoriasis and how these may influence the immunological pathways to cause disease will contribute to the efforts in developing novel and targeted personalized therapies for psoriasis patients.

Keywords: Psoriasis, Susceptibility loci, Genome-wide association studies (GWAS), personalized medicine, Autoimmune disorder

Received: 02 Dec 2018; Accepted: 11 Apr 2019.

Edited by:

Fusheng Zhou, Anhui Medical University, China

Reviewed by:

Fengyu Zhang, Global Clinical and Translational Research Institute, United States
Changbing Shen, China-Japan Friendship Hospital, China  

Copyright: © 2019 Gunter, Yap, Chua and Yap. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Dr. Caroline L. Chua, School of Biosciences, Taylor's University, Subang Jaya, 47500, Selangor Darul Ehsan, Malaysia,
Dr. Wei Hsum Yap, School of Biosciences, Taylor's University, Subang Jaya, 47500, Selangor Darul Ehsan, Malaysia,