Original Research ARTICLE
Positive psychotic symptoms associated with a schizophrenia risk variant in TCF4 in the Southern Chinese Han population
- 1Department of Neurology, Affiliated Hospital of Guangdong Medical University, China
- 2Affiliated Hospital of Guangdong Medical University, China
- 3Department of Neurology, The First Affiliated Hospital, Jinan University, China
- 4Jinan University, China
- 5Clinical Research Center, Affiliated Hospital of Guangdong Medical University, China
- 6Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, China
- 7Experiment Animal Center, Guangdong Medical University, China
Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a candidate risk gene in the development of the central nervous system, transcription factor 4 (TCF4) has been shown to be involved in the pathogenesis of schizophrenia. The aim of our study was to assay the association of TCF4 single nucleotide polymorphisms (SNPs) with schizophrenia and the effect of these SNPs on phenotypic variability in schizophrenia.
Method: Four SNPs (rs9960767, rs2958182, rs4309482, and rs12966547) of TCF4 were genotyped in 1137 schizophrenic patients and 1035 controls in a Southern Chinese Han population using the improved multiplex ligation detection reaction (iMLDR) technique. For patients with schizophrenia, the severity of symptom phenotypes was analysed by the five-factor model of the Positive and Negative Symptom Scale (PANSS). Cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS) scale.
Results: The results showed that the genotypes and alleles of the 4 SNPs were not significantly different between the control group and the case group (all P > 0.05). However, the genotypes of rs4309482 (P=0.04) and rs12966547 (P=0.03) were related to the positive symptoms of the PANSS. In addition, the genotypes of rs4309482 had a significant difference for excitement scores (P=0.04).
Conclusion: TCF4 might be a risk factor affecting schizophrenia in a phenotype-specific manner in the Southern Chinese Han population.
Keywords: Schizophrenia, TCF4, polymorphisms, Positive psychotic symptoms, Southern Chinese Han population
Received: 05 Nov 2018;
Accepted: 10 May 2019.
Edited by:Zhexing Wen, Emory University School of Medicine, United States
Reviewed by:Fabian Streit, Central Institute for Mental Health, Germany
Gabriel R. Fries, University of Texas Health Science Center at Houston, United States
Copyright: © 2019 Ma, Li, Wang, Yin, Zhu, Li, Lv, Yu, Liang, Luo, Xu, Fu, Yan, Dai, Zhou, Wen, Xiong, Lin, Lin and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Prof. Guoda Ma, Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China, firstname.lastname@example.org
Prof. Keshen Li, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China, email@example.com
Prof. Yajun Wang, Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China, firstname.lastname@example.org