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Front. Genet. | doi: 10.3389/fgene.2019.00682

Chromatin Remodeling Complex NuRD in Neurodevelopment and Neurodevelopmental Disorders

  • 1Max Planck Institute of Psychiatry (MPI), Germany

The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major chromatin remodeling complexes in mammalian cells. Here we discuss current evidence for NuRD’s role as an important epigenetic regulator of gene expression in neural stem cell (NSC) and neural progenitor cell (NPC) fate decisions in brain development. With the formation of the cerebellar and cerebral cortex, NuRD facilitates experience-dependent cerebellar plasticity and regulates additionally cerebral subtype specification and connectivity in postmitotic neurons. Consistent with these properties, genetic variation in NuRD’s subunits emerges as important risk factor in common polygenic forms of neurodevelopmental disorders (NDDs) and neurodevelopment-related psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BD). Overall, these findings highlight the critical role of NuRD in chromatin regulation in brain development, and in mental health and disease.

Keywords: NuRD, NSC, NPC, neurodevelopement, corticogenesis, NDD, Schizophrenia, Bipolar Disorder

Received: 13 May 2019; Accepted: 01 Jul 2019.

Edited by:

Hehuang Xie, Virginia Tech, United States

Reviewed by:

Vincent Tropepe, University of Toronto, Canada
Richard A. Katz, Fox Chase Cancer Center, United States  

Copyright: © 2019 Spengler and Hoffmann. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Dietmar Spengler, Max Planck Institute of Psychiatry (MPI), Munich, 80804, Bavaria, Germany, spengler@mpipsykl.mpg.de