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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Genet. | doi: 10.3389/fgene.2019.00851

Consensus expressed CXCL8 and MMP9 identified by meta-analyzed perineural invasion gene signature in gastric cancer microarray data

 Xiuzhi Jia1, 2, Minjia Lu2,  Chen Rui2 and Ying Xiao2*
  • 1Sir Run Run Shaw Hospital, China
  • 2Biomedical Research Center, Sir Run Run Shaw Hospital, China

As an under-recognized route of cancer metastasis, perineural invasion (PNI) can be defined as the procedure of neoplastic invasion of nerves, which can be targeted to inhibit the metastasis of malignant cancer. However, the underline mechanism of PNI in cancer is still unknown. We constructed a PNI gene signature based on Pathway Studio mediated literature screen and sought to investigate these genes in a gastric cancer model. Thus, a total of 467 studies/datasets were retrieved in Gene Expression Omnibus database (GEO) using the keywords “gastric cancer”, among which 13 studies focused on gene expression profiling were further manually inspected and selected. Furthermore, the constructed PNI gene signature (104 genes) expression was meta-analyzed, and consensus expressed C-X-C Motif Chemokine Ligand 8 (CXCL8) and matrix Metallopeptidase 9 (MMP9) (p<0.01, |LFC|>1) were detected. Importantly, the disease-free survival was significantly worse in patients with high expression of CXCL8 and MMP9 than that in patients with low expression of CXCL8 and MMP9 (P = 0.05). Moreover, the multiple linear regression (MLR) analysis showed that the population region (country) was associated with the expression of both CXCL8 and MMP9. In conclusion, these data suggested that the co-expressed CXCL8 and MMP9 could be early detection marker for PNI, with a potential to be utilized as individual or racial therapy target for early treatment to prevent PNI related cancer metastasis.

Keywords: gastric cancer, Meta-analysis, CXCL8, MMP9, Perineural invasion

Received: 05 Jun 2019; Accepted: 15 Aug 2019.

Copyright: © 2019 Jia, Lu, Rui and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ying Xiao, Biomedical Research Center, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, China,