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REVIEW article

Front. Genet.
Sec. Epigenomics and Epigenetics
Volume 15 - 2024 | doi: 10.3389/fgene.2024.1380746
This article is part of the Research Topic Epigenetic Regulation of Genome Integrity and its Implications in Human Diseases View all 4 articles

The functions and mechanisms of RNA modification in prostate: Current status and future perspectives

Provisionally accepted

The final, formatted version of the article will be published soon.

    The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression for effective prevention and treatment. RNA modification, an important post-transcriptional regulatory process, profoundly influences tumor cell growth and metabolism, shaping cell fate.Over 170 RNA modification methods are known, with prominent research focusing on N6-methyladenosine, N7-methylguanosine, N1-methyladenosine, 5-methylcytidine, pseudouridine, and N4-acetylcytidine modifications. These alterations intricately regulate coding and non-coding RNA post-transcriptionally, affecting the stability of RNA and protein expression levels. This article delves into the latest advancements and challenges associated with various RNA modifications in prostate cancer tumor cells, tumor microenvironment, and core signaling molecule androgen receptors. It aims to provide new research targets and avenues for molecular diagnosis, treatment strategies, and improvement of the prognosis in prostate cancer.

    Keywords: RNA modification, prostate cancer, AR, Tumor Microenvironment, crpc

    Received: 02 Feb 2024; Accepted: 11 Apr 2024.

    Copyright: © 2024 Zhang, Liu, Wu, Zhuoran, Zou, Liu, Geng, Mao, Luo, Guo, Zhang and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xudong Yao, Tongji University, Shanghai, 200092, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.