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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Neuroanat. | doi: 10.3389/fnana.2018.00098

Three-dimensional probabilistic maps of mesial temporal lobe structures in children and adolescents’ brains.

 Antoine Bouyeure1,  David Germanaud1, 2, Dhaif Bekha1, Victor Delattre1,  Julien Lefèvre3, Charlotte Pinabiaux4,  Jean-Francois Mangin5, Denis Rivière5, Clara Fischer5,  Catherine CHIRON1,  Lucie Hertz-Pannier1 and  Marion Noulhiane1*
  • 1INSERM U1129 Epilepsies de l'enfant et Plasticité Cérébrale, France
  • 2Service de Neurologie Pédiatrique et Maladies Métaboliques, Hôpital Robert Debré, France
  • 3UMR7296 Laboratoire des Sciences de l'Information et des Systèmes (LSIS), France
  • 4EA4004 Laboratoire Cognitions Humaine et Artificielle, France
  • 5UNATI, Neurospin, France

The hippocampus and the adjacent perirhinal, entorhinal, temporopolar and parahippocampal cortices are interconnected in a hierarchical MTL system crucial for memory processes. A probabilistic description of the anatomical location and spatial variability of MTL cortices in the child and adolescent brain would help to assess structure-function relationships. The rhinal sulcus (RS) and the collateral sulcus (CS) that border MTL cortices and influence their morphology have never been described in these populations. In this study, we identified the aforementioned structures on magnetic resonance images of 38 healthy subjects aged 7-17 years old. Relative to sulcal morphometry in the MTL, we showed RS-CS conformation is an additional factor of variability in the MTL that is not explained by other variables such as age, sex and brain volume; with an innovative method using permutation testing of the extrema of structures of interest, we showed that RS-SC conformation was not associated with differences of location of MTL sulci. Relative to probabilistic maps, we offered for the first time a systematic mapping of MTL structures in children and adolescent, mapping all the structures of the MTL system while taking sulcal morphology into account. Our results, with the probabilistic maps described here being freely available for download, will help to understand the anatomy of this region and help functional and clinical studies to accurately test structure-function hypotheses in the MTL during development.

Keywords: medial temporal lobe, probabilistic map, Brain developement, Hippocampus, Parahippocampal Gyrus

Received: 18 Jul 2018; Accepted: 29 Oct 2018.

Edited by:

Ricardo Insausti, University of Castilla La Mancha, Spain

Reviewed by:

Thomas Z. Ramsøy, Neurons Inc, Denmark
Pierre-Louis Bazin, University of Amsterdam, Netherlands  

Copyright: © 2018 Bouyeure, Germanaud, Bekha, Delattre, Lefèvre, Pinabiaux, Mangin, Rivière, Fischer, CHIRON, Hertz-Pannier and Noulhiane. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Marion Noulhiane, INSERM U1129 Epilepsies de l'enfant et Plasticité Cérébrale, Paris, 75015, Île-de-France, France, marion.noulhiane@parisdescartes.fr