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Front. Neuroanat. | doi: 10.3389/fnana.2019.00034

A Reevaluation of the Anatomy of the Claustrum in Rodents and Primates – Analysing the Effect of Pallial Expansion

  • 1University of Western Australia, Australia
  • 2Perron Institute for Neurological and Translational Science, Australia
  • 3Neuroscience Research Australia (NeuRA), Australia
  • 4University of Murcia, Spain

The components of the claustrum have been identified by gene expression in mice, but there is still uncertainty about the location of homologous components in primates. To aid interpretation of homologous elements between rodents and primates, we used a current understanding of pallial topology, species specific telencephalic deformation, and gene expression data. In both rodents and primates, pallial areas maintain conserved topological relationships regardless of relative differences in pallial expansion. The components of the claustrum in primates can therefore be identified on the basis of their conserved topological relationships and patterns of gene expression. In rodents, a fairly straight telencephalic long axis runs between the early septopreoptic and amygdalar poles of the pallium. In primates however, the remarkable dorsal pallial expansion causes this axis to be distorted to form a C shape. This has resulted in a number of errors in the interpretation of the location of claustral components. These errors are likely to have resulted from the unexpected topographical positioning of claustral components due to the bent telencephalic axis. We argue that, once the telencephalic distortion has been accounted for, both rodents and primates have homologous claustral components, and that the topological relationships of these components are conserved regardless of differences in the relative expansion of pallial areas.

Keywords: claustrum, dorsal endopiriform nucleus, macaque, rodent, organisation

Received: 22 Nov 2018; Accepted: 06 Mar 2019.

Edited by:

David Reser, Monash University, Australia

Reviewed by:

Marina Bentivoglio, University of Verona, Italy
Nina Patzke, Hokkaido University, Japan  

Copyright: © 2019 Binks, Watson and Puelles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Charles R. Watson, University of Western Australia, Perth, 6009, Western Australia, Australia, c.watson@curtin.edu.au