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REVIEW article

Front. Nephrol.
Sec. Glomerular disease
Volume 4 - 2024 | doi: 10.3389/fneph.2024.1390783
This article is part of the Research Topic Insights in Glomerular Disease View all 3 articles

Lupus Nephritis: Management Challenges During Pregnancy

Provisionally accepted
Zohreh Gholizadeh Ghozloujeh Zohreh Gholizadeh Ghozloujeh 1*Tripti Singh Tripti Singh 2Kenar Jhaveri Kenar Jhaveri 3Silvi Shah Silvi Shah 4Edgar Lerma Edgar Lerma 5Amir Abdipour Amir Abdipour 1Sayna Norouzi Sayna Norouzi 1*
  • 1 Loma Linda University, Loma Linda, California, United States
  • 2 University of Wisconsin-Madison, Madison, Wisconsin, United States
  • 3 Donald and Barbara Zucker School of Medicine, Hofstra University, Hempstead, New York, United States
  • 4 College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States
  • 5 College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States

The final, formatted version of the article will be published soon.

    Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), leads to significant kidney inflammation and damage and drastically increases mortality risk. Predominantly impacting women in their reproductive years, LN poses specific risks during pregnancy, including pre-eclampsia, growth restrictions, stillbirth, and preterm delivery, exacerbated by lupus activity, specific antibodies, and pre-existing conditions like hypertension. Effective management of LN during pregnancy is crucial and involves carefully balancing disease control with the safety of the fetus. This includes pre-conception counseling and a multidisciplinary approach among specialists to navigate the complexities LN patients face during pregnancy, such as distinguishing LN flare-ups from pregnancy-induced conditions. This review focuses on exploring the complex dynamics between pregnancy and LN, emphasizing the management difficulties and the heightened risks pregnant women with LN encounter.

    Keywords: Lupus Nephritis, Pregnancy, management of pregnancy, pre-conception counseling, multidisciplinary management

    Received: 23 Feb 2024; Accepted: 15 May 2024.

    Copyright: © 2024 Gholizadeh Ghozloujeh, Singh, Jhaveri, Shah, Lerma, Abdipour and Norouzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zohreh Gholizadeh Ghozloujeh, Loma Linda University, Loma Linda, 92350, California, United States
    Sayna Norouzi, Loma Linda University, Loma Linda, 92350, California, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.