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Front. Hum. Neurosci. | doi: 10.3389/fnhum.2019.00334

Relationship between integrity of the corpus callosum and bimanual coordination in children with Unilateral Spastic Cerebral Palsy

 Ya Ching Hung1*, Maxime Robert2, 3,  Kathleen Friel3 and  Andrew Gordon2
  • 1Queens College (CUNY), United States
  • 2Department of Biobehavioral Sciences, Teachers College, Columbia University, United States
  • 3Burke Neurological Institute (BNI), United States

Children with unilateral spastic cerebral palsy (USCP) have shown impaired bimanual coordination. The corpus callosum (CC) connects the two hemispheres and is critical for tasks that require inter-hemisphere communication. The relationship between the functional bimanual coordination impairments and structural integrity of the CC is unclear. We hypothesized that better integrity of the CC would relate to better bimanual coordination performance during a kinematic bimanual drawer-opening task. Thirty-nine children with USCP (Age: 6-17 years old; MACS levels: I-III) participated in the study. Measurement of the CC integrity was performed using diffusion tensor imaging. The CC was measured as a whole and was also divided into three regions: genu, midbody, and splenium. Fractional anisotropy, axial diffusivity (AD), radial diffusivity, mean diffusivity, number of voxels, and number of streamlines were evaluated in whole and within each region of the CC. 3-D kinematic analyses of bimanual coordination were also assessed while children performed the bimanual task.
There were negative correlations between bimanual coordination measures of total movement time and AD of whole CC (p=0.037), number of streamlines and voxels of splenium (p=0.038, 0.032 respectively); goal synchronization and AD of whole CC (p=0.04), number of streamlines and voxels of splenium (p=0.001, 0.01 respectively). The current results highlight the possible connection between the integrity of the CC, especially between the splenium region and temporal bimanual coordination performance for children with USCP.

Keywords: Corpus Callosum, pediatric, diffusion MRI, Kinematic, Upper extremities, Cerebral Palsy

Received: 20 Jun 2019; Accepted: 10 Sep 2019.

Copyright: © 2019 Hung, Robert, Friel and Gordon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Mx. Ya Ching Hung, Queens College (CUNY), New York City, United States, yaching.hung@qc.cuny.edu