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Editorial ARTICLE

Front. Integr. Neurosci., 27 November 2018 | https://doi.org/10.3389/fnint.2018.00058

Editorial: Modulating Cortical Dynamics in Language, Speech and Music

Gesa Hartwigsen1*, Mathias Scharinger2 and Daniela Sammler3
  • 1Research Group Modulation of Language Networks, Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
  • 2Phonetics Research Group, Department of German Linguistics, Center for Mind, Brain and Behavior, Philipps-Universität Marburg, Marburg, Germany
  • 3Otto Hahn Group “Neural Bases of Intonation in Speech and Music”, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Language, speech and music are uniquely human channels of communication resting on evolved neurocognitive circuits. Research on the neurobiological foundations of these abilities has taken considerable strides across the past 25 years. Accordingly, current large-scale models provide fine-grained maps of specialized fronto-temporo-parietal networks that support complementary computational goals. Dorsal and ventral stream models for speech and language (Hickok and Poeppel, 2007; Rauschecker and Scott, 2009; Friederici, 2011; Bornkessel-Schlesewsky and Schlesewsky, 2013), vocal pitch (Sammler et al., 2015), and music (Loui, 2015; Peretz, 2016), and sensorimotor control models of speech (Guenther and Hickok, 2015; Houde and Chang, 2015) and song (Berkowska and Dalla Bella, 2009; Zarate, 2013) are just a few examples.

Based on these models, new questions on the functional dynamics within and across these large-scale networks arise. For instance, it remains largely unclear how key regions operate and communicate with each other, from lower (sensory) to higher (cognitive) levels. Another central question concerns the functional relevance of these regions to specific processes and their differential contribution across individuals. Recently, macro-anatomical lesion studies and correlative neuroimaging approaches have been complemented by non-invasive brain stimulation (NIBS) methods that promise answers to these questions. Through focal modulation of neural activity, they provide a means to directly probe the causal contribution of circumscribed cortical regions to a given task (Pascual-Leone et al., 1999; Walsh and Cowey, 2000; Kuo and Nitsche, 2012) and allow for an investigation of adaptive network dynamics on the systems level (Hartwigsen, 2018).

This Research Topic comprises a collection of one review and five original research papers that applied state-of-the-art transcranial magnetic stimulation (TMS) and transcranial direct-current stimulation (tDCS) to increase our understanding of the cortical dynamics within and between the large-scale neural networks underlying language, speech, and music in the healthy brain. Together, they reveal the dynamic exchange between hemispheres (Andoh et al. ; Hohmann et al. ), the temporal dynamics within brain regions (Zhang et al. ), as well as the specific division of labor within networks (Ishibashi et al. ). Moreover, they show individual differences in network dynamics (Andoh et al. ) with potential consequences for behavior and neuromodulatory effects of NIBS (Deroche et al. ; Schaal et al. ).

Starting at the level of auditory cortex, Andoh et al. provide a comprehensive review of NIBS studies that shed light on local and remote interactions in auditory areas contributing to speech and music perception. Specifically, this review highlights functional differences of left and right auditory cortex and argues for strong, yet asymmetric interhemispheric interactions between auditory regions that largely depend on individual connectivity patterns. Providing a translational link, the authors also discuss the therapeutic potential of NIBS in the treatment of auditory neurological disorders such as tinnitus.

Moving from auditory perception to production, three studies used tDCS and TMS to investigate causal contributions of dorsal stream regions in the production of speech or vocal pitch. Focusing on speech motor learning, Deroche et al. applied tDCS to left inferior parietal lobe (IPL) to modulate motor adaptation to altered auditory feedback. Participants exhibited increased adaptation under facilitatory (anodal) tDCS, showing that tDCS of left IPL can enhance speech motor learning. No effects of anodal tDCS were found in conditions with unaltered feedback, arguing for a specific role of left IPL in learning, but not regular speech motor control. This is in line with the notion of a strong context-dependency of NIBS effects (Silvanto and Cattaneo, 2017). Focusing on vocal pitch production, Hohmann et al. found decreased performance in targeting and fine-tuning vocal pitch in a humming task after inhibition of right posterior superior temporal gyrus (STG) and left posterior inferior frontal gyrus (IFG) by means of cathodal tDCS. They propose specific roles of these areas in feedback and feed-forward motor control of pitched vocal production. These results provide additional support for the relevance of interhemispheric interactions (see also Andoh et al. ). Zhang et al. further zoomed into the temporal dynamics of left IFG involvement in speech production using chronometric TMS. They applied triple pulse TMS at different time points during picture naming in Mandarin Chinese speakers, and found strongest delays in response times when TMS was applied as early as 225 ms after picture onset. These results are taken to suggest that phonological encoding in Mandarin Chinese occurs a little earlier than in Indo-European languages (Indefrey and Levelt, 2004), highlighting language-dependent inter-individual differences.

Finally, two studies used tDCS and TMS to elucidate higher-level cognitive functions in language and music. Ishibashi et al. dissociated the specific roles of left anterior temporal lobe (ATL) and IPL in semantic cognition. Anodal tDCS of the left ATL improved access to knowledge about both function and manipulation of common tools, while stimulation of IPL had selective effects on function knowledge only, supporting the hub-and-spokes model of semantic representations (Ralph et al., 2017). In turn, Schaal et al. show causal involvement of right dorsolateral prefrontal cortex in pitch memory and highlight the dependency of NIBS effects on individual baseline abilities. Accordingly, cathodal tDCS selectively impaired performance of non-musicians in a pitch span task, but only if they had a high baseline pitch memory. These results stress inter-individual variability in response to neuromodulatory effects of NIBS protocols (Hamada et al., 2013) that may emerge from different network configurations and dynamics between individuals.

Together, these studies emphasize the value of NIBS to investigate causal structure-function relationships, and modulate cognitive dynamics in the language, speech and music domains. These findings pave the way for future applications in basic research and therapeutic settings. The way forward will include multi-method combinations of NIBS and electrophysiological or neuroimaging techniques to provide a comprehensive characterization of the functional relevance and interaction of specific regions within and between the neural networks for language, speech, and music, as well as their individual dynamics and differences.

Author Contributions

All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

Berkowska, M., and Dalla Bella, S. (2009). Acquired and congenital disorders of sung performance: a review. Adv. Cogn. Psychol. 5, 69–83. doi: 10.2478/v10053-008-0068-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Bornkessel-Schlesewsky, I., and Schlesewsky, M. (2013). Reconciling time, space and function: a new dorsal-ventral stream model of sentence comprehension. Brain Lang. 125, 60–76. doi: 10.1016/j.bandl.2013.01.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Friederici, A. D. (2011). The brain basis of language processing: from structure to function. Physiol. Rev. 91, 1357–1392. doi: 10.1152/physrev.00006.2011

PubMed Abstract | CrossRef Full Text | Google Scholar

Guenther, F. H., and Hickok, G. (2015). Role of the auditory system in speech production. Handb. Clin. Neurol. 129, 161–175. doi: 10.1016/B978-0-444-62630-1.00009-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Hamada, M., Murase, N., Hasan, A., Balaratnam, M., and Rothwell, J. C. (2013). The role of interneuron networks in driving human motor cortical plasticity. Cereb. Cortex 23, 1593–1605. doi: 10.1093/cercor/bhs147

PubMed Abstract | CrossRef Full Text | Google Scholar

Hartwigsen, G. (2018). Flexible redistribution in cognitive networks. Trends Cogn. Sci. 22, 687–698. doi: 10.1016/j.tics.2018.05.008

PubMed Abstract | CrossRef Full Text | Google Scholar

Hickok, G., and Poeppel, D. (2007). The cortical organization of speech processing. Nat. Rev. Neurosci. 8, 393–402. doi: 10.1038/nrn2113

PubMed Abstract | CrossRef Full Text | Google Scholar

Houde, J. F., and Chang, E. F. (2015). The cortical computations underlying feedback control in vocal production. Curr. Opin. Neurobiol. 33, 174–181. doi: 10.1016/j.conb.2015.04.006

PubMed Abstract | CrossRef Full Text | Google Scholar

Indefrey, P., and Levelt, W. J. (2004). The spatial and temporal signatures of word production components. Cognition 92, 101–144. doi: 10.1016/j.cognition.2002.06.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Kuo, M. F., and Nitsche, M. A. (2012). Effects of transcranial electrical stimulation on cognition. Clin. EEG Neurosci. 43, 192–199. doi: 10.1177/1550059412444975

PubMed Abstract | CrossRef Full Text | Google Scholar

Loui, P. (2015). A Dual-Stream Neuroanatomy of Singing. Music Percept. 32, 232–241. doi: 10.1525/mp.2015.32.3.232

PubMed Abstract | CrossRef Full Text | Google Scholar

Pascual-Leone, A., Bartres-Faz, D., and Keenan, J. P. (1999). Transcranial magnetic stimulation: studying the brain-behaviour relationship by induction of 'virtual lesions'. Philos. Trans. R. Soc. Lond. B Biol. Sci. 354, 1229–1238. doi: 10.1098/rstb.1999.0476

PubMed Abstract | CrossRef Full Text | Google Scholar

Peretz, I. (2016). Neurobiology of congenital amusia. Trends Cogn. Sci. 20, 857–867. doi: 10.1016/j.tics.2016.09.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Ralph, M. A., Jefferies, E., Patterson, K., and Rogers, T. T. (2017). The neural and computational bases of semantic cognition. Nat. Rev. Neurosci. 18, 42–55. doi: 10.1038/nrn.2016.150

PubMed Abstract | CrossRef Full Text | Google Scholar

Rauschecker, J. P., and Scott, S. K. (2009). Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing. Nat. Neurosci. 12, 718–724. doi: 10.1038/nn.2331

PubMed Abstract | CrossRef Full Text | Google Scholar

Sammler, D., Grosbras, M. H., Anwander, A., Bestelmeyer, P. E., and Belin, P. (2015). Dorsal and ventral pathways for prosody. Curr. Biol. 25, 3079–3085. doi: 10.1016/j.cub.2015.10.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Silvanto, J., and Cattaneo, Z. (2017). Common framework for “virtual lesion” and state-dependent TMS: the facilitatory/suppressive range model of online TMS effects on behavior. Brain Cogn. 119, 32–38. doi: 10.1016/j.bandc.2017.09.007

PubMed Abstract | CrossRef Full Text | Google Scholar

Walsh, V., and Cowey, A. (2000). Transcranial magnetic stimulation and cognitive neuroscience. Nat. Rev. Neurosci. 1, 73–79. doi: 10.1038/35036239

PubMed Abstract | CrossRef Full Text | Google Scholar

Zarate, J. M. (2013). The neural control of singing. Front. Hum. Neurosci. 7:237. doi: 10.3389/fnhum.2013.00237

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: non-invasive brain stimulation (NIBS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation, network, virtual lesion, cognition

Citation: Hartwigsen G, Scharinger M and Sammler D (2018) Editorial: Modulating Cortical Dynamics in Language, Speech and Music. Front. Integr. Neurosci. 12:58. doi: 10.3389/fnint.2018.00058

Received: 01 October 2018; Accepted: 06 November 2018;
Published: 27 November 2018.

Edited and reviewed by: Jochen Kaiser, Goethe-Universität Frankfurt am Main, Germany

Copyright © 2018 Hartwigsen, Scharinger and Sammler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Gesa Hartwigsen, hartwigsen@cbs.mpg.de