Impact Factor 4.134

The 2nd most cited  journal in Physiology

General Commentary ARTICLE

Front. Physiol., 30 October 2017 | https://doi.org/10.3389/fphys.2017.00838

Commentary: Managing Thoracic Aortic Aneurysm in Patients with Bicuspid Aortic Valve Based on Aortic Root-Involvement

Marco Russo*, Paolo Nardi, Guglielmo Saitto, Fabio Bertoldo and Giovanni Ruvolo
  • Department of Cardiac Surgery, Tor Vergata University of Rome, Rome, Italy

We read with great interest the paper from Norton and Yang (2017) in which they optimally described their philosophy in the treatment of patients affected by concomitant bicuspid aortic valve and thoracic aorta dilation. They described an interesting tailored approach based on the involvement of aortic root: an aggressive surgical resection for diameter larger than 50 mm is proposed in case of root dilation associated with aortic insufficiency (Cluster A; malignant form) whereas a less precocious aortic resection (diameter > 55 mm) for “cluster B” patients, defined as no root dilation but with ascending aorta enlargement (benign form).

Patients affected by bicuspid aortic valve aortophaty represent a heterogeneous population in which both genetics and hemodynamic factors play a special role in the pathogenesis of proximal aorta dilation (Veldtman et al., 2006; Michelena et al., 2008; Della Corte et al., 2014).

In this brief commentary we would like to focus on a particular subgroup of patients, that we would like to define as “modified Cluster B”: in this population the dilation of ascending aorta represents the indication for operation in presence of a normally functioning bicuspid aortic valve and not dilated root. These patients represent a very rare cohort in which the cardiac surgeon should manage the possibility to preserve a not-malfunctioning but congenitally altered valve and with not enlarged bicuspid Sinues of Valsalva.

In our recently published data (Russo et al., 2017) on 47 patients (mean age 57 ± 11 years, 31 males) treated in a 20-years period, we reported a very low risk of reoperation on spared aortic root with an actuarial freedom reoperation of 100 and 94.4 ± 5.6% at 5 and 10 years. No significantly enlargement of Sinuses was recorded in echo assessment and no new acute aortic syndromes occurred. Moreover, the requirement for a reoperation during the follow-up period was determined by leaflet pathology in presence of still normal root. We assessed that, even in the setting of a bicuspid aortic root, the treatment of a cluster B patient with normally functioning valve and not enlarged Sinues is a safe and valuable option (Russo et al., 2017). Moreover we observed that this particular aortic dilation phenotype is associated with type 0 BAV with antero-posterior orientation. Maybe this association described a particular subcategory with a genetic substrate not yet completely understood.

What we would like to know is the Author's experience when faced with a similar situation of “modified Cluster B” patients.

What could we learn more in the field of bicuspid aortic valve syndrome?

Author Contributions

MR is the main investigator. PN was responsible of data analysis. GS participated to data collection of follow up. FB was responsible of data collection. GR was coordinator.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

Della Corte, A., Body, S. C., Booher, A. M., Schaefers, H. J., Milewski, R. K., Michelena, H., et al. (2014). Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives. J. Thorac. Cardiovasc. Surg. 147, 1749–1757. doi: 10.1016/j.jtcvs.2014.01.021

PubMed Abstract | CrossRef Full Text | Google Scholar

Michelena, H. I., Desjardins, V. A., Avierinos, J. F., Russo, A., Nkomo, V. T., Sundt, T. M., et al. (2008). Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation 117, 2776–2784. doi: 10.1161/CIRCULATIONAHA.107.740878

PubMed Abstract | CrossRef Full Text | Google Scholar

Norton, E., and Yang, B. (2017). Managing thoracic aortic aneurysm in patients with bicuspid aortic valve based on aortic root-involvement. Front. Physiol. 13:397. doi: 10.3389/fphys.2017.00397

PubMed Abstract | CrossRef Full Text | Google Scholar

Russo, M., Saitto, G., Nardi, P., Bertoldo, F., Scafuri, A., Bassano, C., et al. (2017). Bicuspid aortic root spared during ascending aorta surgery: anupdate of long-term results. J. Thorac. Dis. 9, 1634–1638. doi: 10.21037/jtd.2017.05.83

PubMed Abstract | CrossRef Full Text | Google Scholar

Veldtman, G. R., Connolly, H. M., Orszulak, T. A., Dearani, J. A., and Schaff, H. V. (2006). Fate of bicuspid aortic valves in patients undergoing aortic root repair or replacement for aortic root enlargement. Mayo Clin. Proc. 81, 322–326. doi: 10.4065/81.3.322

CrossRef Full Text | Google Scholar

Keywords: bicuspid valve, ascending aorta, aortic root, valve sparing, genetic syndromes

Citation: Russo M, Nardi P, Saitto G, Bertoldo F and Ruvolo G (2017) Commentary: Managing Thoracic Aortic Aneurysm in Patients with Bicuspid Aortic Valve Based on Aortic Root-Involvement. Front. Physiol. 8:838. doi: 10.3389/fphys.2017.00838

Received: 09 August 2017; Accepted: 09 October 2017;
Published: 30 October 2017.

Edited by:

Zhongkui Hong, University of South Dakota, United States

Reviewed by:

Hanrui Zhang, Columbia University, United States

Copyright © 2017 Russo, Nardi, Saitto, Bertoldo and Ruvolo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Marco Russo, mar.russo1987@gmail.com