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ORIGINAL RESEARCH article

Front. Physiol.
Sec. Metabolic Physiology
Volume 15 - 2024 | doi: 10.3389/fphys.2024.1358177
This article is part of the Research Topic Strategies to Overcome Metabolic Syndrome and Related Diseases View all 9 articles

Impact of co-administration of apricot kernels and caffeine on adult male diabetic albino rats

Provisionally accepted
Ahmed E. Nour El-Deen Ahmed E. Nour El-Deen 1,2*Ahmad M. Taha Ahmad M. Taha 3,4Almoatazbellah Elsayed Almoatazbellah Elsayed 5,6*Ahmed N. Ali Ahmed N. Ali 5,7*Reda S. Taha Reda S. Taha 5,8*
  • 1 Department of basic medical and dental sciences, Faculty of Dentistry,, Zarqa University, Zarqa, Zarqa, Jordan
  • 2 Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Assuit, Egypt
  • 3 Department of basic medical and dental sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan., Zarqa, Jordan
  • 4 Department of physiology, Faculty of Medicine, Port Said University, Port Said, Port Said, Egypt
  • 5 Department of basic medical and dental sciences, Faculty of Dentistry, Zarqa University, Zarqa, Zarqa, Jordan
  • 6 Department of Pathology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt., Assuit, Egypt
  • 7 Department of Oral pathology department, Faculty of Dentistry, Tanta University, Tanta, Gharbia, Egypt
  • 8 Department of anatomy, Faculty of Medicine in Damietta, Al-Azhar University, New Damietta, Egypt

The final, formatted version of the article will be published soon.

    The purpose of this study is to evaluate the impacts of apricot kernels and caffeine on blood glucose, lipid profile, insulin secretion and antioxidant effect in diabetic rats. Forty adult male albino rats were divided into five groups: normal control, diabetic control, diabetic treated with apricot kernels, diabetic treated with caffeine and diabetic rats treated with apricot kernels plus caffeine. Fasting samples were collected at the end of the study for analysis, and pieces of liver and pancreatic tissues were removed for histological analysis. There was a significant decrease in blood glucose level, glycated hemoglobin, body weight, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C) and a significant increase in insulin and high-density lipoprotein cholesterol (HDL-C) levels in the kernel and caffeine-treated groups. However, there was little histological alteration in the liver or pancreas and no significant difference in the histological findings between groups. Overall, it can be concluded that apricot kernel and caffeine had a positive effect in decreasing blood glucose and harmful lipid profile and that caffeine had a synergetic effect on the apricot kernel.

    Keywords: type 2 diabetes mellitus, Apricot kernels, Caffine, Antio×idant, nutritarian

    Received: 19 Dec 2023; Accepted: 22 May 2024.

    Copyright: © 2024 Nour El-Deen, Taha, Elsayed, Ali and Taha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ahmed E. Nour El-Deen, Department of basic medical and dental sciences, Faculty of Dentistry,, Zarqa University, Zarqa, 13110, Zarqa, Jordan
    Almoatazbellah Elsayed, Department of basic medical and dental sciences, Faculty of Dentistry, Zarqa University, Zarqa, 13110, Zarqa, Jordan
    Ahmed N. Ali, Department of basic medical and dental sciences, Faculty of Dentistry, Zarqa University, Zarqa, 13110, Zarqa, Jordan
    Reda S. Taha, Department of basic medical and dental sciences, Faculty of Dentistry, Zarqa University, Zarqa, 13110, Zarqa, Jordan

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