ORIGINAL RESEARCH article
Front. Neuroanat.
Volume 19 - 2025 | doi: 10.3389/fnana.2025.1566835
This article is part of the Research Topic15 Years of Frontiers in Neuroanatomy: The Origin of Parkinson´s DiseaseView all 4 articles
A Domain-Based Framework for Cognitive Profile Identification in Parkinson's Disease Across Diverse Samples
Provisionally accepted
Elvira Andújar-Castillo1*
Carla Carrillo-Molina1
Fernando Alonso2
Clara Villanueva-Iza2,3Gustavo Fernández-Pajarín4
Angel Sesar4
Isabel Jiménez Martín4Juan Francisco Martín-Rodriguez5,6
Pablo Mir5,6,7Maria Jesús Lama5
Cristina Nombela Otero1*
Elena Perez-Hernandez8*- 1Departamento de Psicología Biológica y de la Salud, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, Madrid, Spain
- 2Centro Integral en Neurociencias A.C. HM CINAC, Móstoles, Madrid, Spain
- 3Departamento de neurología, Instituto de Investigación Sanitaria San Carlos (IdISSC), Hospital Clínico San Carlos, Madrid, Spain
- 4Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Galicia, Spain
- 5Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC., Sevilla, Spain
- 6Centro de Investigacion Biomedica sobre Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain
- 7Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
- 8Department of Evolutionary and Education, Faculty of Psychology, Autonomous University of Madrid, Madrid, Madrid, Spain
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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor symptoms and heterogeneous cognitive impairments influenced by factors such as age, disease duration, and severity. Traditional neuropsychological assessments often fall short in capturing the multifaceted nature of PD-related cognitive dysfunction due to their reliance on single-test metrics. This study provides empirical support for the implementation of domain-based cognitive assessments, structured in line with Movement Disorder Society recommendations, to provide a multidimensional evaluation of cognitive profiles in PD patients.Neuropsychological and clinical data were analyzed from 316 PD patients recruited from three Spanish hospitals-Hospital Clínico San Carlos (Madrid),
Keywords: Parkinson's disease, Cognitive Domains, neuropsychological assessment, Latent cluster analysis, Aging, Deep Brain Stimulation
Received: 25 Jan 2025; Accepted: 23 May 2025.
Copyright: © 2025 Andújar-Castillo, Carrillo-Molina, Alonso, Villanueva-Iza, Fernández-Pajarín, Sesar, Jiménez Martín, Martín-Rodriguez, Mir, Lama, Nombela Otero and Perez-Hernandez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Elvira Andújar-Castillo, Departamento de Psicología Biológica y de la Salud, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, 28049, Madrid, Spain
Cristina Nombela Otero, Departamento de Psicología Biológica y de la Salud, Facultad de Psicología, Universidad Autónoma de Madrid, Madrid, 28049, Madrid, Spain
Elena Perez-Hernandez, Department of Evolutionary and Education, Faculty of Psychology, Autonomous University of Madrid, Madrid, 28049, Madrid, Spain
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