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REVIEW article

Front. Neuroanat.

Volume 19 - 2025 | doi: 10.3389/fnana.2025.1679993

This article is part of the Research TopicReviews in Neuroanatomy: 2024-2025View all articles

Pioneers of modern brain research – Cécile & Oskar Vogt and the Nobel Prize

Provisionally accepted
  • 1Heinrich-Heine-Universitat Dusseldorf Medizinische Fakultat, Düsseldorf, Germany
  • 2Julich Research Center, Helmholtz Association of German Research Centres (HZ), Jülich, Germany

The final, formatted version of the article will be published soon.

This article explores the complex and ultimately unsuccessful Nobel Prize trajectories of Oskar (1870–1959) and Cécile Vogt (1875–1962), as well as their ongoing scientific legacy. Their legacy sheds light on the background to the decision from different perspectives. Despite multiple nominations, the couple never received the Nobel Prize in Physiology or Medicine. Drawing upon archival sources from the Nobel Forum and the Vogt Archive in Düsseldorf, we reconstruct the history of their candidacies, the reasons why they were proposed, and those behind the committee's repeated rejections. Their work on cyto-and myeloarchitectonics, the functional anatomy of the basal ganglia, and structure-function relationships in the cerebral cortex earned them international recognition. However, the Nobel Committee remained unconvinced, often citing issues of scientific priority, insufficient novelty, and the controversial nature of some of their claims. Despite their exclusion from the prize, the Vogts' research shaped the development of brain science across Europe and beyond, influencing later Nobel laureates and contributing to foundational concepts in neuroanatomy and -physiology. Their case invites reflection on the historical contingencies of scientific recognition and the shifting criteria for what counts as a "discovery" worthy of the Nobel Prize.

Keywords: myeloarchitecture, Brain Mapping, research concepts, history of neuroscience, brain research

Received: 05 Aug 2025; Accepted: 03 Sep 2025.

Copyright: © 2025 Hansson, Fangerau, de Sio, Grell and Amunts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Katrin Amunts, Julich Research Center, Helmholtz Association of German Research Centres (HZ), Jülich, Germany

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