Research Topic

Brain Modifications in Response to Stress: From Cellular to Circuit Reorganization

About this Research Topic

Stressful experiences are woven into the tapestry of our lives. Since the pioneering work of Hans Selye in the 1930s, our understanding of how stressful experiences impact the brain, behavior, and cellular function has progressed considerably. We now know that discrete neural circuits control both our ...

Stressful experiences are woven into the tapestry of our lives. Since the pioneering work of Hans Selye in the 1930s, our understanding of how stressful experiences impact the brain, behavior, and cellular function has progressed considerably. We now know that discrete neural circuits control both our behavioral and cellular response to stress. Moreover, we better appreciate how this relationship is reciprocal: stressful experiences can also modify neural circuits and cellular function. Importantly, research in the past decade has provided great insight into the parametric constraints (e.g., chronicity, time of occurrence in the lifespan, etc.) by which stressful experiences influence neural circuits and cellular function.

The goal of this Research Topic is to bring together researchers in the field of neuroscience, broadly defined, to examine how stressful experiences modify neural circuits and cellular function. We seek to provide an up-to-date view on the neurobiological mechanisms of stress. Specifically, we are interested in synergizing different perspectives on how stressful experiences in humans and rodents influence: genes, cellular pathways, neural circuits, immune function, behavior, memory, and more. We are particularly interested in expanding our understanding of how the duration (i.e., chronicity) and timing (across the lifespan) of stressful experiences impacts neural circuits, genes, etc. We are also interested in highlighting newer views and perspectives on how stressful experiences impact the brain and behavior.

We are particularly interested in original research, reviews, mini-reviews, opinions, and perspectives that focus on the following areas:
• Neural circuits of stress,
• Stress-related cellular signaling pathways,
• Stress and immune function,
• Stress and behavior,
• The neurobiological impact of stressful experiences,
• The neurobiological impact of chronic vs acute stress,
• How stress across the lifespan influences neurobiological function, and
• Interactions between the neural circuits of stress and fear


Keywords: fear, stress, memory, neuron, neural circuits


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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