About this Research Topic
Several higher order computational operations are believed to take place in the dentate gyrus. For example, the dentate gyrus is involved in pattern separation, converting relatively similar inputs into substantially different outputs. Thus, the dentate gyrus may act as a preprocessor of incoming information, preparing it for efficient storage in the hippocampal CA3 region. How these complex functions are generated at the cellular and synaptic level has remained largely unclear. In this series of papers, we plan to generate a database of structure, function, and plasticity of the cells and synapses in the dentate gyrus neuronal network. We will cover neuroscience at the molecular, cellular, systems, and computational level. Specifically, we plan to present original publications and focused reviews on the following topics:
- Connectivity in the dentate gyrus.
- Structure of synapses in the dentate gyrus.
- Function of glutamatergic synapses the circuit.
- Function of GABAergic synapses in the circuit (dentate gyrus interneurons).
- Mechanisms of synaptic plasticity in the dentate gyrus.
- Functional relevance of adult neurogenesis.
- Network activity in the dentate gyrus in vitro and in vivo.
- Network oscillations in the dentate gyrus.
- Network models of the dentate gyrus.
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