Brain Injury after Hypoxia/Ischemia: Mechanisms, Pathogenesis, and Potential Therapeutic Interventions

Brain injury resulting from hypoxia (oxygen deprivation) or ischemia (restricted blood flow) represents a major challenge in medical research and clinical practice. Such injuries, often due to stroke, cardiac arrest, or asphyxiation, lead to significant consequences, including motor deficits, cognitive impairments, and increased mortality. The pathogenesis of these injuries involves a complex interplay of cellular and molecular events, including oxidative stress, inflammation, metabolic disruptions, excitotoxicity, and apoptosis. A deep understanding of these mechanisms is essential for developing effective therapeutic interventions. This research topic aims to thoroughly investigate the mechanisms driving hypoxia/ischemia-induced brain injury and identify novel therapeutic strategies to mitigate damage, promoting neuronal recovery and survival.

The primary goal of this research topic is to comprehensively understand the mechanisms and pathogenesis underlying brain injury following hypoxia/ischemia. By elucidating these mechanisms, researchers can identify novel therapeutic targets and strategies to mitigate its severe impacts. Recent advances in molecular biology, neuroimaging, and bioengineering offer new tools and insights to drive this research forward. Through collaborative interdisciplinary research efforts, incorporating both basic science and clinical studies, the goal is to translate these discoveries into effective clinical interventions, thereby improving patient outcomes and reducing the burden of disability associated with hypoxia/ischemia-induced brain injury.

This Research Topic aims to delve into the multifaceted aspects of brain injury following hypoxia/ischemia, focusing on elucidating the underlying mechanisms, pathogenesis, and exploring potential therapeutic interventions. We welcome contributions addressing various themes within this scope, including but not limited to:

· Molecular and cellular mechanisms underlying hypoxic/ischemic brain injury.
· Automated analysis techniques to characterize structural alterations and inflammation in the affected brain.
· The role of neuroinflammation, metabolism, and oxidative stress in brain injury pathogenesis
· Neuroimaging and bioengineering studies revealing structural and functional alterations in the hypoxic/ischemic brain.
· Utilization of preclinical models and experimental approaches for studying hypoxia/ischemia-induced brain injury.

We encourage submissions of original research articles, reviews, mini-reviews, perspectives, and clinical studies that contribute to advancing our understanding of brain injury after hypoxia/ischemia and offer insights into potential therapeutic interventions.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Registered Report
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Brain Ijury, Cardiac arrest, hypoxia, ischemia, strike, microglia, nueronal degeneration, astrocyte, selective vulnerability, behavioral deficits

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.