Lapachone | List of Frontiers open access articles

Original Research

Published on 05 Oct 2021

β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation

in Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

Wenxiu Zhao
Lingxiang Jiang
Ting Fang
Fei Fang
Yingchun Liu
Ye Zhao
Yuting You
Hao Zhou
Xiaolin Su
Jiangwei Wang

Frontiers in Oncology

doi 10.3389/fonc.2021.747282

6,816 views
30 citations

Original Research

Published on 20 Feb 2025

β-lapachone suppresses carcinogenesis of cervical cancer via interaction with AKT1

in Pharmacology of Anti-Cancer Drugs

Pan Du
Yue Li
Anna Han
Mengying Wang
Jiajing Liu
Yingshi Piao
Liyan Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509568

2,673 views
3 citations

Original Research

Published on 11 Nov 2020

MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer

in Radiation Oncology

Kirtikar Shukla
Naveen Singh
Joshua E. Lewis
Allen W. Tsang
David A. Boothman
Melissa L. Kemp
Cristina M. Furdui

Frontiers in Oncology

doi 10.3389/fonc.2020.536377

5,644 views
14 citations

Review

Published on 19 Aug 2020

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

in Radiation Oncology

Colton L. Starcher
S. Louise Pay
Naveen Singh
I-Ju Yeh
Snehal B. Bhandare
Xiaolin Su
Xiumei Huang
Erik A. Bey
Edward A. Motea
David A. Boothman

Frontiers in Oncology

doi 10.3389/fonc.2020.01575

6,806 views
17 citations

Original Research

Published on 02 May 2023

Injectable thermo-sensitive hydrogel loaded hollow copper sulfide nanoparticles for ROS burst in TME and effective tumor treatment

in Nanobiotechnology

Shipeng Ning
Jianlan Mo
Rong Huang
Benkun Liu
Bicheng Fu
Shuaijie Ding
Huawei Yang
Ying Cui
Lei Yao

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1191014

4,608 views
16 citations

Perspective

Accepted on 09 Feb 2026

Perspective: Systems Biology Can Provide Guidance to Synthetic Biology in the Pursuit of New Drug Targets

in Experimental Pharmacology and Drug Discovery

Eberhard Otto Voit

Frontiers in Pharmacology

Articles

β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation

β-lapachone suppresses carcinogenesis of cervical cancer via interaction with AKT1

MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

Injectable thermo-sensitive hydrogel loaded hollow copper sulfide nanoparticles for ROS burst in TME and effective tumor treatment

Perspective: Systems Biology Can Provide Guidance to Synthetic Biology in the Pursuit of New Drug Targets