Ada2 | List of Frontiers open access articles

Original Research

Published on 18 May 2022

Distinct Roles of Adenosine Deaminase Isoenzymes ADA1 and ADA2: A Pan-Cancer Analysis

in Cancer Immunity and Immunotherapy

Zhao-wei Gao
Lan Yang
Chong Liu
Xi Wang
Wen-tao Guo
Hui-zhong Zhang
Ke Dong

Frontiers in Immunology

doi 10.3389/fimmu.2022.903461

16,386 views
30 citations

Original Research

Published on 30 Sep 2022

Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates type I IFN responsive gene expression

in Inflammation

Sarah M. Bowers
Martina Sundqvist
Paul Dancey
David A. Cabral
Kelly L. Brown

Frontiers in Immunology

doi 10.3389/fimmu.2022.995191

4,901 views
2 citations

Original Research

Published on 14 Aug 2025

Developing and validating anti-ADA2 single-chain antibodies coupled to alkaline phosphatase for diagnosing pleural tuberculosis

in Inflammation

Maksym Skaldin
José M. Porcel
Urpo Lamminmäki
Silvia Bielsa
Andrey V. Zavialov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646134

2,138 views
1 citation

Case Report

Published on 03 May 2023

Case Report: Interindividual variability and possible role of heterozygous variants in a family with deficiency of adenosine deaminase 2: are all heterozygous born equals?

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Federica Pulvirenti
Bianca Laura Cinicola
Simona Ferrari
Daniele Guadagnolo
Eleonora Sculco
Martina Capponi
Lorenzo Loffredo
Maddalena Sciannamea
Antonella Insalaco
Isabella Quinti

Frontiers in Immunology

doi 10.3389/fimmu.2023.1156689

4,546 views
2 citations

Original Research

Published on 27 Aug 2025

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Weiping Yang
Qing Zhou
Jose M. Porcel
Jun Wang
Chengxiang Wu
Andrey V. Zavialov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633219

2,418 views

Original Research

Published on 28 Jul 2022

ELISA based assays to measure adenosine deaminases concentration in serum and saliva for the diagnosis of ADA2 deficiency and cancer

in Autoimmune and Autoinflammatory Disorders

Wenwen Luo
Liang Dong
Fenghong Chen
Wenbin Lei
Liya He
Qing Zhou
Thierry Lamy
Andrey V. Zavialov

Frontiers in Immunology

doi 10.3389/fimmu.2022.928438

7,993 views
14 citations

Brief Research Report

Published on 14 Jun 2022

The Growing Spectrum of DADA2 Manifestations—Diagnostic and Therapeutic Challenges Revisited

in Pediatric Immunology

Carolin Escherich
Benedikt Bötticher
Stefani Harmsen
Marc Hömberg
Jörg Schaper
Myriam Ricarda Lorenz
Klaus Schwarz
Arndt Borkhardt
Prasad Thomas Oommen

Frontiers in Pediatrics

doi 10.3389/fped.2022.885893

5,525 views
8 citations

Original Research

Published on 20 Sep 2022

The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid

in Brain Disease Mechanisms

Barbara Kutryb-Zajac
Ada Kawecka
Fionä Caratis
Krzysztof Urbanowicz
Alicja Braczko
Tomomi Furihata
Bartosz Karaszewski
Ryszard T. Smolenski
Aleksandra Rutkowska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2022.998023

6,245 views
17 citations

Original Research

Published on 27 May 2021

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

in Vaccines and Molecular Therapeutics

Oludare A. Odumade
Alec L. Plotkin
Jensen Pak
Olubukola T. Idoko
Matthew A. Pettengill
Tobias R. Kollmann
Al Ozonoff
Beate Kampmann
Ofer Levy
Kinga K. Smolen

Frontiers in Immunology

doi 10.3389/fimmu.2021.578700

7,949 views
10 citations

Case Report

Published on 09 Sep 2022

Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency

in Autoimmune and Autoinflammatory Disorders

Enrico Drago
Francesca Garbarino
Sara Signa
Alice Grossi
Francesca Schena
Federica Penco
Elettra Santori
Fabio Candotti
Kaan Boztug
Stefano Volpi

Frontiers in Immunology

doi 10.3389/fimmu.2022.937108

6,235 views
12 citations

Original Research

Published on 26 Mar 2019

A Potential Antifungal Effect of Chitosan Against Candida albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity

in Fungi and Their Interactions

Pei-Yu Shih
Yu-Ting Liao
Yi-Kai Tseng
Fu-Sheng Deng
Ching-Hsuan Lin

Frontiers in Microbiology

doi 10.3389/fmicb.2019.00602

21,305 views
142 citations

Original Research

Published on 22 Apr 2022

Lentiviral Mediated ADA2 Gene Transfer Corrects the Defects Associated With Deficiency of Adenosine Deaminase Type 2

in Autoimmune and Autoinflammatory Disorders

Ying Hong
Marina Casimir
Benjamin C. Houghton
Fang Zhang
Barbara Jensen
Ebun Omoyinmi
Robert Torrance
Charalampia Papadopoulou
Michelle Cummins
Marion Roderick

Frontiers in Immunology

doi 10.3389/fimmu.2022.852830

6,962 views
16 citations

Case Report

Published on 03 Feb 2026

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Szymon Lulek
Katarzyna Bąbol-Pokora
Monika Radwańska
Daniel Popiel
Magdalena Reich
Wojciech Młynarski
Radosław Chaber

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717567

678 views

Original Research

Published on 02 Oct 2025

Early-onset neutropenia and mixed phenotype in ADA2 deficiency: diagnostic and therapeutic challenges

in Primary Immunodeficiencies

Sibel Kaplan Sarıkavak
Özge Türkyılmaz Uçar
Burcu Cil
Michael S. Hershfield
Teresa K. Tarrant
Pinar Gökmirza
Çiğdem Aydoğmus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639318

3,529 views

Mini Review

Published on 03 May 2022

Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist

in Primary Immunodeficiencies

Rakesh Kumar Pilania
Aaqib Zaffar Banday
Saniya Sharma
Rajni Kumrah
Vibhu Joshi
Sathish Loganathan
Manpreet Dhaliwal
Ankur Kumar Jindal
Pandiarajan Vignesh
Deepti Suri

Frontiers in Immunology

doi 10.3389/fimmu.2022.869570

8,937 views
24 citations

Mini Review

Published on 11 Jul 2022

Adenosine Deaminase 2 Deficiency (DADA2): A Crosstalk Between Innate and Adaptive Immunity

in Autoimmune and Autoinflammatory Disorders

Sara Signa
Arinna Bertoni
Federica Penco
Roberta Caorsi
Alessia Cafaro
Giuliana Cangemi
Stefano Volpi
Marco Gattorno
Francesca Schena

Frontiers in Immunology

doi 10.3389/fimmu.2022.935957

14,449 views
40 citations

Articles

Distinct Roles of Adenosine Deaminase Isoenzymes ADA1 and ADA2: A Pan-Cancer Analysis

Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates type I IFN responsive gene expression

Developing and validating anti-ADA2 single-chain antibodies coupled to alkaline phosphatase for diagnosing pleural tuberculosis

Case Report: Interindividual variability and possible role of heterozygous variants in a family with deficiency of adenosine deaminase 2: are all heterozygous born equals?

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

ELISA based assays to measure adenosine deaminases concentration in serum and saliva for the diagnosis of ADA2 deficiency and cancer

The Growing Spectrum of DADA2 Manifestations—Diagnostic and Therapeutic Challenges Revisited

The impaired distribution of adenosine deaminase isoenzymes in multiple sclerosis plasma and cerebrospinal fluid

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency

A Potential Antifungal Effect of Chitosan Against Candida albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity

Lentiviral Mediated ADA2 Gene Transfer Corrects the Defects Associated With Deficiency of Adenosine Deaminase Type 2

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

Early-onset neutropenia and mixed phenotype in ADA2 deficiency: diagnostic and therapeutic challenges

Deficiency of Human Adenosine Deaminase Type 2 – A Diagnostic Conundrum for the Hematologist

Adenosine Deaminase 2 Deficiency (DADA2): A Crosstalk Between Innate and Adaptive Immunity