Adenosine Deaminase 2 | List of Frontiers open access articles

Case Report

Published on 15 Jan 2025

Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency

in Genetics of Common and Rare Diseases

Haishao Yu
Shuangzhu Lin
Lin Li
Jiayi Li
Qiandui Chen
Yuheng Wu
Yangfan Qi
Wanqi Wang
Xingzhi Chang
Jie Zhang

Frontiers in Genetics

doi 10.3389/fgene.2024.1478581

2,392 views
1 citation

Mini Review

Published on 10 Oct 2022

Recent topics related to etiology and clinical manifestations of cutaneous arteritis

in Dermatology

Takaharu Ikeda

Frontiers in Medicine

doi 10.3389/fmed.2022.1022512

3,980 views
3 citations

Brief Research Report

Published on 14 Jun 2022

The Growing Spectrum of DADA2 Manifestations—Diagnostic and Therapeutic Challenges Revisited

in Pediatric Immunology

Carolin Escherich
Benedikt Bötticher
Stefani Harmsen
Marc Hömberg
Jörg Schaper
Myriam Ricarda Lorenz
Klaus Schwarz
Arndt Borkhardt
Prasad Thomas Oommen

Frontiers in Pediatrics

doi 10.3389/fped.2022.885893

5,569 views
8 citations

Original Research

Published on 27 Aug 2025

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Weiping Yang
Qing Zhou
Jose M. Porcel
Jun Wang
Chengxiang Wu
Andrey V. Zavialov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633219

2,455 views

Case Report

Published on 14 Jun 2018

Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences

in Inflammation

Jason Michael Springer
Selina A. Gierer
Hong Jiang
David Kleiner
Natalie Deuitch
Amanda K. Ombrello
Peter C. Grayson
Ivona Aksentijevich

Frontiers in Immunology

doi 10.3389/fimmu.2018.01361

8,028 views
53 citations

Case Report

Published on 29 Apr 2021

Case Report: An Adult Patient With Deficiency of Adenosine Deaminase 2 Resembled Unilateral Frosted Branch Angiitis

in Ophthalmology

Yufeng Xu
Yi Shan
Yin Hu
Jing Cao
Yijie Wang
Lixia Lou
Panpan Ye

Frontiers in Medicine

doi 10.3389/fmed.2021.642454

6,011 views
16 citations

Mini Review

Published on 18 Oct 2018

Vasculopathy, Immunodeficiency, and Bone Marrow Failure: The Intriguing Syndrome Caused by Deficiency of Adenosine Deaminase 2

in Pediatric Immunology

Pui Y. Lee

Frontiers in Pediatrics

doi 10.3389/fped.2018.00282

16,153 views
85 citations

Case Report

Published on 14 Jun 2023

Case Report: Patient with deficiency of ADA2 presenting leukocytoclastic vasculitis and pericarditis during infliximab treatment

in Pediatric Immunology

Diana Simão Raimundo
Ana Isabel Cordeiro
João Parente Freixo
Marta Valente Pinto
Conceição Neves
João Farela Neves

Frontiers in Pediatrics

doi 10.3389/fped.2023.1200401

4,015 views
3 citations

Case Report

Published on 29 Sep 2022

Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency

in Autoimmune and Autoinflammatory Disorders

Federica Barzaghi
Maria Pia Cicalese
Matteo Zoccolillo
Immacolata Brigida
Matteo Barcella
Ivan Merelli
Claudia Sartirana
Monica Zanussi
Valeria Calbi
Maria Ester Bernardo

Frontiers in Immunology

doi 10.3389/fimmu.2022.910021

5,548 views
9 citations

Case Report

Published on 09 Sep 2022

Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency

in Autoimmune and Autoinflammatory Disorders

Enrico Drago
Francesca Garbarino
Sara Signa
Alice Grossi
Francesca Schena
Federica Penco
Elettra Santori
Fabio Candotti
Kaan Boztug
Stefano Volpi

Frontiers in Immunology

doi 10.3389/fimmu.2022.937108

6,273 views
12 citations

Mini Review

Published on 11 Jul 2022

Adenosine Deaminase 2 Deficiency (DADA2): A Crosstalk Between Innate and Adaptive Immunity

in Autoimmune and Autoinflammatory Disorders

Sara Signa
Arinna Bertoni
Federica Penco
Roberta Caorsi
Alessia Cafaro
Giuliana Cangemi
Stefano Volpi
Marco Gattorno
Francesca Schena

Frontiers in Immunology

doi 10.3389/fimmu.2022.935957

14,509 views
42 citations

Case Report

Published on 14 Oct 2021

Case Report: Deficiency of Adenosine Deaminase 2 Presenting With Overlapping Features of Autoimmune Lymphoproliferative Syndrome and Bone Marrow Failure

in Primary Immunodeficiencies

Gianluca Dell’Orso
Alice Grossi
Federica Penco
Roberta Caorsi
Elena Palmisani
Paola Terranova
Francesca Schena
Michela Lupia
Erica Ricci
Shana Montalto

Frontiers in Immunology

doi 10.3389/fimmu.2021.754029

7,585 views
18 citations

Mini Review

Published on 07 Jul 2022

Allogeneic Hematopoietic Cell Transplantation for Patients With Deficiency of Adenosine Deaminase 2 (DADA2): Approaches, Obstacles and Special Considerations

in Autoimmune and Autoinflammatory Disorders

Hasan Hashem
Dimana Dimitrova
Isabelle Meyts

Frontiers in Immunology

doi 10.3389/fimmu.2022.932385

6,734 views
21 citations

Case Report

Published on 27 Oct 2021

COVID-19 Pneumomediastinum: Possible Role of Transesophageal Echo in Bedside Percutaneous Bicaval Double-Lumen ECMO Cannulation in Children. A Case Report

in Pediatric Critical Care

Andrea Moscatelli
Stefano Pezzato
Silvia Buratti
Elisabetta Lampugnani
Alberto Di Mascio
Maria Beatrice Damasio
Roberta Caorsi
Marco Gattorno
Elio Castagnola

Frontiers in Pediatrics

doi 10.3389/fped.2021.740853

2,978 views
5 citations

Case Report

Published on 03 Feb 2026

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Szymon Lulek
Katarzyna Bąbol-Pokora
Monika Radwańska
Daniel Popiel
Magdalena Reich
Wojciech Młynarski
Radosław Chaber

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717567

751 views

Case Report

Published on 14 Jan 2019

ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation

in Primary Immunodeficiencies

Federica Barzaghi
Federica Minniti
Margherita Mauro
Massimiliano De Bortoli
Rita Balter
Elisa Bonetti
Ada Zaccaron
Virginia Vitale
Maryam Omrani
Matteo Zoccolillo

Frontiers in Immunology

doi 10.3389/fimmu.2018.02767

7,267 views
46 citations

Articles

Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency

Recent topics related to etiology and clinical manifestations of cutaneous arteritis

The Growing Spectrum of DADA2 Manifestations—Diagnostic and Therapeutic Challenges Revisited

A rapid antigen test to detect adenosine deaminase 2 (ADA2) in biological fluids and its application in clinical diagnostics

Deficiency of Adenosine Deaminase 2 in Adult Siblings: Many Years of a Misdiagnosed Disease With Severe Consequences

Case Report: An Adult Patient With Deficiency of Adenosine Deaminase 2 Resembled Unilateral Frosted Branch Angiitis

Vasculopathy, Immunodeficiency, and Bone Marrow Failure: The Intriguing Syndrome Caused by Deficiency of Adenosine Deaminase 2

Case Report: Patient with deficiency of ADA2 presenting leukocytoclastic vasculitis and pericarditis during infliximab treatment

Case Report: Consistent disease manifestations with a staggered time course in two identical twins affected by adenosine deaminase 2 deficiency

Case Report: Susceptibility to viral infections and secondary hemophagocytic lymphohistiocytosis responsive to intravenous immunoglobulin as primary manifestations of adenosine deaminase 2 deficiency

Adenosine Deaminase 2 Deficiency (DADA2): A Crosstalk Between Innate and Adaptive Immunity

Case Report: Deficiency of Adenosine Deaminase 2 Presenting With Overlapping Features of Autoimmune Lymphoproliferative Syndrome and Bone Marrow Failure

Allogeneic Hematopoietic Cell Transplantation for Patients With Deficiency of Adenosine Deaminase 2 (DADA2): Approaches, Obstacles and Special Considerations

COVID-19 Pneumomediastinum: Possible Role of Transesophageal Echo in Bedside Percutaneous Bicaval Double-Lumen ECMO Cannulation in Children. A Case Report

A fatal course of hemophagocytic lymphohistiocytosis in a child with homozygous ERCC6L2 defect and heterozygous ADA2 variant: a case report

ALPS-Like Phenotype Caused by ADA2 Deficiency Rescued by Allogeneic Hematopoietic Stem Cell Transplantation