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4 articles related to "Bioreductive"

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Articles

Original Research

Published on 11 Aug 2017

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

in Experimental Pharmacology and Drug Discovery

Yongchuan Gu
Tony T.-A. Chang
Jingli Wang
Jagdish K. Jaiswal
David Edwards
Noel J. Downes
H. D. Sarath Liyanage
Courtney R. H. Lynch
Frederik B. Pruijn
Anthony J. R. Hickey

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00531

5,230 views
17 citations

Systematic Review

Published on 29 Jul 2021

Targeting Hypoxia: Hypoxia-Activated Prodrugs in Cancer Therapy

in Pharmacology of Anti-Cancer Drugs

Yue Li
Long Zhao
Xiao-Feng Li

Frontiers in Oncology

doi 10.3389/fonc.2021.700407

23,761 views
154 citations

Original Research

Published on 08 Feb 2022

Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

in Translational Pharmacology

Victoria Jackson-Patel
Emily Liu
Matthew R. Bull
Amir Ashoorzadeh
Gib Bogle
Anna Wolfram
Kevin O. Hicks
Jeff B. Smaill
Adam V. Patterson

Frontiers in Pharmacology

doi 10.3389/fphar.2022.803602

4,447 views
4 citations

Original Research

Published on 05 Dec 2016

Mechanisms of Antibacterial Action of Quinoxaline 1,4-di-N-oxides against Clostridium perfringens and Brachyspira hyodysenteriae

in Antimicrobials, Resistance and Chemotherapy

Fanfan Xu
Guyue Cheng
Haihong Hao
Yulian Wang
Xu Wang
Dongmei Chen
Dapeng Peng
Zhenli Liu
Zonghui Yuan
Menghong Dai

Frontiers in Microbiology

doi 10.3389/fmicb.2016.01948

6,557 views
27 citations