Clinical Breakpoint | List of Frontiers open access articles

Original Research

Published on 09 Sep 2021

Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift

in Antimicrobials, Resistance and Chemotherapy

Anxiong Huang
Shuge Wang
Jinli Guo
Yufeng Gu
Jun Li
Lingli Huang
Xu Wang
Yanfei Tao
Zhenli Liu
Zonghui Yuan

Frontiers in Microbiology

doi 10.3389/fmicb.2021.712473

17,709 views
12 citations

Original Research

Published on 24 Feb 2022

Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study

in Drug Metabolism and Transport

Anxiong Huang
Xun Luo
Zihui Xu
Lingli Huang
Xu Wang
Shuyu Xie
Yuanhu Pan
Shiwei Fang
Zhenli Liu
Zonghui Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2022.769539

3,537 views

Original Research

Published on 25 Oct 2023

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

in Antimicrobials, Resistance and Chemotherapy

Elodie A. Lallemand
Alain Bousquet-Mélou
Laura Chapuis
Jennifer Davis
Aude A. Ferran
Butch Kukanich
Taisuke Kuroda
Marlène Z. Lacroix
Yohei Minamijima
Lena Olsén

Frontiers in Microbiology

doi 10.3389/fmicb.2023.1282949

7,699 views
11 citations

Original Research

Published on 12 Jun 2019

VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle

in Antimicrobials, Resistance and Chemotherapy

Pierre-Louis Toutain
Pritam Kaur Sidhu
Peter Lees
Ali Rassouli
Ludovic Pelligand

Frontiers in Microbiology

doi 10.3389/fmicb.2019.01310

9,231 views
32 citations

Original Research

Published on 04 Dec 2024

Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modeling

in Antimicrobials, Resistance and Chemotherapy

Esther A. Winter
Ludovic Pelligand
Pierre-Louis Toutain
Peter Lees
Aneliya Milanova
Ronette Gehring

Frontiers in Microbiology

doi 10.3389/fmicb.2024.1498219

2,931 views

Original Research

Published on 05 Dec 2023

Metabolomics reveals the mechanism of action of meropenem and amikacin combined in the treatment of Pseudomonas aeruginosa

in Antibiotic Resistance and New Antimicrobial drugs

Hai Yang
Zhen Huang
Jiali Yue
Jianqi Chen
Mingming Yu
Chengming Qu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2023.1327452

6,216 views
6 citations

Original Research

Published on 15 Nov 2021

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs

in Veterinary Emergency and Critical Care Medicine

Maria D. Vegas Cómitre
Stefano Cortellini
Marc Cherlet
Mathias Devreese
Beatrice B. Roques
Alain Bousquet-Melou
Pierre-Louis Toutain
Ludovic Pelligand

Frontiers in Veterinary Science

doi 10.3389/fvets.2021.770202

18,719 views
18 citations

Original Research

Published on 22 Mar 2017

Notable Increasing Trend in Azole Non-susceptible Candida tropicalis Causing Invasive Candidiasis in China (August 2009 to July 2014): Molecular Epidemiology and Clinical Azole Consumption

in Antimicrobials, Resistance and Chemotherapy

Xin Fan
Meng Xiao
Kang Liao
Timothy Kudinha
He Wang
Li Zhang
Xin Hou
Fanrong Kong
Ying-Chun Xu

Frontiers in Microbiology

doi 10.3389/fmicb.2017.00464

6,262 views
94 citations

Original Research

Published on 08 Dec 2021

Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization

in Translational Pharmacology

Pier Giorgio Cojutti
Milo Gatti
Matteo Rinaldi
Tommaso Tonetti
Cristiana Laici
Chiara Mega
Antonio Siniscalchi
Maddalena Giannella
Pierluigi Viale
Federico Pea

Frontiers in Pharmacology

doi 10.3389/fphar.2021.781892

4,483 views
18 citations

Original Research

Published on 14 Feb 2025

Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens

in Pharmacology of Infectious Diseases

Hailan Wu
Yi Li
Xin Li
Yaxin Fan
Beining Guo
Xiaofen Liu
Wanzhen Li
Mengting Chen
Yan Chen
Jing Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1476158

2,263 views

Original Research

Published on 26 Jun 2020

Antibiotic Resistance-Susceptibility Profiles of Enterococcus faecalis and Streptococcus spp. From the Human Vagina, and Genome Analysis of the Genetic Basis of Intrinsic and Acquired Resistances

in Antimicrobials, Resistance and Chemotherapy

Auttawit Sirichoat
Ana Belén Flórez
Lucía Vázquez
Pranom Buppasiri
Marutpong Panya
Viraphong Lulitanond
Baltasar Mayo

Frontiers in Microbiology

doi 10.3389/fmicb.2020.01438

17,879 views
28 citations

Original Research

Published on 09 Oct 2018

Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination

in Drug Metabolism and Transport

Petra Cagnardi
Federica Di Cesare
Pierre-Louis Toutain
Alain Bousquet-Mélou
Giuliano Ravasio
Roberto Villa

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01137

7,745 views
14 citations

Articles

Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on Its Clinical Breakpoint and Lung Microbiota Shift

Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study

Pharmacokinetic–pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses

VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle

Determination of pharmacokinetic-pharmacodynamic cutoff values of oxytetracycline in calves and adult cattle using population pharmacokinetic modeling

Metabolomics reveals the mechanism of action of meropenem and amikacin combined in the treatment of Pseudomonas aeruginosa

Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs

Notable Increasing Trend in Azole Non-susceptible Candida tropicalis Causing Invasive Candidiasis in China (August 2009 to July 2014): Molecular Epidemiology and Clinical Azole Consumption

Impact of Maximizing Css/MIC Ratio on Efficacy of Continuous Infusion Meropenem Against Documented Gram-Negative Infections in Critically Ill Patients and Population Pharmacokinetic/Pharmacodynamic Analysis to Support Treatment Optimization

Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens

Antibiotic Resistance-Susceptibility Profiles of Enterococcus faecalis and Streptococcus spp. From the Human Vagina, and Genome Analysis of the Genetic Basis of Intrinsic and Acquired Resistances

Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination