Current Good Manufacturing Practice | List of Frontiers open access articles

Review

Published on 05 Sep 2023

Promises and challenges of a decentralized CAR T-cell manufacturing model

in Cell and Stem Cell Transplantation

Manan Shah
Ashley Krull
Lynn Odonnell
Marcos J. de Lima
Evandro Bezerra

Frontiers in Transplantation

doi 10.3389/frtra.2023.1238535

18,194 views
48 citations

Methods

Published on 05 Aug 2025

Implementation of a quality management system for decentralized manufacturing of cell and gene therapy products - technical and regulatory considerations

in Regulatory Science

Heiko von der Leyen
Julio Delgado
Chaya Mazouz
Michael Schmitt
Vered Caplan

Frontiers in Medicine

doi 10.3389/fmed.2025.1591751

3,527 views
1 citation

Original Research

Published on 27 Feb 2026

Automated manufacturing of clinical-grade BDCA2 CAR NK cells in a closed system for the treatment of blastic plasmacytoid dendritic cell neoplasm

in NK and Innate Lymphoid Cell Biology

Rita Pfeifer
Sabine Müller
Marcus Nitsche
Melanie Sohmen
Julia Kostyra
Arthur Bister
Cathrin Bleilevens
Janina Brauner
Angela Mekes
Juliane Raasch

Frontiers in Immunology

doi 10.3389/fimmu.2026.1761397

115 views

Review

Published on 30 Sep 2022

Understanding plant to extract ratios in botanical extracts

in Ethnopharmacology

Maria Monagas
Thomas Brendler
Josef Brinckmann
Steven Dentali
Stefan Gafner
Gabriel Giancaspro
Holly Johnson
James Kababick
Cuiying Ma
Hellen Oketch-Rabah

Frontiers in Pharmacology

doi 10.3389/fphar.2022.981978

82,710 views
59 citations

Original Research

Published on 09 Mar 2022

GMP-Compliant Production of Autologous Adipose-Derived Stromal Cells in the NANT 001 Closed Automated Bioreactor

in Tissue Engineering and Regenerative Medicine

Joan C. Fitzgerald
Niamh Duffy
Giacomo Cattaruzzi
Francesco Vitrani
Alice Paulitti
Flavia Mazzarol
Prisca Mauro
Antonio Sfiligoj
Francesco Curcio
Deirdre M. Jones

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.834267

7,801 views
10 citations

Original Research

Published on 14 Jan 2022

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

in Nutrition Methodology

Kirsten M. Wright
Janis McFerrin
Armando Alcázar Magaña
Joanne Roberts
Maya Caruso
Doris Kretzschmar
Jan F. Stevens
Claudia S. Maier
Joseph F. Quinn
Amala Soumyanath

Frontiers in Nutrition

doi 10.3389/fnut.2021.799137

11,363 views
18 citations

Original Research

Published on 25 Feb 2020

Characterization of a Cytomegalovirus-Specific T Lymphocyte Product Obtained Through a Rapid and Scalable Production Process for Use in Adoptive Immunotherapy

in T Cell Biology

Marta Grau-Vorster
María López-Montañés
Ester Cantó
Joaquim Vives
Irene Oliver-Vila
Pere Barba
Sergi Querol
Francesc Rudilla

Frontiers in Immunology

doi 10.3389/fimmu.2020.00271

9,410 views
13 citations

Articles

Promises and challenges of a decentralized CAR T-cell manufacturing model

Implementation of a quality management system for decentralized manufacturing of cell and gene therapy products - technical and regulatory considerations

Automated manufacturing of clinical-grade BDCA2 CAR NK cells in a closed system for the treatment of blastic plasmacytoid dendritic cell neoplasm

Understanding plant to extract ratios in botanical extracts

GMP-Compliant Production of Autologous Adipose-Derived Stromal Cells in the NANT 001 Closed Automated Bioreactor

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges

Characterization of a Cytomegalovirus-Specific T Lymphocyte Product Obtained Through a Rapid and Scalable Production Process for Use in Adoptive Immunotherapy