Cyp3a Activity | List of Frontiers open access articles

Original Research

Published on 21 Aug 2020

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

in Pharmacogenetics and Pharmacogenomics

Johannes Matthaei
Wagner Hugo Bonat
Reinhold Kerb
Mladen Vassilev Tzvetkov
Jakob Strube
Stefanie Brunke
Cordula Sachse-Seeboth
Daniel Sehrt
Ute Hofmann
Jacob von Bornemann Hjelmborg

Frontiers in Genetics

doi 10.3389/fgene.2020.00944

4,406 views
22 citations

Review

Published on 16 Jun 2022

Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity

in Pharmacogenetics and Pharmacogenomics

Qinglian Zhai
Maaike van der Lee
Teun van Gelder
Jesse J. Swen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.912618

7,196 views
24 citations

Original Research

Published on 13 Apr 2023

Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

in Drug Metabolism and Transport

Laura Buyssens
Allan Valenzuela
Sara Prims
Miriam Ayuso
Thomas Thymann
Chris Van Ginneken
Steven Van Cruchten

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1177541

3,093 views
2 citations

Original Research

Published on 26 Nov 2025

Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity

in Drug Metabolism and Transport

Muluneh M. Fashe
Jonghwa Lee
Joseph T. Grieco
John K. Fallon
Ian R. Mulrenin
Megan N. Gower
Klarissa D. Jackson
Kim A. Boggess
Craig R. Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702419

1,197 views

Original Research

Published on 17 Sep 2021

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

in Drug Metabolism and Transport

Punyabhorn Rattanacheeworn
Stephen J Kerr
Wonngarm Kittanamongkolchai
Natavudh Townamchai
Suwasin Udomkarnjananun
Kearkiat Praditpornsilpa
Thanundorn Thanusuwannasak
Udomsak Udomnilobol
Suree Jianmongkol
Boonsri Ongpipattanakul

Frontiers in Pharmacology

doi 10.3389/fphar.2021.726669

6,999 views
23 citations

Original Research

Published on 12 Feb 2025

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

in In Vitro Toxicology

Tasnia Sharin
Doug Crump
Jason M. O’Brien

Frontiers in Toxicology

doi 10.3389/ftox.2025.1482865

1,598 views

Original Research

Published on 11 Apr 2025

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

in Drug Metabolism and Transport

Alexander Lenard
Simon A. Hermann
Felicitas Stoll
Juergen Burhenne
Kathrin I. Foerster
David Czock
Gerd Mikus
Andreas D. Meid
Walter E. Haefeli
Antje Blank

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542063

5,553 views
2 citations

Clinical Trial

Published on 27 Sep 2019

Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate

in Drug Metabolism and Transport

Madelé van Dyk
Asha J. Kapetas
Ashley M. Hopkins
A. David Rodrigues
Manoli Vourvahis
Michael J. Sorich
Andrew Rowland

Frontiers in Pharmacology

doi 10.3389/fphar.2019.01120

3,053 views
6 citations

Original Research

Published on 23 Sep 2022

Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker

in Drug Metabolism and Transport

Miao Zhang
Zhiheng Yu
Xueting Yao
Zihan Lei
Kaijing Zhao
Wenqian Wang
Xue Zhang
Xijing Chen
Dongyang Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.972411

3,827 views
11 citations

Articles

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity

Ontogeny of CYP3A and UGT activity in preterm piglets: a translational model for drug metabolism in preterm newborns

Estrogen associations with human pregnancy related increases in cytochrome P450 3A activity

Quantification of CYP3A and Drug Transporters Activity in Healthy Young, Healthy Elderly and Chronic Kidney Disease Elderly Patients by a Microdose Cocktail Approach

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

Validation of a 3-h Sampling Interval to Assess Variability in Cytochrome P450 3A Phenotype and the Impact of Induction and Mechanism-Based Inhibition Using Midazolam as a Probe Substrate

Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker