Ddr Pathway | List of Frontiers open access articles

Original Research

Published on 10 Jan 2022

Patient-Level DNA Damage Repair Pathway Profiles and Anti-Tumor Immunity for Gastric Cancer

in Cancer Immunity and Immunotherapy

Shenghan Lou
Yufei Wang
Jian Zhang
Xin Yin
Yao Zhang
Yimin Wang
Yingwei Xue

Frontiers in Immunology

doi 10.3389/fimmu.2021.806324

8,432 views
21 citations

Original Research

Published on 02 Nov 2021

APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

in Molecular and Cellular Pathology

Md Akram Hossain
Yunfeng Lin
Garrett Driscoll
Jia Li
Anne McMahon
Joshua Matos
Haichao Zhao
Daisuke Tsuchimoto
Yusaku Nakabeppu
Jianjun Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.738502

9,249 views
19 citations

Original Research

Published on 18 Jun 2021

Activation of the DDR Pathway Leads to the Down-Regulation of the TGFβ Pathway and a Better Response to ICIs in Patients With Metastatic Urothelial Carcinoma

in Cancer Immunity and Immunotherapy

Chaozheng Zhou
Anqi Lin
Manming Cao
Weimin Ding
Weiming Mou
Ningyi Guo
Zhenyu Chen
Jian Zhang
Peng Luo

Frontiers in Immunology

doi 10.3389/fimmu.2021.634741

8,319 views
37 citations

Review

Published on 26 Jun 2023

Impact of DNA damage repair alterations on prostate cancer progression and metastasis

in Genitourinary Oncology

Natalia Lukashchuk
Alan Barnicle
Carrie A. Adelman
Joshua Armenia
Jinyu Kang
J. Carl Barrett
Elizabeth A. Harrington

Frontiers in Oncology

doi 10.3389/fonc.2023.1162644

9,897 views
38 citations

Original Research

Published on 29 Mar 2021

Alteration of DNA Damage Response Causes Cleft Palate

in Craniofacial Biology and Dental Research

Hiroyuki Yamaguchi
Kohei Kitami
Xiao Wu
Li He
Jianbo Wang
Bin Wang
Yoshihiro Komatsu

Frontiers in Physiology

doi 10.3389/fphys.2021.649492

4,698 views
7 citations

Review

Published on 05 Jan 2026

The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition

in Cancer Cell Biology

Fabio Giuntini
Jonathan R. Whitfield
Daniel Massó-Vallés
Laura Soucek

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1726515

1,402 views

Review

Published on 23 Feb 2024

For better or worse: crosstalk of parvovirus and host DNA damage response

in Viral Immunology

Songbiao Chen
Feifei Liu
Aofei Yang
Ke Shang

Frontiers in Immunology

doi 10.3389/fimmu.2024.1324531

7,814 views
11 citations

Original Research

Published on 22 Oct 2019

ATR, a DNA Damage Signaling Kinase, Is Involved in Aluminum Response in Barley

in Plant Cell Biology

Miriam Szurman-Zubrzycka
Malgorzata Nawrot
Janusz Jelonek
Mariusz Dziekanowski
Jolanta Kwasniewska
Iwona Szarejko

Frontiers in Plant Science

doi 10.3389/fpls.2019.01299

5,201 views
17 citations

Review

Published on 12 Oct 2021

Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application

in Cancer Immunity and Immunotherapy

Hongyu Xie
Wenjie Wang
Wencai Qi
Weilin Jin
Bairong Xia

Frontiers in Immunology

doi 10.3389/fimmu.2021.661115

8,181 views
14 citations

Perspective

Published on 04 Feb 2015

DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies

in Cancer Genetics

Olga M. Shatnyeva
Hinrich P. Hansen
Katrin S. Reiners
Maike Sauer
Maulik Vyas
Elke Pogge von Strandmann

Frontiers in Genetics

doi 10.3389/fgene.2015.00011

8,702 views
6 citations

Original Research

Published on 19 Aug 2024

MiR-125a-5p regulates the radiosensitivity of laryngeal squamous cell carcinoma via HK2 targeting through the DDR pathway

in Cancer Genetics

Qiwei Wang
Lijun Tan
Yuanhang Lv
Tianjiao Yu
Yuan Chang
Jiangtao Liu
Yanan Sun

Frontiers in Oncology

doi 10.3389/fonc.2024.1438722

2,168 views
3 citations

Case Report

Published on 13 Jul 2023

Case Report: Genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor

in Cancer Immunity and Immunotherapy

Yang Song
Juan Long
Xiaona Su
Zhuo Chen
Yue He
Weikang Shao
Bin Wang
Chuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2023.1197543

4,819 views
5 citations

Case Report

Published on 27 Nov 2025

Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways

in Thoracic Oncology

Jiaqin Song
Shikun Yang
Lei Xia

Frontiers in Oncology

doi 10.3389/fonc.2025.1683301

1,262 views

Original Research

Published on 04 Nov 2022

A novel DNA damage repair-related signature for predicting prognositc and treatment response in non-small lung cancer

in Molecular and Cellular Oncology

Ling Li
Bao-jia Zou
Juan-zhi Zhao
Jia-bi Liang
Zi-yue She
Wen-ying Zhou
Si-xiao Lin
Lin Tian
Wen-ji Luo
Fa-zhong He

Frontiers in Oncology

doi 10.3389/fonc.2022.961274

5,096 views
8 citations

Original Research

Published on 16 Oct 2020

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer

in Molecular and Cellular Oncology

Guangchao Wang
Shichao Guo
Weimin Zhang
Zhangfu Li
Jiancheng Xu
Dan Li
Yan Wang
Qimin Zhan

Frontiers in Oncology

doi 10.3389/fonc.2020.575711

7,603 views
21 citations

Case Report

Published on 10 Apr 2024

Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair

in Pharmacology of Anti-Cancer Drugs

Wenguang He
Congcong Song
Jiwei Ren
Xiao Ji
Xiuyan Wang
Lixia Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1336699

2,085 views
3 citations

Articles

Patient-Level DNA Damage Repair Pathway Profiles and Anti-Tumor Immunity for Gastric Cancer

APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

Activation of the DDR Pathway Leads to the Down-Regulation of the TGFβ Pathway and a Better Response to ICIs in Patients With Metastatic Urothelial Carcinoma

Impact of DNA damage repair alterations on prostate cancer progression and metastasis

Alteration of DNA Damage Response Causes Cleft Palate

The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition

For better or worse: crosstalk of parvovirus and host DNA damage response

ATR, a DNA Damage Signaling Kinase, Is Involved in Aluminum Response in Barley

Targeting DNA Repair Response Promotes Immunotherapy in Ovarian Cancer: Rationale and Clinical Application

DNA damage response and evasion from immunosurveillance in CLL: new options for NK cell-based immunotherapies

MiR-125a-5p regulates the radiosensitivity of laryngeal squamous cell carcinoma via HK2 targeting through the DDR pathway

Case Report: Genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor

Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways

A novel DNA damage repair-related signature for predicting prognositc and treatment response in non-small lung cancer

A Comprehensive Analysis of Alterations in DNA Damage Repair Pathways Reveals a Potential Way to Enhance the Radio-Sensitivity of Esophageal Squamous Cell Cancer

Case report: Robust response to sintilimab in advanced distal cholangiocarcinoma with PD-L1 expression and DNA damage repair