Drugdrug Interaction | List of Frontiers open access articles

Original Research

Published on 29 Oct 2024

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

in In silico Methods and Artificial Intelligence for Drug Discovery

Changqing Yu
Shanwen Zhang
Xuqi Wang
Tailong Shi
Chen Jiang
Sizhe Liang
Guanghao Ma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460672

2,590 views
1 citation

Original Research

Published on 18 Feb 2026

Predicting drug–drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling

in Biological Modeling and Simulation

Gabriella de Souza Gomes Ribeiro
Beatriz Aparecida Passos Bismara Paranhos
Fabiane Dörr
Maurício Yonamine
Bianca Villanova
Lorena Terene Lopes Guerra
Adrieli Oliveira Raminelli
Jose Augusto Silva Reis
Caio Cesar de Paula
Anna Beatriz Vicentini Zacharias

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1768402

794 views

Original Research

Published on 20 Dec 2021

Prediction of the Drug–Drug Interaction Types with the Unified Embedding Features from Drug Similarity Networks

in Experimental Pharmacology and Drug Discovery

Xiao-Ying Yan
Peng-Wei Yin
Xiao-Meng Wu
Jia-Xin Han

Frontiers in Pharmacology

doi 10.3389/fphar.2021.794205

6,951 views
23 citations

Case Report

Published on 05 Nov 2025

A case report of drug–drug interaction between voriconazole and simnotrelvir/ritonavir

in Antibiotics in Clinical Settings

Tingting Chen
Qingquan Zhang

Frontiers in Antibiotics

doi 10.3389/frabi.2025.1705987

1,443 views

Original Research

Published on 27 Sep 2021

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

in Drug Metabolism and Transport

Chen Ning
Shengdi Su
Jiaming Li
Dexuan Kong
Hui Cai
Zhiying Qin
Han Xing
Xijing Chen
Jiake He

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715577

11,062 views
10 citations

Original Research

Published on 18 Jun 2024

Drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics

in Schizophrenia

Cun Zhang
Lei Jiang
Ke Hu
Yi-Jia Zhang
Jing Han
Jin Chen
Bulubu
Boling Dong
Hao-Zhe Shi
Su-Mei He

Frontiers in Psychiatry

doi 10.3389/fpsyt.2024.1377268

4,663 views
4 citations

Original Research

Published on 23 Apr 2021

Integrated Random Negative Sampling and Uncertainty Sampling in Active Learning Improve Clinical Drug Safety Drug–Drug Interaction Information Retrieval

in Predictive Toxicology

Weixin Xie
Limei Wang
Qi Cheng
Xueying Wang
Ying Wang
Hongyuan Bi
Bo He
Weixing Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2020.582470

4,193 views
17 citations

Original Research

Published on 07 May 2021

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

in Translational Pharmacology

Felipe T. Lee-Montiel
Alexander Laemmle
Verena Charwat
Laure Dumont
Caleb S. Lee
Nathaniel Huebsch
Hideaki Okochi
Matthew J. Hancock
Brian Siemons
Steven C. Boggess

Frontiers in Pharmacology

doi 10.3389/fphar.2021.667010

14,374 views
56 citations

Original Research

Published on 30 Apr 2019

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System

in Translational Pharmacology

Annamaria Mascolo
Rosanna Ruggiero
Maurizio Sessa
Cristina Scavone
Liberata Sportiello
Concetta Rafaniello
Francesco Rossi
Annalisa Capuano

Frontiers in Pharmacology

doi 10.3389/fphar.2019.00425

7,566 views
14 citations

Original Research

Published on 02 Apr 2025

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

in Translational Pharmacology

Jazz Q. Stephens
Uriel Blas-Machado
Chrissy Sherrill
David Caudell
Nancy Kock
Ashley M. Davis
Jordyn M. Whitfield
Barry Hart
Kylie Kavanagh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537494

2,072 views

Original Research

Published on 15 Feb 2023

In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542

in Drug Metabolism and Transport

Hyunki Cho
Young Jun Kim
Jung-Woo Chae
Markus R. Meyer
Sang Kyum Kim
Chang Seon Ryu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1067408

3,807 views
8 citations

Original Research

Published on 13 May 2025

Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics

in Psychopharmacology

Cun Zhang
Liang Chen
Yin-Yin Duan
Su-Mei He
Ya-Li Tian
Ying Gao
Dong-Dong Wang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1538996

3,028 views
3 citations

Original Research

Published on 31 Aug 2018

Potential Metabolic Drug–Drug Interaction of Citrus aurantium L. (Rutaceae) Evaluating by Its Effect on 3 CYP450

in Ethnopharmacology

Lu Zhou
Man Cui
Linlin Zhao
Dongsheng Wang
Tao Tang
Wenbo Wang
Sheng Wang
Huiyong Huang
Xinjian Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2018.00895

6,607 views
17 citations

Original Research

Published on 06 Apr 2023

Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

in Drug Metabolism and Transport

Vanessa Zhu
Jürgen Burhenne
Johanna Weiss
Mathias Haag
Ute Hofmann
Matthias Schwab
Stephan Urban
Gerd Mikus
David Czock
Walter E. Haefeli

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1128547

5,638 views
6 citations

Review

Published on 26 Jan 2026

Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects

in Ethnopharmacology

Yan-Xin Li
Han-Zhi Zhong
Shao-Bin Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1755093

884 views

Original Research

Published on 19 Jun 2025

Association of Korean Medicine and polypharmacy with fall risk and mortality in older adults with stroke

in Ethnopharmacology

Ye-Seul Lee
Bo-Hyoung Jang
Jin Pyeong Jeon
Han-Gyul Lee
Seungwon Kwon
Woo-Sang Jung

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621819

3,277 views

Articles

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

Predicting drug–drug interactions between ayahuasca alkaloids and SSRIs using physiologically based pharmacokinetic modeling

Prediction of the Drug–Drug Interaction Types with the Unified Embedding Features from Drug Similarity Networks

A case report of drug–drug interaction between voriconazole and simnotrelvir/ritonavir

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

Drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics

Integrated Random Negative Sampling and Uncertainty Sampling in Active Learning Improve Clinical Drug Safety Drug–Drug Interaction Information Retrieval

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542

Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics

Potential Metabolic Drug–Drug Interaction of Citrus aurantium L. (Rutaceae) Evaluating by Its Effect on 3 CYP450

Evaluation of the drug-drug interaction potential of the novel hepatitis B and D virus entry inhibitor bulevirtide at OATP1B in healthy volunteers

Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects

Association of Korean Medicine and polypharmacy with fall risk and mortality in older adults with stroke