Egfr Amplification | List of Frontiers open access articles

Original Research

Published on 20 Apr 2021

Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma

in Neuro-Oncology and Neurosurgical Oncology

Haiwei Wang
Xinrui Wang
Liangpu Xu
Ji Zhang
Hua Cao

Frontiers in Oncology

doi 10.3389/fonc.2021.551160

9,393 views
25 citations

Original Research

Published on 29 Nov 2021

Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy

in Head and Neck Cancer

Laveniya Satgunaseelan
Sean Porazinski
Dario Strbenac
Aji Istadi
Cali Willet
Tracy Chew
Rosemarie Sadsad
Carsten E. Palme
Jenny H. Lee
Michael Boyer

Frontiers in Oncology

doi 10.3389/fonc.2021.750852

5,937 views
24 citations

Original Research

Published on 01 Aug 2022

EGFR amplification is a putative resistance mechanism for NSCLC–LM patients with TKI therapy and is associated with poor outcome

in Neuro-Oncology and Neurosurgical Oncology

Hainan Yang
Lei Wen
Chao Zhao
Xuefei Li
Changguo Shan
Da Liu
Weiping Hong
Zhaoming Zhou
Cheng Zhou
Linbo Cai

Frontiers in Oncology

doi 10.3389/fonc.2022.902664

8,483 views
11 citations

Case Report

Published on 08 Jun 2021

Case Report: EGFR-Positive Early-Stage Lung Adenocarcinoma Transforming to Squamous Cell Carcinoma After TKI Treatment

in Molecular and Cellular Oncology

Jiatao Liao
Yuan Li
Chang Liu
Qianqian Long
Jialei Wang

Frontiers in Oncology

doi 10.3389/fonc.2021.696881

4,140 views
5 citations

Original Research

Published on 29 Nov 2021

Cinobufagin Is a Selective Anti-Cancer Agent against Tumors with EGFR Amplification and PTEN Deletion

in Pharmacology of Anti-Cancer Drugs

Kunyan He
Guang-Xing Wang
Li-Nan Zhao
Xiao-Fang Cui
Xian-Bin Su
Yi Shi
Tian-Pei Xie
Shang-Wei Hou
Ze-Guang Han

Frontiers in Pharmacology

doi 10.3389/fphar.2021.775602

6,383 views
10 citations

Case Report

Published on 25 Jul 2022

Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18–18 and EGFR amplification: A case report

in Thoracic Oncology

Pascal Wang
Emmanuelle Fabre
Antoine Martin
Kader Chouahnia
Ambre Benabadji
Lise Matton
Boris Duchemann

Frontiers in Oncology

doi 10.3389/fonc.2022.918855

5,202 views
5 citations

Case Report

Published on 11 Aug 2022

Heterogeneity of resistant mechanisms in an EGFR-TKI relapsed patient with EGFR amplification and response to nimotuzumab: A case report

in Molecular and Cellular Oncology

Yan Li
Ziyi Xu
Tongji Xie
Puyuan Xing
Jianming Ying
Junling Li

Frontiers in Oncology

doi 10.3389/fonc.2022.937282

2,819 views
4 citations

Case Report

Published on 25 Mar 2024

Case report: EGFR fusion mutation combined with EGFR amplification responds to EGFR-TKI therapy

in Thoracic Oncology

Zhulin Wang
Chunyao Huang
Wenbo Fan
Shaowu Sun
Kaiyuan Li
Xu Liu
Jiangtao Pu
Guoqing Zhang
Xiangnan Li

Frontiers in Oncology

doi 10.3389/fonc.2024.1347282

3,499 views

Original Research

Published on 26 Feb 2024

Clinical roles of EGFR amplification in diffuse gliomas: a real-world study using the 2021 WHO classification of CNS tumors

in Translational Neuroscience

Hai Wang
Xin Zhang
Jiahui Liu
Wenlin Chen
Xiaopeng Guo
Yaning Wang
Yuekun Wang
Hao Xing
Tingyu Liang
Yixin Shi

Frontiers in Neuroscience

doi 10.3389/fnins.2024.1308627

6,716 views
14 citations

Original Research

Published on 04 Feb 2013

Epidermal Growth Factor Receptor Mutation Status and Rad51 Determine the Response of Glioblastoma to Multimodality Therapy with Cetuximab, Temozolomide, and Radiation

in Radiation Oncology

Phyllis Rachelle Wachsberger
Richard Yaacov Lawrence
Yi Liu
Barbara Rice
Constantine Daskalakis
Adam P Dicker

Frontiers in Oncology

doi 10.3389/fonc.2013.00013

7,100 views
12 citations

Case Report

Published on 06 Apr 2022

Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports

in Pharmacology of Anti-Cancer Drugs

Yue Zeng
Yuanqing Feng
Guihua Fu
Junlan Jiang
Xiaohan Liu
Yue Pan
Chunhong Hu
Xianling Liu
Fang Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.838247

4,262 views
6 citations

Original Research

Published on 28 May 2024

Prognostic significance of EGFR, AREG and EREG amplification and gene expression in muscle invasive bladder cancer

in Genitourinary Oncology

Daniel Uysal
Blerta Thaqi
Alexander Fierek
David Jurgowski
Zoran V. Popovic
Fabian Siegel
Maurice Stephan Michel
Philipp Nuhn
Thomas Stefan Worst
Philipp Erben

Frontiers in Oncology

doi 10.3389/fonc.2024.1370303

3,433 views
2 citations

Brief Research Report

Published on 06 Aug 2025

Genomic trajectories of colorectal cancer with choroidal metastasis: longitudinal insights from tissue and liquid biopsy via next-generation sequencing

in Cancer Genetics and Oncogenomics

Alessandro Ottaiano
Luisa Circelli
Carmine Picone
Monica Ianniello
Raffaella Ruggiero
Roberto Sirica
Mariachiara Santorsola
Anna Chiara Carratù
Nadia Petrillo
Gaetana Cerbone

Frontiers in Genetics

doi 10.3389/fgene.2025.1632580

2,597 views

Original Research

Published on 10 Sep 2021

High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

in Cancer Immunity and Immunotherapy

Radhika Thokala
Zev A. Binder
Yibo Yin
Logan Zhang
Jiasi Vicky Zhang
Daniel Y. Zhang
Michael C. Milone
Guo-li Ming
Hongjun Song
Donald M. O’Rourke

Frontiers in Oncology

doi 10.3389/fonc.2021.664236

9,475 views
34 citations

Original Research

Published on 18 May 2023

Heterogeneity in clinical prognosis, immune infiltration and molecular characteristics of three glycolytic subtypes in lower-grade gliomas

in Cancer Metabolism

Shenglian Wu
Lulu Sheng
Shucai Fan
Xi Guo
Biao Zhu
Cheng Wu
Bing Lei

Frontiers in Oncology

doi 10.3389/fonc.2023.1180662

2,854 views
1 citation

Hypothesis and Theory

Published on 04 Oct 2018

Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population

in Radiation Oncology

Xavier Muracciole
Wassim El-amine
Emmeline Tabouret
Mohamed Boucekine
Anne Barlier
Gregorio Petrirena
Tovo Harivony
Laetitia Solignac
Olivier L. Chinot
Nicolas Macagno

Frontiers in Oncology

doi 10.3389/fonc.2018.00426

3,785 views
12 citations

Articles

Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With Glioma

Oral Squamous Cell Carcinoma in Young Patients Show Higher Rates of EGFR Amplification: Implications for Novel Personalized Therapy

EGFR amplification is a putative resistance mechanism for NSCLC–LM patients with TKI therapy and is associated with poor outcome

Case Report: EGFR-Positive Early-Stage Lung Adenocarcinoma Transforming to Squamous Cell Carcinoma After TKI Treatment

Cinobufagin Is a Selective Anti-Cancer Agent against Tumors with EGFR Amplification and PTEN Deletion

Successful sequential tyrosine kinase inhibitors to overcome a rare compound of EGFR exon 18–18 and EGFR amplification: A case report

Heterogeneity of resistant mechanisms in an EGFR-TKI relapsed patient with EGFR amplification and response to nimotuzumab: A case report

Case report: EGFR fusion mutation combined with EGFR amplification responds to EGFR-TKI therapy

Clinical roles of EGFR amplification in diffuse gliomas: a real-world study using the 2021 WHO classification of CNS tumors

Epidermal Growth Factor Receptor Mutation Status and Rad51 Determine the Response of Glioblastoma to Multimodality Therapy with Cetuximab, Temozolomide, and Radiation

Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports

Prognostic significance of EGFR, AREG and EREG amplification and gene expression in muscle invasive bladder cancer

Genomic trajectories of colorectal cancer with choroidal metastasis: longitudinal insights from tissue and liquid biopsy via next-generation sequencing

High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Heterogeneity in clinical prognosis, immune infiltration and molecular characteristics of three glycolytic subtypes in lower-grade gliomas

Negative Survival Impact of High Radiation Doses to Neural Stem Cells Niches in an IDH-Wild-Type Glioblastoma Population