Endogenous Metabolites | List of Frontiers open access articles

Original Research

Published on 08 Mar 2021

Studies on the Changes of Pharmacokinetics Behaviors of Phytochemicals and the Influence on Endogenous Metabolites After the Combination of Radix Bupleuri and Radix Paeoniae Alba Based on Multi-Component Pharmacokinetics and Metabolomics

in Ethnopharmacology

Congcong Chen
Qicai Yin
Junshen Tian
Xiaoxia Gao
Xuemei Qin
Guanhua Du
Yuzhi Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2021.630970

7,548 views
18 citations

Original Research

Published on 12 May 2021

Global-Scale Metabolomic Profiling of Human Hair for Simultaneous Monitoring of Endogenous Metabolome, Short- and Long-Term Exposome

in Analytical Chemistry

Ying Chen
Jian Guo
Shipei Xing
Huaxu Yu
Tao Huan

Frontiers in Chemistry

doi 10.3389/fchem.2021.674265

8,152 views
25 citations

Original Research

Published on 12 Dec 2011

Activation of Astroglial Calcium Signaling by Endogenous Metabolites Succinate and Gamma-Hydroxybutyrate in the Nucleus Accumbens

Tünde Molnár
László Héja
Zsuzsa Emri
Ágnes Simon
Gabriella Nyitrai
Ildikó Pál
Julianna Kardos

Frontiers in Neuroenergetics

doi 10.3389/fnene.2011.00007

7,689 views
11 citations

Original Research

Published on 17 May 2017

Metabolic Profiling Analysis of the Alleviation Effect of Treatment with Baicalin on Cinnabar Induced Toxicity in Rats Urine and Serum

in Ethnopharmacology

Guangyue Su
Gang Chen
Xiao An
Haifeng Wang
Yue-Hu Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2017.00271

5,099 views
18 citations

Original Research

Published on 11 Sep 2018

Protective Effects of Total Glycoside From Rehmannia glutinosa Leaves on Diabetic Nephropathy Rats via Regulating the Metabolic Profiling and Modulating the TGF-β1 and Wnt/β-Catenin Signaling Pathway

in Ethnopharmacology

Xinxin Dai
Shulan Su
Hongdie Cai
Dandan Wei
Hui Yan
Tianyao Zheng
Zhenhua Zhu
Er-xin Shang
Sheng Guo
Dawei Qian

Frontiers in Pharmacology

doi 10.3389/fphar.2018.01012

7,662 views
35 citations

Original Research

Published on 02 Feb 2015

Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux

in Cellular Neurophysiology

Marcio H. M. da Luz
Italo T. Peres
Tiago G. Santos
Vilma R. Martins
Marcelo Y. Icimoto
Kil S. Lee

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2015.00012

8,427 views
20 citations

Original Research

Published on 19 Jul 2022

A UPLC-Q-TOF-MS-Based Metabolomics Approach to Screen out Active Components in Prepared Rhubarb for Its Activity on Noxious Heat Blood Stasis Syndrome

in Ethnopharmacology

Hui Zhu
Yu Duan
Kunming Qin
Junjie Jin
Xiao Liu
Baochang Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2022.907831

4,257 views
8 citations

Original Research

Published on 27 Sep 2018

Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress

in Mood Disorders

Jianguo Li
Luwen Hou
Cui Wang
Xueyang Jia
Xuemei Qin
Changxin Wu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2018.00454

7,877 views
58 citations

Review

Published on 23 Nov 2020

The Chemical Exposome of Human Aging

in Genetics of Aging

Biswapriya B. Misra

Frontiers in Genetics

doi 10.3389/fgene.2020.574936

22,063 views
42 citations

Original Research

Published on 28 Jun 2022

Study on the Antipyretic and Anti-inflammatory Mechanism of Shuanghuanglian Oral Liquid Based on Gut Microbiota-Host Metabolism

in Ethnopharmacology

Yan Gao
Lu Liu
Chen Li
Yu-Ting Liang
Jing Lv
Long-Fei Yang
Bo-Nian Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2022.843877

6,600 views
16 citations

Editorial

Published on 08 Nov 2023

Editorial: The cross-talk between gut microbiota and endogenous metabolites in endocrine diseases, volume II

in Gut Endocrinology

Van B. Lu
Guilherme Zweig Rocha

Frontiers in Endocrinology

doi 10.3389/fendo.2023.1320646

1,536 views

Original Research

Published on 13 Nov 2024

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

in Experimental Pharmacology and Drug Discovery

Juan Chen
Szetuen Ng
Pengchao Xu
Sainan Chen
Shengqiang Li
Xuan Chen
Lihua Xie
Jirong Ge

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505231

2,861 views
1 citation

Original Research

Published on 12 Nov 2021

Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

in Drug Metabolism and Transport

Anne Michelli Reis Silveira
Gustavo Henrique Bueno Duarte
Anna Maria Alves de Piloto Fernandes
Pedro Henrique Dias Garcia
Nelson Rogerio Vieira
Marcia Aparecida Antonio
Patricia de Oliveira Carvalho

Frontiers in Pharmacology

doi 10.3389/fphar.2021.752960

7,536 views
8 citations

Original Research

Published on 05 Aug 2021

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

in Ethnopharmacology

Zhimin Miao
Yong Lai
Yingying Zhao
Lingmin Chen
Jianeng Zhou
Chunyan Li
Yan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.710692

5,655 views
26 citations

Original Research

Published on 16 Apr 2025

Metabolomic analysis of fatal hypothermia using ultra-high-performance liquid chromatography‒mass spectrometry

in Metabolomics

Jia-Hao Li
Jia-Li Liu
Jian-Wen Song
Wei-Liang Deng
Xin-Zhi Cao
Zhong-Wen Wu
Ding-Hao Chen
Hui Wang
Song Yu
Qi Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1563642

2,356 views
1 citation

Original Research

Published on 25 Oct 2021

Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule

in Ethnopharmacology

Jun-sheng Tian
Hui-liang Zhao
Yao Gao
Qi Wang
Huan Xiang
Xiang-ping Xu
Sheng Huang
Dong-lan Yan
Xue-mei Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.657047

5,275 views
11 citations

Articles

Studies on the Changes of Pharmacokinetics Behaviors of Phytochemicals and the Influence on Endogenous Metabolites After the Combination of Radix Bupleuri and Radix Paeoniae Alba Based on Multi-Component Pharmacokinetics and Metabolomics

Global-Scale Metabolomic Profiling of Human Hair for Simultaneous Monitoring of Endogenous Metabolome, Short- and Long-Term Exposome

Activation of Astroglial Calcium Signaling by Endogenous Metabolites Succinate and Gamma-Hydroxybutyrate in the Nucleus Accumbens

Metabolic Profiling Analysis of the Alleviation Effect of Treatment with Baicalin on Cinnabar Induced Toxicity in Rats Urine and Serum

Protective Effects of Total Glycoside From Rehmannia glutinosa Leaves on Diabetic Nephropathy Rats via Regulating the Metabolic Profiling and Modulating the TGF-β1 and Wnt/β-Catenin Signaling Pathway

Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux

A UPLC-Q-TOF-MS-Based Metabolomics Approach to Screen out Active Components in Prepared Rhubarb for Its Activity on Noxious Heat Blood Stasis Syndrome

Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress

The Chemical Exposome of Human Aging

Study on the Antipyretic and Anti-inflammatory Mechanism of Shuanghuanglian Oral Liquid Based on Gut Microbiota-Host Metabolism

Editorial: The cross-talk between gut microbiota and endogenous metabolites in endocrine diseases, volume II

Herbal formula xuling-jiangu improves bone metabolic balance in rats with ovariectomy-induced osteoporosis via the gut-bone axis

Serum Predose Metabolic Profiling for Prediction of Rosuvastatin Pharmacokinetic Parameters in Healthy Volunteers

Protective Property of Scutellarin Against Liver Injury Induced by Carbon Tetrachloride in Mice

Metabolomic analysis of fatal hypothermia using ultra-high-performance liquid chromatography‒mass spectrometry

Branched-Chain Amino Acids Catabolism Pathway Regulation Plays a Critical Role in the Improvement of Leukopenia Induced by Cyclophosphamide in 4T1 Tumor-Bearing Mice Treated With Lvjiaobuxue Granule