Erk12 Signaling | List of Frontiers open access articles

Original Research

Published on 18 Mar 2021

TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway

in Molecular and Cellular Oncology

Jianyou Gu
Wenjie Huang
Junfeng Zhang
Xianxing Wang
Tian Tao
Ludi Yang
Yao Zheng
Songsong Liu
Jiali Yang
Liwei Zhu

Frontiers in Oncology

doi 10.3389/fonc.2021.628353

5,978 views
20 citations

Review

Published on 09 May 2025

The role of ERK1/2 signaling in diabetes: pathogenic and therapeutic implications

in Experimental Pharmacology and Drug Discovery

Hanlin Xu
Tao Liu
Yanfen Dai
Na Li
Zhanqi Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600251

4,454 views
7 citations

Original Research

Published on 12 Jul 2022

GPR12 Inhibits Apoptosis in Epithelial Ovarian Cancer via the Activation of ERK1/2 Signaling

in Gynecological Oncology

Lu Wang
Da Yang
Yao Zhang
Yisheng Jiao

Frontiers in Oncology

doi 10.3389/fonc.2022.932689

2,566 views
4 citations

Original Research

Published on 03 Feb 2026

Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial–mesenchymal transition

in Experimental Pharmacology and Drug Discovery

Lingdan Wu
Meiling Chen
Jinghua Chai
Yujie Tang
Qihua Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1634617

428 views

Original Research

Published on 31 Jan 2020

BAG2 Promotes Proliferation and Metastasis of Gastric Cancer via ERK1/2 Signaling and Partially Regulated by miR186

in Molecular and Cellular Oncology

Lisha Sun
Guanglei Chen
Anqi Sun
Zheng Wang
Haibo Huang
Ziming Gao
Weitian Liang
Caigang Liu
Kai Li

Frontiers in Oncology

doi 10.3389/fonc.2020.00031

7,694 views
34 citations

Review

Published on 14 Aug 2019

Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury

in Integrative Physiology

Tingting Kong
Minghui Liu
Bingyuan Ji
Bo Bai
Baohua Cheng
Chunmei Wang

Frontiers in Physiology

doi 10.3389/fphys.2019.01038

37,194 views
109 citations

Original Research

Published on 08 Jul 2021

PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway

in Molecular and Cellular Oncology

Banban Li
Ruinan Jia
Wei Li
Ying Zhou
Dongmei Guo
Qingliang Teng
Shenghong Du
Mingying Li
Wěi Li
Tao Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.686695

5,410 views
13 citations

Original Research

Published on 18 Mar 2022

Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1/2 Signaling Pathway

in Respiratory Pharmacology

Linqian Peng
Yunwei Chen
Yan Li
Panpan Feng
Yan Zheng
Yongjie Dong
Yunjing Yang
Ruiyu Wang
Ailing Li
Jianghong Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2022.767705

4,801 views
18 citations

Original Research

Published on 23 Jun 2022

MicroRNA-574 Impacts Granulosa Cell Estradiol Production via Targeting TIMP3 and ERK1/2 Signaling Pathway

in Experimental Endocrinology

Bo Pan
Xiaoshu Zhan
Julang Li

Frontiers in Endocrinology

doi 10.3389/fendo.2022.852127

3,898 views
16 citations

Original Research

Published on 23 Jan 2023

Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking

in Pharmacology of Anti-Cancer Drugs

Yu Hu
Wenjuan Zhai
Duanling Tan
Haipeng Chen
Guiyu Zhang
Xuanjing Tan
Yuting Zheng
Wenhui Gao
Yijie Wei
Jinjun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1111912

5,711 views
19 citations

Original Research

Published on 02 Feb 2023

Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids

in Molecular Signalling and Pathways

Facundo Ferrero Restelli
Fernando Federicci
Fernanda Ledda
Gustavo Paratcha

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1090824

2,929 views
3 citations

Original Research

Published on 12 Oct 2017

KCa3.1 Inhibition Switches the Astrocyte Phenotype during Astrogliosis Associated with Ischemic Stroke Via Endoplasmic Reticulum Stress and MAPK Signaling Pathways

in Cellular Neuropathology

Zhihua Yu
Mengni Yi
Tianjiao Wei
Xiaoling Gao
Hongzhuan Chen

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2017.00319

5,294 views
23 citations

Original Research

Published on 11 Jan 2021

Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function

in Cardiovascular and Smooth Muscle Pharmacology

Jinjun Wu
Muyan Kong
Yanmei Lou
Leyan Li
Chunlin Yang
Huifang Xu
Yuqi Cui
Hong Hao
Zhenguo Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2020.608518

5,908 views
22 citations

Original Research

Published on 23 Oct 2020

β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells

in Animal Reproduction - Theriogenology

Ximena Valderrama
Cesar Ulloa-Leal
Mauricio Erciario Silva
Jose Goicochea
Silvana Apichela
Martin Argañaraz
Luciana Sari
Luis Paiva
Vicente Francisco Ratto
Marcelo Hector Ratto

Frontiers in Veterinary Science

doi 10.3389/fvets.2020.586265

4,311 views
10 citations

Original Research

Published on 24 Sep 2021

Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling Pathways

in Bone Research

Mengbo Zhu
Wenbin Xu
Jiuzhou Jiang
Yining Wang
Yanjing Guo
Ruijia Yang
Yaqiong Chang
Bin Zhao
Zhenyu Wang
Jianfeng Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2021.736863

5,259 views
19 citations

Mini Review

Published on 05 Oct 2018

ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory

in Neuroplasticity and Development

Jorge H. Medina
Haydee Viola

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2018.00361

10,359 views
70 citations

Articles

TMPRSS4 Promotes Cell Proliferation and Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma by Activating ERK1/2 Signaling Pathway

The role of ERK1/2 signaling in diabetes: pathogenic and therapeutic implications

GPR12 Inhibits Apoptosis in Epithelial Ovarian Cancer via the Activation of ERK1/2 Signaling

Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial–mesenchymal transition

BAG2 Promotes Proliferation and Metastasis of Gastric Cancer via ERK1/2 Signaling and Partially Regulated by miR186

Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury

PAK1 Mediates Bone Marrow Stromal Cell-Induced Drug Resistance in Acute Myeloid Leukemia via ERK1/2 Signaling Pathway

Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1/2 Signaling Pathway

MicroRNA-574 Impacts Granulosa Cell Estradiol Production via Targeting TIMP3 and ERK1/2 Signaling Pathway

Uncovering the effects and molecular mechanism of Astragalus membranaceus (Fisch.) Bunge and its bioactive ingredients formononetin and calycosin against colon cancer: An integrated approach based on network pharmacology analysis coupled with experimental validation and molecular docking

Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids

KCa3.1 Inhibition Switches the Astrocyte Phenotype during Astrogliosis Associated with Ischemic Stroke Via Endoplasmic Reticulum Stress and MAPK Signaling Pathways

Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function

β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells

Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling Pathways

ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory