Exhausted T Cells | List of Frontiers open access articles

Original Research

Published on 07 Mar 2023

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Yueting Huang
Huijian Zheng
Yuwen Zhu
Yan Hong
Jie Zha
Zhijuan Lin
Zhifeng Li
Caiyan Wang
Zhihong Fang
Xingxing Yu

Frontiers in Immunology

doi 10.3389/fimmu.2023.1139517

8,359 views
29 citations

Review

Published on 14 Apr 2023

Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities

in T Cell Biology

Anna E. Brunell
Riitta Lahesmaa
Anu Autio
Anil K. Thotakura

Frontiers in Immunology

doi 10.3389/fimmu.2023.1151632

21,982 views
34 citations

Original Research

Published on 25 Feb 2026

Reversing T cell dysfunction in a novel in vitro model of T cell exhaustion reveals differential roles of RASA2

in Cancer Immunity and Immunotherapy

Hilal Saraç
Rachael Nicholson
Rebecca N. Graham
Meera Augustus
Raha Taghavi
Dympna J. Connolly
Lindsay Lim
Sofia Lourenco

Frontiers in Immunology

doi 10.3389/fimmu.2026.1509926

836 views

Original Research

Published on 31 Jan 2023

Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies

in Cancer Immunity and Immunotherapy

Shanshan Wan
Ende Zhao
Daniel Freeman
Daniel Weissinger
Benjamin A. Krantz
Gregor Werba
Lauren G. Khanna
Despina Siolas
Paul E. Oberstein
Pratip K. Chattopadhyay

Frontiers in Immunology

doi 10.3389/fimmu.2023.1067352

5,131 views
4 citations

Original Research

Published on 14 Jun 2022

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells

in Viral Immunology

Karla M. Viramontes
Emily N. Neubert
Julia M. DeRogatis
Roberto Tinoco

Frontiers in Immunology

doi 10.3389/fimmu.2022.869768

10,890 views
20 citations

Original Research

Published on 30 May 2025

Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers

in Cancer Immunity and Immunotherapy

Ji-Ae Lee
Hye Eun Park
Dae-Won Lee
Sae-Won Han
Tae-You Kim
Seung-Yong Jeong
Kyu Joo Park
Jeong Mo Bae
Gyeong Hoon Kang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601188

3,439 views
4 citations

Original Research

Published on 09 Jul 2021

T-Cell Exhaustion Status Under High and Low Levels of Hypoxia-Inducible Factor 1α Expression in Glioma

in Inflammation Pharmacology

Shuai Liu
Xing Liu
Chuanbao Zhang
Wei Shan
Xiaoguang Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.711772

7,192 views
28 citations

Original Research

Published on 07 Feb 2020

Association Between Response to Nivolumab Treatment and Peripheral Blood Lymphocyte Subsets in Patients With Non-small Cell Lung Cancer

in Cancer Immunity and Immunotherapy

Selene Ottonello
Carlo Genova
Irene Cossu
Vincenzo Fontana
Erika Rijavec
Giovanni Rossi
Federica Biello
Maria Giovanna Dal Bello
Marco Tagliamento
Angela Alama

Frontiers in Immunology

doi 10.3389/fimmu.2020.00125

11,725 views
82 citations

Mini Review

Published on 18 May 2023

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer

in Molecular Innate Immunity

Junfeng Zhang
Feifei Lei
Huabing Tan

Frontiers in Immunology

doi 10.3389/fimmu.2023.1166128

16,924 views
25 citations

Original Research

Published on 09 Aug 2021

p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells

in Cancer Immunity and Immunotherapy

Valérie Janelle
Mathieu Neault
Marie-Ève Lebel
Dave Maurice De Sousa
Salix Boulet
Ludovic Durrieu
Cédric Carli
Chloé Muzac
Sébastien Lemieux
Nathalie Labrecque

Frontiers in Immunology

doi 10.3389/fimmu.2021.698565

14,041 views
49 citations

Original Research

Published on 16 Jun 2020

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

in Cancer Immunity and Immunotherapy

Wen Juan Tu
Robert D. McCuaig
Abel H. Y. Tan
Kristine Hardy
Nabila Seddiki
Sayed Ali
Jane E. Dahlstrom
Elaine G. Bean
Jenny Dunn
Jade Forwood

Frontiers in Immunology

doi 10.3389/fimmu.2020.01228

13,388 views
56 citations

Original Research

Published on 20 Dec 2022

Evidence of exhausted lymphocytes after the third anti-SARS-CoV-2 vaccine dose in cancer patients

in Cancer Immunity and Immunotherapy

Javier David Benitez Fuentes
Kauzar Mohamed Mohamed
Alicia de Luna Aguilar
Carlos Jiménez García
Kissy Guevara-Hoyer
Miguel Fernandez-Arquero
M Antonia Rodríguez de la Peña
Laura Garciía Bravo
Alejandro Francisco Jiménez Ortega
Paloma Flores Navarro

Frontiers in Oncology

doi 10.3389/fonc.2022.975980

19,342 views
29 citations

Review

Published on 07 Feb 2024

Modern cancer therapy: cryoablation meets immune checkpoint blockade

in Cancer Immunity and Immunotherapy

Qi Liu
Chunyang Zhang
Xuxin Chen
Zhihai Han

Frontiers in Oncology

doi 10.3389/fonc.2024.1323070

6,252 views
16 citations

Original Research

Published on 24 Jan 2025

Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors

in Cancer Immunity and Immunotherapy

Gulfiya Kadyrzhanova
Miho Tamai
Shukla Sarkar
Rajkumar Singh Kalra
Hiroki Ishikawa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1484303

6,183 views
4 citations

Original Research

Published on 08 Dec 2021

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma

in Molecular and Cellular Pathology

Wenhao Xu
Wenkai Zhu
Xi Tian
Wangrui Liu
Yuanyuan Wu
Aihetaimujiang Anwaier
Jiaqi Su
Shiyin Wei
Yuanyuan Qu
Hailiang Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2021.772436

4,811 views
8 citations

Original Research

Published on 09 Aug 2021

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer

in T Cell Biology

Jiaqi Hu
Chongyin Han
Jiayuan Zhong
Huisheng Liu
Rui Liu
Wei Luo
Pei Chen
Fei Ling

Frontiers in Immunology

doi 10.3389/fimmu.2021.691142

15,173 views
39 citations

Articles

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities

Reversing T cell dysfunction in a novel in vitro model of T cell exhaustion reveals differential roles of RASA2

Tumor infiltrating T cell states and checkpoint inhibitor expression in hepatic and pancreatic malignancies

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells

Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers

T-Cell Exhaustion Status Under High and Low Levels of Hypoxia-Inducible Factor 1α Expression in Glioma

Association Between Response to Nivolumab Treatment and Peripheral Blood Lymphocyte Subsets in Patients With Non-small Cell Lung Cancer

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer

p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Evidence of exhausted lymphocytes after the third anti-SARS-CoV-2 vaccine dose in cancer patients

Modern cancer therapy: cryoablation meets immune checkpoint blockade

Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma

Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed to T Cell Exhaustion in Colorectal Cancer