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4 articles related to "Factor Xia"

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Articles

Original Research

Published on 19 Mar 2021

Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant

in Atherosclerosis and Vascular Medicine

Mostafa Hamada
Varsha Bhakta
Sara N. Andres
William P. Sheffield

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2021.647405

4,111 views
5 citations

Original Research

Published on 22 Jun 2023

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

in Molecular Innate Immunity

Myriam Martin
Sara C. Nilsson
David Eikrem
Karin Fromell
Carsten Scavenius
Leonie M. Vogt
Ewa Bielecka
Jan Potempa
Jan J. Enghild
Bo Nilsson

Frontiers in Immunology

doi 10.3389/fimmu.2023.1203506

10,008 views
6 citations

Clinical Trial

Published on 10 Feb 2022

First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects

in Translational Pharmacology

Rui Chen
Xiaoduo Guan
Pei Hu
Yanli Dong
Yi Zhu
Tengfei Zhang
Jianjun Zou
Shuyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.821363

6,324 views
21 citations

Original Research

Published on 19 Oct 2022

SHR2285, the first selectively oral FXIa inhibitor in China: Safety, tolerability, pharmacokinetics and pharmacodynamics combined with aspirin, clopidogrel or ticagrelor

in Drug Metabolism and Transport

Tingting Ma
Yanli Dong
Lei Huang
Yuanxun Yang
Yan Geng
Fei Fei
Pinhao Xie
Yu Zhao
Hui Lin
Zeyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1027627

5,313 views
12 citations