Forced Degradation | List of Frontiers open access articles

Original Research

Published on 04 May 2016

Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities

in Predictive Toxicology

Piotr Pikul
Marzena Jamrógiewicz
Joanna Nowakowska
Weronika Hewelt-Belka
Krzesimir Ciura

Frontiers in Pharmacology

doi 10.3389/fphar.2016.00117

11,508 views
13 citations

Original Research

Published on 11 Apr 2022

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

in Structural Biology

John P. Giddens
John E. Schiel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2022.789973

3,128 views
3 citations

Original Research

Published on 14 Feb 2022

Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS

in Medicinal and Pharmaceutical Chemistry

Xiaosha Tao
Ye Tian
Wan-Hui Liu
Shangchen Yao
Lihui Yin

Frontiers in Chemistry

doi 10.3389/fchem.2022.834124

8,141 views
17 citations

Original Research

Published on 01 Dec 2025

A novel reversed phase high performance liquid chromatography approach for stability-indicating simultaneous analysis of brimonidine tartrate and timolol maleate

in Medicinal and Pharmaceutical Chemistry

Aktham Mestareehi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1678541

2,444 views

Original Research

Published on 22 Sep 2025

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

in Medicinal and Pharmaceutical Chemistry

Ronghua Ni
Jisu Qin
Wenyi Wu
Jinqiu Xu
Qunfeng Luo
Liangliang Cai

Frontiers in Chemistry

doi 10.3389/fchem.2025.1659507

3,756 views

Original Research

Published on 25 Apr 2025

Comprehensive and robust stability-indicating reversed phase high performance liquid chromatography (RP-HPLC) method for Rivaroxaban: synergistic integration of infrared spectroscopy and clinical pharmacology insights

in Analytical Chemistry

Aktham Mestareehi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1551189

4,586 views
5 citations

Articles

Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

Trace Level Quantification of 4-Methyl-1-nitrosopiperazin in Rifampicin Capsules by LC-MS/MS

A novel reversed phase high performance liquid chromatography approach for stability-indicating simultaneous analysis of brimonidine tartrate and timolol maleate

Reversed phase HPLC analysis of mobocertinib and its impurities and studies on the structure and biological activity of a new degradation product

Comprehensive and robust stability-indicating reversed phase high performance liquid chromatography (RP-HPLC) method for Rivaroxaban: synergistic integration of infrared spectroscopy and clinical pharmacology insights